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Research: Formulation of quinine suppository for initiation of early treatment of malaria – a preliminary study

December 10, 2012 - 10:04 -- Bart G.J. Knols
Rebecca O. Soremekun, Boladale O. Silva, Fola Tayo, Cecilia I. Igwilo
MWJ 2012, 3, 14

The aim of this study was to develop a quinine suppository with adequate release properties that also meets the dual conditions of affordability and ease of administration. Cocoa butter and FattibaseTM were used in the preparation of suppositories containing 200 mg quinine bisulphate. Release profiles of formulations with varying concentrations of polysorbate 80 (0 – 5%) were evaluated by in vitro dissolution in pH 8 buffer medium. Formulations with the two bases released quinine in adequate quantities for the management of malaria.

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