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Factors associated with malaria vaccine uptake in Sunyani Municipality, Ghana

July 28, 2021 - 15:08 -- Open Access
Dennis Tabiri, Jean Claude Romaric Pingdwindé Ouédraogo and Priscilla Awo Nortey
Malaria Journal 2021 20:325, 27 July 2021

Malaria continues to be a major disease of public health concern affecting several million people worldwide. The World Health Organization (WHO) started a pilot study on a malaria vaccine (RTS,S) in Ghana and two other countries in 2019. This study aimed at assessing the factors associated with uptake of the vaccine in the Sunyani Municipality of Ghana.

Associations Between Malaria in Pregnancy and Neonatal Neurological Outcomes: Malaria in Pregnancy and Neonatal Neurological Outcomes

July 21, 2021 - 18:08 -- Open Access
Lawford HLS, Nuamah MA, Bora S, et al.
Int J Infect Dis. 2021 Jul 17:S1201-9712(21)00593-2

To compare neurological functioning of neonates born to mothers with and without malaria in pregnancy.

Impact of IgG response to malaria-specific antigens and immunity against malaria in pre-school children in Ghana. A cluster randomized, placebo-controlled trial

July 21, 2021 - 18:06 -- Open Access
Tchum SK, Sakyi SA, Adu B, Arthur F, Oppong FB, Dzabeng F, Amoani B, Gyan T, Poku-Asante K
PLoS One. 2021 Jul 20;16(7):e0253544

Iron fortification and micronutrient initiatives, specifically, vitamin A, and zinc supplementation are the most cost-effective developmental strategies against malnutrition and health emergencies in pre-school children. Iron-deficiency among pre-school children have been documented, however, studies evaluating the impact of immunoglobulin G (IgG) isotype responses among iron-fortified pre-school children in malaria endemic communities has not been assessed. We evaluated the impact of iron fortification on the IgG responses to GLURP R0, GLURP R2 and MSP3 FVO malaria-specific antigens among pre-school children in malaria endemic areas.

Emerging properties of malaria transmission and persistence in urban Accra, Ghana: evidence from a participatory system approach

July 21, 2021 - 17:58 -- Open Access
Merveille Koissi Savi, Daniel Callo-Concha, Henri E. Z. Tonnang and Christian Borgemeister
Malaria Journal 2021 20:321, 19 July 2021

Several studies that aim to enhance the understanding of malaria transmission and persistence in urban settings failed to address its underlining complexity. This study aims at doing that by applying qualitative and participatory-based system analysis and mapping to elicit the system’s emergent properties.

Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study

July 13, 2021 - 14:42 -- Open Access
Thye T, Evans JA, Ruge G, Loag W, Ansong D, Agbenyega T, Horstmann RD, May J, Schuldt K
J Hum Genet. 2021 Jul 7

Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 children from the Ashanti Region in Ghana, West Africa.

Not Open Access | The impact of indoor residual spraying on Plasmodium falciparum microsatellite variation in an area of high seasonal malaria transmission in Ghana, West Africa

June 22, 2021 - 14:44 -- NOT Open Access
Argyropoulos DC, Ruybal-Pesántez S, Deed SL, Oduro AR, Dadzie SK, Appawu MA, Asoala V, Pascual M, Koram KA, Day KP, Tiedje KE
Mol Ecol. 2021 Jun 18

Here we report the first population genetic study to examine the impact of indoor residual spraying (IRS) on Plasmodium falciparum in humans. This study was conducted in an area of high seasonal malaria transmission in Bongo District, Ghana. IRS was implemented during the dry season (November - May) in three consecutive years between 2013 and 2015 to reduce transmission and attempt to bottleneck the parasite population in humans towards lower diversity with greater linkage disequilibrium. The study was done against a background of widespread use of long-lasting insecticidal nets, typical for contemporary malaria control in West Africa.

NOT Open Access | Plasmodium falciparum Pf77 and male development gene 1 as vaccine antigens that induce potent transmission-reducing antibodies

June 16, 2021 - 14:59 -- NOT Open Access
Tripathi AK, Oakley MS, Kumar S, et al.
Sci Transl Med. 2021 Jun 9;13(597):eabg2112

Malaria vaccines that disrupt the Plasmodium life cycle in mosquitoes and reduce parasite transmission in endemic areas are termed transmission-blocking vaccines (TBVs). Despite decades of research, there are only a few Plasmodium falciparum antigens that indisputably and reproducibly demonstrate transmission-blocking immunity. So far, only two TBV candidates have advanced to phase 1/2 clinical testing with limited success.

Impact of malaria diagnostic refresher training programme on competencies and skills in malaria diagnosis among medical laboratory professionals: evidence from Ghana 2015–2019

June 9, 2021 - 07:50 -- Open Access
Mary Tetteh, Duah Dwomoh, Alexander Asamoah, Edward King Kupeh, Keziah Malm and Justice Nonvignon
Malaria Journal 2021 20:255, 8 June 2021

The quality of malaria test results is crucial for optimal patient treatment and care. The Ghana Health Service is successfully shifting from presumptive clinical diagnosis and treatment of malaria to the Test, Treat and Track (T3) initiative. In line with the initiative, the National Malaria Control Programme (NMCP) set out to improve the capacity of medical laboratory professionals in Ghana through a five-day Malaria Diagnostic Refresher Training (MDRT) to build competencies and skills in malaria diagnosis, especially in the three components of microscopy: parasite detection, species identification and parasite quantification. This study evaluates the impact of the training on malaria microscopy.

Determinants of the varied profiles of Plasmodium falciparum infections among infants living in Kintampo, Ghana

June 5, 2021 - 06:18 -- Open Access
Akua Kyerewaa Botwe, Felix Boakye Oppong, Stephaney Gyaase, Seth Owusu-Agyei, Muhammad Asghar, Kwaku Poku Asante, Anna Färnert and Faith Osier
Malaria Journal 2021 20:240, 29 May 2021

Understanding why some infants tolerate infections, remaining asymptomatic while others succumb to repeated symptomatic malaria is beneficial for studies of naturally acquired immunity and can guide control interventions. This study compared demographic, host and maternal factors associated with being either parasite negative or having asymptomatic infections versus developing symptomatic malaria in the first year of life.

Predictors of placental malaria in Upper West Regional Hospital-Ghana

June 1, 2021 - 12:57 -- Open Access
Mwin PK, Kuffuor A, Nuhu K, Okine R, Kubio C, Wurapa F, Osei FA, Afari E
BMC Pregnancy Childbirth. 2021 May 26;21(1):403

Placental malaria (PM) poses life-threatening complications to pregnant women as they are at increased risk of maternal and perinatal morbidity and mortality associated with malaria. This study examined the factors associated with placental malaria in the Upper West Regional Hospital (UWR).



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