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Intermittent preventive treatment comparing two versus three doses of sulphadoxine pyrimethamine (IPTp-SP) in the prevention of anaemia in pregnancy in Ghana: A cross-sectional study

April 22, 2021 - 08:21 -- Open Access
Agyeman YN, Newton S, Annor RB, Owusu-Dabo E
PLoS One. 2021 Apr 20;16(4):e0250350

In 2012 the World Health Organisation (WHO) revised the policy on Intermittent Preventive Treatment with Sulphadoxine Pyrimethamine (IPTp-SP) to at least three doses for improved protection against malaria parasitaemia and its associated effects such as anaemia during pregnancy. We assessed the different SP dosage regimen available under the new policy to determine the dose at which women obtained optimal protection against anaemia during pregnancy. A cross-sectional study was conducted among pregnant women who attended antenatal clinic at four different health facilities in Ghana.

Larval habitat diversity and Anopheles mosquito species distribution in different ecological zones in Ghana

April 14, 2021 - 16:47 -- Open Access
Hinne IA, Attah SK, Mensah BA, Forson AO, Afrane YA
Parasit Vectors. 2021 Apr 7;14(1):193

Understanding the ecology of larval malaria and lymphatic filariasis mosquitoes in a changing environment is important in developing effective control tools or programmes. This study characterized the breeding habitats of Anopheles mosquitoes in rural communities in different ecological zones in Ghana during the dry and rainy seasons.

Temporal evolution of sulfadoxine-pyrimethamine resistance genotypes and genetic diversity in response to a decade of increased interventions against Plasmodium falciparum in northern Ghana

March 18, 2021 - 09:27 -- Open Access
Lucas N. Amenga-Etego, Victor Asoala, Godfred Agongo, Christopher Jacob, Sonia Goncalves, Gordon A. Awandare, Kirk A. Rockett and Dominic Kwiatkowski
Malaria Journal 2021 20:152, 17 March 2021

Anti-malarial drug resistance remains a key concern for the global fight against malaria. In Ghana sulfadoxine-pyrimethamine (SP) is used for intermittent preventive treatment of malaria in pregnancy and combined with amodiaquine for Seasonal Malaria Chemoprevention (SMC) during the high malaria season. Thus, surveillance of molecular markers of SP resistance is important to guide decision-making for these interventions in Ghana.

High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana

February 20, 2021 - 08:35 -- Open Access
Charles A. Brown, Prince J. Pappoe-Ashong, Nancy Duah, Anita Ghansah, Harry Asmah, Edwin Afari and Kwadwo A. Koram
Malaria Journal 2021 20:99, 17 February 2021

Recent studies from different malaria-endemic regions including western Africa have now shown that Plasmodium vivax can infect red blood cells (RBCs) and cause clinical disease in Duffy-negative people, though the Duffy-negative phenotype was thought to confer complete refractoriness against blood invasion with P. vivax. The actual prevalence of P. vivax in local populations in Ghana is unknown and little information is available about the distribution of Duffy genotypes. The aim of this study was to assess the prevalence of P. vivax in both asymptomatic and symptomatic outpatients and the distribution of Duffy genotypes in Ghana.

Bloodstream infection with Acinetobacter baumanii in a Plasmodium falciparum positive infant: a case report

February 8, 2021 - 10:24 -- Open Access
Akenten CW, Boahen KG, Marfo KS, Sarpong N, Dekker D, Struck NS, Osei-Tutu L, May J, Amuasi JH, Eibach D
J Med Case Rep. 2021 Feb 5;15(1):46

The increasing incidence of multi-antibiotic-resistant bacterial infections, coupled with the risk of co-infections in malaria-endemic regions, complicates accurate diagnosis and prolongs hospitalization, thereby increasing the total cost of illness. Further, there are challenges in making the correct choice of antibiotic treatment and duration, precipitated by a lack of access to microbial culture facilities in many hospitals in Ghana. The aim of this case report is to highlight the need for blood cultures or alternative rapid tests to be performed routinely in malaria patients, to diagnose co-infections with bacteria, especially when symptoms persist after antimalarial treatment.

Malaria parasitaemia and mRDT diagnostic performances among symptomatic individuals in selected health care facilities across Ghana

February 3, 2021 - 14:09 -- Open Access
Abuaku B, Amoah LE, Peprah NY, Asamoah A, Amoako EO, Donu D, Adu GA, Malm KL
BMC Public Health. 2021 Jan 28;21(1):239

Parasitological diagnosis generates data to assist malaria-endemic countries determine their status within the malaria elimination continuum and also inform the deployment of proven interventions to yield maximum impact. This study determined prevalence of malaria parasitaemia and mRDT performances among febrile patients in selected health care facilities across Ghana.

Householders' perception about sustaining the useful life of long-lasting insecticide-treated nets in Ghana

January 20, 2021 - 07:19 -- Open Access
Opoku R, Amoah PA, Nyamekye KA
Int Health. 2021 Jan 14;13(1):57-62

This article explores the multifaceted perceptions among householders about the care, efficacy and disposal of long-lasting insecticide-treated nets (LLINs), especially those regarding the end of the useful life of LLINs, and their implications for malaria control.

Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

January 9, 2021 - 13:17 -- Open Access
Thomas A. Anyorigiya, Sandra Castel, Karen I. Barnes, et al.
Malaria Journal 2021 20:18, 6 January 2021

Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal anti-malarial dosing in key target population groups.

NOT Open Access | High Prevalence of Molecular Markers of Plasmodium falciparum Resistance to Sulphadoxine-Pyrimethamine in Parts of Ghana: A Threat to ITPTp-SP

January 7, 2021 - 10:28 -- NOT Open Access
Afutu LL, Boampong JN, Quashie NB
J Trop Pediatr. 2021 Jan 6:fmaa120

Malaria in pregnancy is a huge public health problem as it is the cause of maternal anaemia, still birth, premature delivery, low birth weight among others. To tackle this problem, WHO recommended the administration, during pregnancy, of intermittent preventive treatment with sulphadoxine–pyrimethamine (IPTp-SP). The introduction of this policy is likely to create SP drug pressure which may lead to the emergence of parasite strains resistant to the drug.

A Case of Plasmodium falciparum Malaria Treated with Artesunate in a 55-Year-Old Woman on Return to Florida from a Visit to Ghana

December 23, 2020 - 09:51 -- Open Access
Rodriguez JA, Roa AA, Leonso-Bravo AA, Khatiwada P, Eckardt P, Lemos-Ramirez
Am J Case Rep. 2020 Dec 20;21:e926097

Malaria is the infection caused by inoculation with the mostly obligate intraerythrocytic protozoa of the genus Plasmodium. Severe malaria manifests as multiple organ dysfunction with high parasitemia counts characterized by coma, stupor, and severe metabolic acidosis. Physicians in the United States do not frequently encounter patients with malaria, and the drugs are only available through the Centers for Disease Control and Prevention, which makes the management of this disease somewhat complicated. In 2019, the marketing of quinine for malaria was discontinued. In May 2020, the US Food and Drug Administration approved the use of intravenous artesunate for the treatment of adults and children with severe malaria.


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