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NOT Open Access | Evolution of antimalarial drug resistance markers in the reservoir of Plasmodium falciparum infections in the Upper East Region of Ghana

May 29, 2020 - 14:38 -- NOT Open Access
Narh CA, Ghansah A, Duffy MF, Ruybal-Pesántez S, Onwona CO, Oduro AR, Koram KA, Day KP, Tiedje KE
J Infect Dis. 2020 May 27:jiaa286

The majority of Plasmodium falciparum infections, constituting the reservoir in all ages, are asymptomatic in high transmission settings in Africa. The role of this reservoir in the evolution and spread of drug resistance was explored.

Improving the effectiveness of point of care tests for malaria and anaemia: a qualitative study across three Ghanaian antenatal clinics

May 21, 2020 - 06:37 -- Open Access
Palmer T, Aiyenigba AO, Bates I, Okyere DD, Tagbor H, Ampofo GD
BMC Health Serv Res. 2020 May 19; 20(1):444

Anaemia and malaria are both major contributors to maternal and child mortality, and morbidity, with some of the worst outcomes occurring in sub-Saharan Africa. Point of care tests (POCT), if used appropriately, provide a simple, inexpensive form of diagnostic testing, as a reliable alternative when laboratory tests are not readily available. In such resource limited settings, clinical staff tend to rely on symptom-based diagnosis and presumptive treatment. This study uses qualitative methods to identify the current practice of POCT use for malaria and anaemia, to explore the enablers and barriers to effective implementation of these POCT, and to determine how relationships between each of the stakeholder groups may impact on POCT use.

An exploratory study of the acceptability of indoor residual spraying for malaria control in upper western Ghana

April 10, 2020 - 16:46 -- Open Access
Suuron VM, Mwanri L, Tsourtos G, Owusu-Addo E
BMC Public Health. 2020 Apr 6;20(1):465

Despite the implementation of the World Health Organisation’s recommended indoor residual spraying (IRS) intervention in the upper west region of Ghana to reduce malaria morbidity and mortality, the uptake of this intervention remains low. This study explores the facilitators and barriers to the acceptability and community uptake of indoor residual spraying in a highly endemic region of Ghana.

NOT Open Access | Antimalarial Drug Resistance Profiling of Plasmodium falciparum Infections in Ghana Using Molecular Inversion Probes and Next-Generation Sequencing

March 30, 2020 - 10:49 -- NOT Open Access
Mensah BA, Aydemir O, Myers-Hansen JL, Opoku M, Hathaway NJ, Marsh PW, Anto F, Bailey J, Abuaku B, Ghansah A
Antimicrob Agents Chemother. 2020 Mar 24;64(4). pii: e01423-19

A key drawback to monitoring the emergence and spread of antimalarial drug resistance in sub-Saharan Africa is early detection and containment. Next-generation sequencing methods offer the resolution, sensitivity, and scale required to fill this gap by surveilling for molecular markers of drug resistance.

NOT Open Access | Peripheral Merozoite Surface Proteins Are Targets of Naturally Acquired Immunity against Malaria in both India and Ghana

March 30, 2020 - 10:37 -- NOT Open Access
Garcia-Senosiain A, Kana IH, Singh SK, Chourasia BK, Das MK, Dodoo D, Singh S, Adu B, Theisen M
Infect Immun. 2020 Mar 23;88(4). pii: e00778-19

Development of a successful blood-stage vaccine against Plasmodium falciparum malaria remains a high priority. Immune-epidemiological studies are effective tools for the identification of antigenic targets of naturally acquired immunity (NAI) against malaria. However, differences in study design and methodology may compromise interstudy comparisons.

Effect of pre-consultation testing on clinicians’ adherence to malaria test results and waiting time among children under 5 years in the Northern Zone of Volta Region of Ghana

March 24, 2020 - 11:45 -- Open Access
Jonathan Mawutor Gmanyami, Asiwome Ameko, Saviour Selase Ahiafe, Samuel Adolf Bosoka, Margaret Kweku and Evelyn Korkor Ansah
Malaria Journal 2020 19:120, 20 March 2020

The Ministry of Health, Ghana, in accordance with global policy, recommends that all suspected malaria cases be confirmed parasitologically before treatment. Not all clinicians, however, base their treatment on test results. Patients also spend a lot of time at health facilities waiting to consult a clinician before being asked to go for testing and to see a clinician with test results. The purpose of the study was to determine if testing all children aged 6 to 59 months with fever reporting at an outpatients department (OPD) for malaria before consultation with a clinician (pre-consultation testing) will influence clinicians to adhere to test results and also reduce the time spent by such patients.

NOT Open Access | Immunogenicity and safety of the RTS,S/AS01 malaria vaccine co-administered with measles, rubella and yellow fever vaccines in Ghanaian children: A phase IIIb, multi-center, non-inferiority, randomized, open, controlled trial

March 23, 2020 - 14:50 -- NOT Open Access
Asante KP, Ansong D, Ofori-Anyinam O, et al.
Vaccine. 2020 Mar 16. pii: S0264-410X(20)30358-3

To optimize vaccine implementation visits for young children, it could be efficient to administer the first RTS,S/AS01 malaria vaccine dose during the Expanded Programme on Immunization (EPI) visit at 6 months of age together with Vitamin A supplementation and the third RTS,S/AS01 dose on the same day as yellow fever (YF), measles and rubella vaccines at 9 months of age. We evaluated the safety and immunogenicity of RTS,S/AS01 when co-administered with YF and combined measles-rubella (MR) vaccines.

NOT Open Access | Effect of drug pressure on promoting the emergence of antimalarial resistant parasites among pregnant women in Ghana

March 19, 2020 - 09:16 -- NOT Open Access
Tornyigah B, Coppée R, Houze P, Kusi KA, Adu B, Quakyi I, Coleman N, Mama A, Deloron P, Anang AK, Clain J, Tahar R, Ofori MF, Ndam NT
Antimicrob Agents Chemother. 2020 Mar 16. pii: AAC.02029-19

Continuous spread of antimalarial drug resistance is a threat to current chemotherapy efficacy. Therefore, characterizing the genetic diversity of drug resistance markers is needed to follow treatment effectiveness and further update control strategies. Here, we genotyped Plasmodium falciparum resistance gene markers associated with sulfadoxine-pyrimethamine (SP) and artemisinin-based combination therapy (ACT) in isolates from pregnant women in Ghana.

NOT Open Access | Ethnomedicinal survey and mutagenic studies of plants used in Accra metropolis, Ghana

February 17, 2020 - 12:12 -- NOT Open Access
Oppong Bekoe E, Agyare C, Nyarko A, et al.
Journal of Ethnopharmacology, Volume 248, 10 February 2020, 112309

Majority of people living in Ghana and many other developing countries rely on traditional medicinal plants for their primary healthcare. These plants are used either alone or in combination to manage a wide range of ailments. However, most of these plants have not been investigated for their mutagenic effects.

Stage-specific Plasmodium falciparum immune responses in afebrile adults and children living in the Greater Accra Region of Ghana

February 14, 2020 - 16:32 -- Open Access
Festus K. Acquah, Aminata C. Lo, Kwadwo Akyea-Mensah, Hamza B. Abagna, Babacar Faye, Michael Theisen, Ben A. Gyan and Linda E. Amoah
Malaria Journal 2020 19:64, 10 February 2020

Asymptomatic carriage of Plasmodium falciparum is widespread in adults and children living in malaria-endemic countries. This study identified the prevalence of malaria parasites and the corresponding levels of naturally acquired anti-parasite antibody levels in afebrile adults living in two communities in the Greater Accra Region of Ghana.


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