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vaccination

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01(E) vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention

September 16, 2020 - 13:13 -- Open Access
Author(s): 
Chandramohan D, Dicko A, Greenwood B, et al.
Reference: 
BMJ Open. 2020 Sep 15;10(9):e035433

Seasonal malaria chemoprevention (SMC), with sulphadoxine-pyrimethamine plus amodiaquine (SP+AQ) is effective but does not provide complete protection against clinical malaria. The RTS,S/AS01E malaria vaccine provides a high level of protection shortly after vaccination, but this wanes rapidly. Such a vaccine could be an alternative or additive to SMC. This trial aims to determine whether seasonal vaccination with RTS,S/AS01E vaccine could be an alternative to SMC and whether a combination of the two interventions would provide added benefits.

Comparison of ELISA with electro-chemiluminescence technology for the qualitative and quantitative assessment of serological responses to vaccination

April 20, 2020 - 09:47 -- Open Access
Author(s): 
Jessica S. Bolton, Sidhartha Chaudhury, Sheetij Dutta, Scott Gregory, Emily Locke, Tony Pierson and Elke S. Bergmann-Leitner
Reference: 
Malaria Journal 2020 19:159, 17 April 2020

Profiling immune responses induced by either infection or vaccination can provide insight into identification of correlates of protection. Furthermore, profiling of serological responses can be used to identify biomarkers indicative of exposure to pathogens. Conducting such immune surveillance requires readout methods that are high-throughput, robust, and require small sample volumes. While the enzyme-linked immunosorbent assay (ELISA) is the classical readout method for assessing serological responses, the advent of multiplex assays has significantly increased the throughput and capacity for immunoprofiling. This report describes the development and assay performance (sensitivity, linearity of detection, requirement for multiple dilutions for each sample, intra- and inter-assay variability) of an electro-chemiluminescence (ECLIA)-based multiplex assay.

Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination

March 9, 2020 - 15:03 -- Open Access
Author(s): 
Bailey JA, Berry AA, Plowe CV, et al.
Reference: 
Sci Rep. 2020 Mar 3;10(1):3952

Vaccines based on Plasmodium falciparum apical membrane antigen 1 (AMA1) have failed due to extensive polymorphism in AMA1. To assess the strain-specificity of antibody responses to malaria infection and AMA1 vaccination, we designed protein and peptide microarrays representing hundreds of unique AMA1 variants. Following clinical malaria episodes, children had short-lived, sequence-independent increases in average whole-protein seroreactivity, as well as strain-specific responses to peptides representing diverse epitopes.

Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against Plasmodium falciparum parasites in preclinical in vitro and in vivo models

February 11, 2020 - 16:23 -- Open Access
Author(s): 
Marco Tamborrini, Julia Hauser, Anja Schäfer, Mario Amacker, Paola Favuzza, Kwak Kyungtak, Sylvain Fleury, Gerd Pluschke
Reference: 
NPJ Vaccines. 2020; 5:9

The Plasmodium falciparum (Pf) cysteine-rich protective antigen (PfCyRPA) has emerged as a promising blood-stage candidate antigen for inclusion into a broadly cross-reactive malaria vaccine. This highly conserved protein among various geographical strains plays a key role in the red blood cell invasion process by P. falciparum merozoites, and antibodies against PfCyRPA can efficiently prevent the entry of the malaria parasites into red blood cells.

Vaccination accelerates hepatic erythroblastosis induced by blood-stage malaria

February 3, 2020 - 17:05 -- Open Access
Author(s): 
Denis Delic, Frank Wunderlich, Saleh Al-Quraishy, Abdel-Azeem S. Abdel-Baki, Mohamed A. Dkhil and Marcos J. Araúzo-Bravo
Reference: 
Malaria Journal 2020 19:49, 29 January 2020

Vaccination induces survival of otherwise lethal blood-stage infections of the experimental malaria Plasmodium chabaudi. Blood-stage malaria induces extramedullary erythropoiesis in the liver. This study investigates how vaccination affects the course of malaria-induced expression of erythrocytic genes in the liver.

The Costs of Implementing Vaccination With the RTS,S Malaria Vaccine in Five Sub-Saharan African Countries

January 14, 2020 - 16:32 -- Open Access
Author(s): 
Sicuri E, Yaya Bocoum F, Nonvignon J, Alonso S, Fakih B, Bonsu G, Kariuki S, Leeuwenkamp O, Munguambe K, Mrisho M, Were V, Sauboin C
Reference: 
MDM Policy & Practice, 2019 Dec 19;4(2):2381468319896280

The World Health Organization has recommended pilot implementation of a candidate vaccine against malaria (RTS,S/AS01) in selected sub-Saharan African countries. This exploratory study aimed to estimate the costs of implementing RTS,S in Burkina Faso, Ghana, Kenya, Mozambique, and Tanzania.

'Breakthrough' of the week: Flying syringes

March 19, 2010 - 12:29 -- Bart G.J. Knols

In the early 1990s, when scientists first came up with a radical new idea to engineer mosquitoes that would no longer be capable of transmitting pathogens, some thought of an even more fantastic application. Use mosquitoes to vaccinate people. Silence followed until now...

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