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Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017

May 6, 2021 - 07:24 -- Open Access
Toussaint Rouamba, Sékou Samadoulougou, Mady Ouédraogo, Hervé Hien, Halidou Tinto and Fati Kirakoya-Samadoulougou
Malaria Journal 2021 20:211, 1 May 2021

Malaria in endemic countries is often asymptomatic during pregnancy, but it has substantial consequences for both the mother and her unborn baby. During pregnancy, anaemia is an important consequence of malaria infection. In Burkina Faso, the intensity of malaria varies according to the season, albeit the prevalence of malaria and anaemia as well as their risk factors, during high and low malaria transmission seasons is underexplored at the household level.

NOT Open Access | Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei

May 5, 2021 - 11:01 -- NOT Open Access
Usman MA, Usman FI, Abubakar MS, Salman AA, Adamu A, Ibrahim MA
Exp Parasitol. 2021 May;224:108097

The quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium falciparum under in vitro condition. On this basis, the in vivo anti-Plasmodium berghei activity of phytol including the ameliorative effects of the compound on P. berghei-associated anaemia and organ damage were investigated.

Intermittent preventive treatment comparing two versus three doses of sulphadoxine pyrimethamine (IPTp-SP) in the prevention of anaemia in pregnancy in Ghana: A cross-sectional study

April 22, 2021 - 08:21 -- Open Access
Agyeman YN, Newton S, Annor RB, Owusu-Dabo E
PLoS One. 2021 Apr 20;16(4):e0250350

In 2012 the World Health Organisation (WHO) revised the policy on Intermittent Preventive Treatment with Sulphadoxine Pyrimethamine (IPTp-SP) to at least three doses for improved protection against malaria parasitaemia and its associated effects such as anaemia during pregnancy. We assessed the different SP dosage regimen available under the new policy to determine the dose at which women obtained optimal protection against anaemia during pregnancy. A cross-sectional study was conducted among pregnant women who attended antenatal clinic at four different health facilities in Ghana.

Malaria and intestinal parasite co-infection and its association with anaemia among people living with HIV in Buea, Southwest Cameroon: A community-based retrospective cohort study

January 27, 2021 - 10:45 -- Open Access
Mekachie Sandie S, Sumbele IUN, Tasah MM, Kimbi HK
PLoS One. 2021 Jan 22;16(1):e0245743

Both malaria and intestinal parasites are endemic in Cameroon, and their co-infection can be of great impact on anaemia among people living with HIV (PLWH). This community-based retrospective cohort study determined the prevalence and association of infections with anaemia in PLWH and HIV-negative individuals in Buea, Cameroon from March to August 2019.

NOT Open Access | Delayed haemolysis following artesunate in a child with profound anaemia and Coca-Cola-coloured urine

December 23, 2020 - 08:27 -- NOT Open Access
Patel N, Thomson J, Re Ferre L
BMJ Case Rep. 2020 Dec 17;13(12):e238361

An 8-year-old girl of African descent presented to the hospital with a headache, lethargy, pallor and 'Coca-Cola'-coloured urine. She had been admitted 11 days before with Plasmodium falciparum malaria, which was successfully treated with 48 hours of parenteral artesunate. Investigations revealed signs of severe haemolytic anaemia, with a haemoglobin level of 52 g/L that reached a nadir of 10 g/L within 4 hours, in addition to haemoglobinuria, hyperbilirubinaemia and raised lactate dehydrogenase levels.

Copula geoadditive modelling of anaemia and malaria in young children in Kenya, Malawi, Tanzania and Uganda

November 10, 2020 - 13:46 -- Open Access
Roberts DJ, Zewotir T
J Health Popul Nutr. 2020 Nov 6;39(1):8

Anaemia and malaria are the leading causes of sub-Saharan African childhood morbidity and mortality. This study aimed to explore the complex relationship between anaemia and malaria in young children across the districts or counties of four contiguous sub-Saharan African countries, namely Kenya, Malawi, Tanzania and Uganda, while accounting for the effects of socio-economic, demographic and environmental factors. Geospatial maps were constructed to visualise the relationship between the two responses across the districts of the countries.

Uncomplicated falciparum malaria among schoolchildren in Bajil district of Hodeidah governorate, west of Yemen: association with anaemia and underweight

October 8, 2020 - 08:12 -- Open Access
Talal S. Alwajeeh, Rashad Abdul-Ghani, Amal F. Allam, Hoda F. Farag, Safia S. M. Khalil, Amel Y. Shehab, Mona H. El-Sayad, Raed A. Alharbi, Shaia S. R. Almalki and Ahmed A. Azazy
Malaria Journal 2020 19:358, 7 October 2020

Malaria, malnutrition and anaemia are major public health problems in Yemen, with Hodeidah being the most malaria-afflicted governorate. To address the lack of relevant studies, this study was conducted to determine the prevalence of Plasmodium falciparum and its relation to nutritional status and haematological indices among schoolchildren in Bajil district of Hodeidah governorate, west of Yemen.

Highlighting the burden of malarial infection and disease in the neonatal period: making sense of different concepts

September 1, 2020 - 09:59 -- Open Access
Abel Nhama, Rosauro Varo and Quique Bassat
Malaria Journal 2020 19:311, 28 August 2020

In malaria-endemic areas, the first year of life is indisputably considered one of the most vulnerable periods for malaria disease, and malaria-associated mortality in this age group is typically high, usually as a consequence of severe anaemia, among other possible complications.

Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children

June 12, 2020 - 13:58 -- Open Access
Abuga KM, Rockett KA, Muriuki JM, Koch O, Nairz M, Sirugo G, Bejon P, Kwiatkowski DP, Prentice AM, Atkinson SH
Wellcome Open Res. 2020 Jun 2; 5:40

Anaemia is a major public health concern especially in African children living in malaria-endemic regions. Interferon-gamma (IFN-γ) is elevated during malaria infection and is thought to influence erythropoiesis and iron status. Genetic variants in the IFN-γ gene (IFNG) are associated with increased IFN-γ production. We investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes of IFNG in relation to nutritional iron status and anaemia in Gambian children over a malaria season.

Improving the effectiveness of point of care tests for malaria and anaemia: a qualitative study across three Ghanaian antenatal clinics

May 21, 2020 - 06:37 -- Open Access
Palmer T, Aiyenigba AO, Bates I, Okyere DD, Tagbor H, Ampofo GD
BMC Health Serv Res. 2020 May 19; 20(1):444

Anaemia and malaria are both major contributors to maternal and child mortality, and morbidity, with some of the worst outcomes occurring in sub-Saharan Africa. Point of care tests (POCT), if used appropriately, provide a simple, inexpensive form of diagnostic testing, as a reliable alternative when laboratory tests are not readily available. In such resource limited settings, clinical staff tend to rely on symptom-based diagnosis and presumptive treatment. This study uses qualitative methods to identify the current practice of POCT use for malaria and anaemia, to explore the enablers and barriers to effective implementation of these POCT, and to determine how relationships between each of the stakeholder groups may impact on POCT use.


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