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Malaysia

Risk factor of plasmodium knowlesi infection in Sabah Borneo Malaysia, 2020: A population-based case-control study

September 14, 2021 - 15:07 -- Open Access
Author(s): 
Chin AZ, Avoi R, Atil A, Awang Lukman K, Syed Abdul Rahim SS, Ibrahim MY, Ahmed K, Jeffree MS
Reference: 
PLoS One. 2021 Sep 10;16(9):e0257104

In the Malaysian state of Sabah, P. knowlesi notifications increased from 2% (59/2,741) of total malaria notifications in 2004 to 98% (2030/2,078) in 2017. There was a gap regarding P. knowlesi acquisition risk factors related to practice specifically in working age group. The main objective of this study was to identify the risk factors for acquiring P. knowlesi infection in Sabah among the working age group.

High incidence of Plasmodium knowlesi malaria compared to other human malaria species in several hospitals in Malaysia

September 1, 2021 - 17:35 -- Open Access
Author(s): 
Lai MY, Rafieqin N, Lau YL, et al.
Reference: 
Trop Biomed. 2021 Sep 1;38(3):248-253

Through the regional control programme, Malaysia has been successfully reducing the incidence of Plasmodium falciparum and Plasmodium vivax infections. However, the incidence of zoonotic malaria Plasmodium knowlesi infection is increasing and now has been the major cause of malaria in Malaysia especially Malaysian Borneo. The emergence of knowlesi infection has threatened the malaria elimination programme which the government aims to reduce the overall malaria infections by 2020. Unlike other benign human Plasmodium spp., P. knowlesi can cause fatal infections.

Natural Human Infections with Plasmodium cynomolgi, P. inui, and 4 other Simian Malaria Parasites, Malaysia

August 4, 2021 - 12:25 -- Open Access
Author(s): 
Yap NJ, Hossain H, Nada-Raja T, Ngui R, Muslim A, Hoh BP, Khaw LT, Kadir KA, Simon Divis PC, Vythilingam I, Singh B, Lim YA
Reference: 
Emerg Infect Dis. 2021 Aug;27(8):2187-2191

We detected the simian malaria parasites Plasmodium knowlesi, P. cynomolgi, P. inui, P. coatneyi, P. inui-like, and P. simiovale among forest fringe-living indigenous communities from various locations in Malaysia. Our findings underscore the importance of using molecular tools to identify newly emergent malaria parasites in humans.

NOT Open Access | The pharmacokinetic properties of artemether and lumefantrine in Malaysian patients with Plasmodium knowlesi malaria

July 28, 2021 - 14:05 -- NOT Open Access
Author(s): 
Sugiarto SR, Singh B, Page-Sharp M, Davis WA, Salman S, Hii KC, Davis TME
Reference: 
Br J Clin Pharmacol. 2021 Jul 23

To assess the pharmacokinetic properties of artemether, lumefantrine and their active metabolites in Plasmodium knowlesi malaria.

High incidence of asymptomatic cases during an outbreak of Plasmodium malariae in a remote village of Malaysian Borneo

June 9, 2021 - 07:14 -- Open Access
Author(s): 
Binti Naserrudin NA, Binti Abdul Aziz EI, Aljet E, Mangunji G, Tojo B, Jeffree MS, Culleton R, Ahmed K
Reference: 
PLoS Negl Trop Dis. 2021 Jun 3;15(6):e0009450

An outbreak of Plasmodium malariae occurred in Sonsogon Paliu village in the remote area of Ulu Bengkoka sub-district of Kota Marudu, Northern Sabah, Malaysian Borneo from July through August 2019. This was the first outbreak of malaria in this village since 2014. On 11th July 2019 the Kota Kinabalu Public Health Laboratory notified the Kota Marudu District Health Office of a Polymerase Chain Reaction (PCR) positive case of P. malariae. This index case was a male from Sulawesi, Indonesia working for a logging company operating in Sonsogon Paliu. During the resulting outbreak, a total of 14 symptomatic cases were detected.

Perceptions and prevention practices on malaria among the indigenous Orang Asli community in Kelantan, Peninsular Malaysia

April 28, 2021 - 15:54 -- Open Access
Author(s): 
Mohd Bakhtiar Munajat, Mohd Amirul Fitri A. Rahim, Zulkarnain Md Idris, et al.
Reference: 
Malaria Journal 2021 20:202, 27 April 2021

Malaysia is on track towards malaria elimination. However, several cases of malaria still occur in the country. Contributing factors and communal aspects have noteworthy effects on any malaria elimination activities. Thus, assessing the community’s knowledge, attitudes and practices (KAP) towards malaria is essential. This study was performed to evaluate KAP regarding malaria among the indigenous people (i.e. Orang Asli) in Peninsular Malaysia.

NOT Open Access | Spatial and Temporal Patterns of Plasmodium knowlesi Malaria in Sarawak from 2008 to 2017

March 24, 2021 - 14:14 -- NOT Open Access
Author(s): 
Ooi CH, Phang WK, Kent Liew JW, Lau YL
Reference: 
Am J Trop Med Hyg. 2021 Mar 22:tpmd201304

Zoonotic knowlesi malaria has replaced human malaria as the most prevalent malaria disease in Malaysia. The persistence of knowlesi malaria in high-risk transmission areas or hotspots can be discouraging to existing malaria elimination efforts. In this study, retrospective data of laboratory-confirmed knowlesi malaria cases were obtained from the Sarawak Health Department to investigate the spatiotemporal patterns and clustering of knowlesi malaria in the state of Sarawak from 2008 to 2017.

Malaria elimination in Malaysia and the rising threat of Plasmodium knowlesi

November 25, 2020 - 12:08 -- Open Access
Author(s): 
Chin AZ, Maluda MCM, Jelip J, Jeffree MSB, Culleton R, Ahmed K
Reference: 
J Physiol Anthropol. 2020 Nov 23;39(1):36

Malaria is a major public-health problem, with over 40% of the world’s population (more than 3.3 billion people) at risk from the disease. Malaysia has committed to eliminate indigenous human malaria transmission by 2020. The objective of this descriptive study is to understand the epidemiology of malaria in Malaysia from 2000 through 2018 and to highlight the threat posed by zoonotic malaria to the National Malaria Elimination Strategic Plan.

NOT Open Access | Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia

November 4, 2020 - 15:51 -- NOT Open Access
Author(s): 
Amir A, Shahari S, Liew JWK, de Silva JR, Khan MB, Lai MY, Snounou G, Abdullah ML, Gani M, Rovie-Ryan JJ, Lau YL
Reference: 
Acta Trop. 2020 Nov;211:105596

Zoonotic cases of Plasmodium knowlesi account for most malaria cases in Malaysia, and humans infected with P. cynomolgi, another parasite of macaques have recently been reported in Sarawak. To date the epidemiology of malaria in its natural Macaca reservoir hosts remains little investigated. In this study we surveyed the prevalence of simian malaria in wild macaques of three states in Peninsular Malaysia, namely Pahang, Perak and Johor using blood samples from 103 wild macaques (collected by the Department of Wildlife and National Parks Peninsular Malaysia) subjected to microscopic examination and nested PCR targeting the Plasmodium small subunit ribosomal RNA gene.

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