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NOT Open Access | Plasmodium vivax drug resistance markers: Genetic polymorphisms and mutation patterns in isolates from Malaysia

March 25, 2020 - 14:53 -- NOT Open Access
Cheong FW, Dzul S, Fong MY, Lau YL, Ponnampalavanar S
Acta Trop. 2020 Mar 20:105454

Transmission of Plasmodium vivax still persist in Malaysia despite the government's aim to eliminate malaria in 2020. High treatment failure rate of chloroquine monotherapy was reported recently. Hence, parasite drug susceptibility should be kept under close monitoring. Mutation analysis of the drug resistance markers is useful for reconnaissance of anti-malarial drug resistance. Hitherto, information on P. vivax drug resistance marker in Malaysia are limited.

Updates on malaria incidence and profile in Malaysia from 2013 to 2017

February 10, 2020 - 15:58 -- Open Access
Narwani Hussin, Yvonne Ai-Lian Lim, Pik Pin Goh, Timothy William, Jenarun Jelip and Rose Nani Mudin
Malaria Journal 2020 19:55, 31 January 2020

To date, most of the recent publications on malaria in Malaysia were conducted in Sabah, East Malaysia focusing on the emergence of Plasmodium knowlesi. This analysis aims to describe the incidence, mortality and case fatality rate of malaria caused by all Plasmodium species between Peninsular Malaysia and East Malaysia (Sabah and Sarawak) over a 5-year period (2013–2017).

Plasmodium knowlesi Malaria in Sabah, Malaysia, 2015-2017: Ongoing Increase in Incidence Despite Near-elimination of the Human-only Plasmodium Species

January 20, 2020 - 16:11 -- Open Access
Cooper DJ, Rajahram GS, Barber BE, et al.
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 361–367

Malaysia aims to eliminate malaria by 2020. However, while cases of Plasmodium falciparum and Plasmodium vivax have decreased substantially, the incidence of zoonotic malaria from Plasmodium knowlesi continues to increase, presenting a major challenge to regional malaria control efforts. Here we report incidence of all Plasmodium species in Sabah, including zoonotic P. knowlesi, during 2015–2017.

Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia

November 30, 2019 - 04:44 -- Open Access
Ahmed MA, Saif A, Quan FS
PLoS One. 2019 Nov 21;14(11):e0224743.

Human infections due to the monkey malaria parasite Plasmodium knowlesi are increasingly being reported from Malaysia. The parasite causes high parasitaemia, severe and fatal malaria in humans thus there is a need for urgent measures for its control.


Not Open Access | Plasmodium knowlesi: The emerging zoonotic malaria parasite

December 30, 2012 - 17:24 -- NOT Open Access
Spinello Antinori, Laura Galimberti, Laura Milazzo, Mario Corbellino
Acta Tropica, Volume 125, Issue 2, February 2013, Pages 191-201

In the following years several reports showed that P. knowlesi is much more widespread than initially thought with cases reported across Southeast Asia.

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