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parasite

Ahead of the curve: next generation estimators of drug resistance in malaria infections

June 28, 2013 - 18:24 -- Open Access
Author(s): 
Nicole Mideo, David A. Kennedy, Jane M. Carlton, Jeffrey A. Bailey, Jonathan J. Juliano, Andrew F. Read
Reference: 
Trends in Parasitology, Volume 29, Issue 7, July 2013, Pages 321-328
MalariaWorld

A key challenge is detecting the early signs of drug resistance when little is known about its genetic basis. Focusing on malaria parasites, we propose a way to do this.

Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy

June 28, 2013 - 18:21 -- Open Access
Author(s): 
Sanjeev Krishna, Peter Gottfried Kremsner
Reference: 
Trends in Parasitology, Volume 29, Issue 7, July 2013, Pages 313-317
MalariaWorld

This opinion article reviews the mechanisms underlying parasite clearance after artemisinin treatment and how these might relate to in vitro methods to assay for resistance.

Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children

January 13, 2013 - 13:44 -- Open Access
Author(s): 
Koukouikila-Koussounda F, Ntoumi F, Ndounga M, Tong HV, Abena A, Velavan TP
Reference: 
Malaria Journal 2013, 12:9 (8 January 2013)
MalariaWorld

The study indicated that the STAT6 promoter polymorphism rs3024944 was associated with uncomplicated malaria, whereas the FOXP3 promoter variant rs11091253 was associated with significant P. falciparum parasitaemia levels.

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Review: Sustainable malaria control: transdisciplinary approaches for translational applications

December 30, 2012 - 16:43 -- Open Access
Author(s): 
Birkholtz L, Bornman R, Focke W, Mutero C, Jager C
Reference: 
Malaria Journal 2012, 11:431 (26 December 2012)
MalariaWorld

Here, an overview of malaria control and elimination strategies is provided and the sustainability of each in context of vector- and parasite control is assessed. From this, it can be concluded that transdisciplinary approaches are essential for sustained malaria control and elimination in malaria-endemic communities.

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