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parasite

The nuclear 18S ribosomal DNAs of avian haemosporidian parasites

September 10, 2019 - 15:36 -- Open Access
Author(s): 
Josef Harl, Tanja Himmel, Gediminas Valkiūnas and Herbert Weissenböck
Reference: 
Malaria Journal 2019 18:305, 3 September 2019

Plasmodium species feature only four to eight nuclear ribosomal units on different chromosomes, which are assumed to evolve independently according to a birth-and-death model, in which new variants originate by duplication and others are deleted throughout time. Moreover, distinct ribosomal units were shown to be expressed during different developmental stages in the vertebrate and mosquito hosts. Here, the 18S rDNA sequences of 32 species of avian haemosporidian parasites are reported and compared to those of simian and rodent Plasmodium species.

Landscape and dynamics of transcription initiation in the malaria parasite Plasmodium falciparum

March 12, 2016 - 10:52 -- Open Access
Author(s): 
Sophie Adjalley, Christophe Chabbert, Bernd Klaus, Vicent Pelechano, Lars Steinmetz
Reference: 
Cell Reports 14, 1–13, March 15, 2016

This detailed analysis of TSS usage enabled us to define architectural features of plasmodial promoters. We demonstrate that TSS selection and strength are constrained by local nucleotide composition.

Epidemiological traits of the malaria-like parasite Polychromophilus murinus in the Daubenton’s bat Myotis daubentonii

December 17, 2014 - 16:56 -- Open Access
Author(s): 
Fardo Witsenburg, Franziska Schneider, Philippe Christe
Reference: 
Parasites & Vectors 2014, 7:566 (9 December 2014)

Polychromophilus murinus, a malaria-like blood parasite, specialised on temperate-zone bats is a species that is being ‘rediscovered’. This study describes the infection dynamics over time and between host sex and age classes.

Not Open Access | Purification of a recombinant histidine-tagged lactate dehydrogenase from the malaria parasite, Plasmodium vivax, and characterization of its properties

November 5, 2014 - 17:48 -- NOT Open Access
Author(s): 
Balamurugan Sundaram, Nandan Mysore Varadarajan, Pradeep Annamalai Subramani, Susanta Kumar Ghosh, Viswanathan Arun Nagaraj
Reference: 
Biotechnology Letters, Volume 36, Issue 12, pp 2473-2480

The recombinant PvLDH was reactive in lateral flow immunochromatographic assays detecting pan- and vivax-specific LDH. The soluble recombinant PvLDH purified using heterologous expression system can facilitate the generation of vivax LDH-specific monoclonals and the screening of chemical compound libraries for PvLDH inhibitors.

Not Open Access | Endoplasmic Reticulum Stress Triggers Gametocytogenesis in the Malaria Parasite

June 18, 2014 - 15:45 -- NOT Open Access
Author(s): 
Shweta Chaubey, Manish Grover and Utpal Tatu
Reference: 
June 13, 2014 The Journal of Biological Chemistry, 289, 16662-16674.

The overall outcome was up-regulation of genes involved in protein export and the sexual stage of the parasite life cycle culminating in gametocytogenesis. Our results suggest that the malaria parasite uses ER stress as a cue to switch to the transmissible sexual stages.

Genome-Wide Analysis of Selection on the Malaria Parasite Plasmodium falciparum in West African Populations of Differing Infection Endemicity

May 26, 2014 - 18:55 -- Open Access
Author(s): 
Victor A. Mobegi, Craig W. Duffy, David J. Conway, et al.
Reference: 
Mol Biol Evol (2014) 31 (6): 1490-1499

Paired-end short-read sequences were mapped against the 3D7 P. falciparum reference genome sequence, and data on 136,144 single nucleotide polymorphisms (SNPs) were obtained. 

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Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?

January 17, 2014 - 19:03 -- Open Access
Author(s): 
Thales Kronenberger, Jasmin Lindner, Kamila A. Meissner, Flávia M. Zimbres, Monika A. Coronado, Frank M. Sauer, Isolmar Schettert, and Carsten Wrenger
Reference: 
BioMed Research International, Volume 2014 (2014)

It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets.

Ahead of the curve: next generation estimators of drug resistance in malaria infections

June 28, 2013 - 18:24 -- Open Access
Author(s): 
Nicole Mideo, David A. Kennedy, Jane M. Carlton, Jeffrey A. Bailey, Jonathan J. Juliano, Andrew F. Read
Reference: 
Trends in Parasitology, Volume 29, Issue 7, July 2013, Pages 321-328
MalariaWorld

A key challenge is detecting the early signs of drug resistance when little is known about its genetic basis. Focusing on malaria parasites, we propose a way to do this.

Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy

June 28, 2013 - 18:21 -- Open Access
Author(s): 
Sanjeev Krishna, Peter Gottfried Kremsner
Reference: 
Trends in Parasitology, Volume 29, Issue 7, July 2013, Pages 313-317
MalariaWorld

This opinion article reviews the mechanisms underlying parasite clearance after artemisinin treatment and how these might relate to in vitro methods to assay for resistance.

Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children

January 13, 2013 - 13:44 -- Open Access
Author(s): 
Koukouikila-Koussounda F, Ntoumi F, Ndounga M, Tong HV, Abena A, Velavan TP
Reference: 
Malaria Journal 2013, 12:9 (8 January 2013)
MalariaWorld

The study indicated that the STAT6 promoter polymorphism rs3024944 was associated with uncomplicated malaria, whereas the FOXP3 promoter variant rs11091253 was associated with significant P. falciparum parasitaemia levels.

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