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Brazil

Evaluation of prediction models for the occurrence of malaria in the state of Amapa, Brazil, 1997-2016: an ecological study

February 25, 2021 - 10:21 -- Open Access
Author(s): 
Lima MVM, Laporta GZ
Reference: 
Epidemiol Serv Saude. 2021 Feb 15;30(1):e2020080

To evaluate the predictive power of different malaria case time-series models in the state of Amapá, Brazil, for the period 1997-2016.

The top 1%: quantifying the unequal distribution of malaria in Brazil

February 15, 2021 - 16:03 -- Open Access
Author(s): 
Raquel Lana, Narimane Nekkab, Andre M. Siqueira, Cassio Peterka, Paola Marchesini, Marcus Lacerda, Ivo Mueller, Michael White and Daniel Villela
Reference: 
Malaria Journal 2021 20:87, 12 February 2021

As malaria endemic countries strive towards elimination, intensified spatial heterogeneities of local transmission could undermine the effectiveness of traditional intervention policy.

Value regimes and pricing in the pharmaceutical industry: financial capital inflation (hepatitis C) versus innovation and production capital savings for malaria medicines

January 21, 2021 - 15:22 -- Open Access
Author(s): 
Cassier M
Reference: 
Biosocieties. 2021 Jan 13:1-19

The idea of this paper is to draw a parallel between two diametrically opposed political economies of medicine that coexist today. The first is embodied in the invention, appropriation, and distribution of antivirals for hepatitis C, particularly sofosbuvir, which was commercialized at an initial price of $85,000 in the United States, €56,000 in France, and $8000 in Brazil.

Measuring the contribution of human mobility to malaria persistence

November 12, 2020 - 15:51 -- Open Access
Author(s): 
Marcelo F. C. Gomes, Cláudia T Codeço, Leonardo S. Bastos and Raquel M. Lana
Reference: 
Malaria Journal 2020 19:404, 11 November 2020

To achieve malaria elimination, it is important to determine the role of human mobility in parasite transmission maintenance. The Alto Juruá basin (Brazil) exhibits one of the largest vivax and falciparum malaria prevalence in the Amazon. The goal of this study was to estimate the contribution of human commutes to malaria persistence in this region, using data from an origin-destination survey.

Population genomics reveals the expansion of highly inbred Plasmodium vivax lineages in the main malaria hotspot of Brazil

October 31, 2020 - 09:50 -- Open Access
Author(s): 
de Oliveira TC, Corder RM, Early A, Rodrigues PT, Ladeia-Andrade S, Alves JMP, Neafsey DE, Ferreira MU
Reference: 
PLoS Negl Trop Dis. 2020 Oct 28;14(10):e0008808

Plasmodium vivax is a neglected human malaria parasite that causes significant morbidity in the Americas, the Middle East, Asia, and the Western Pacific. Population genomic approaches remain little explored to map local and regional transmission pathways of P. vivax across the main endemic sites in the Americas, where great progress has been made towards malaria elimination over the past decades.

Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies

October 31, 2020 - 09:35 -- Open Access
Author(s): 
Rocha EM, Katak RM, Campos de Oliveira J, Araujo MDS, Carlos BC, Galizi R, Tripet F, Marinotti O, Souza-Neto JA
Reference: 
Trop Med Infect Dis. 2020 Oct 20;5(4):E161

In Brazil, malaria transmission is mostly confined to the Amazon, where substantial progress has been made towards disease control in the past decade. Vector control has been historically considered a fundamental part of the main malaria control programs implemented in Brazil. However, the conventional vector-control tools have been insufficient to control or eliminate local vector populations due to the complexity of the Amazonian rainforest environment and ecological features of malaria vector species in the Amazon, especially Anopheles darlingi.

The influence of anthropogenic habitat fragmentation on the genetic structure and diversity of the malaria vector Anopheles cruzii (Diptera: Culicidae)

October 28, 2020 - 08:40 -- Open Access
Author(s): 
Multini LC, de Souza ALDS, Marrelli MT, Wilke ABB
Reference: 
Sci Rep. 2020 Oct 22;10(1):18018

Fragmentation of natural environments as a result of human interference has been associated with a decrease in species richness and increase in abundance of a few species that have adapted to these environments. The Brazilian Atlantic Forest, which has been undergoing an intense process of fragmentation and deforestation caused by human-made changes to the environment, is an important hotspot for malaria transmission.

Not Open Access | Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients

October 1, 2020 - 15:46 -- NOT Open Access
Author(s): 
Almeida AC, Elias ABR, Marques MP, de Melo GC, da Costa AG, Figueiredo EFG, Brasil LW, Rodrigues-Soares F, Monteiro WM, de Lacerda MVG, Lanchote VL, Suarez-Kurtz G
Reference: 
Br J Clin Pharmacol. 2020 Sep 30

To investigate the impact of Plasmodium vivax malaria and chloroquine‐primaquine chemotherapy on CYP2D6 and CYP2C19 activity in patients from the Brazilian Amazon.

Changes in malaria patterns in Brazil over 28 years (1990-2017): results from the Global Burden of Disease Study 2017

October 1, 2020 - 15:34 -- Open Access
Author(s): 
Bezerra JMT, Barbosa DS, Martins-Melo FR, Werneck GL, Braga ÉM, Tauil PL, Carneiro M
Reference: 
Popul Health Metr. 2020 Sep 30;18(Suppl 1):5

This study presents the malaria burden in Brazil from 1990 to 2017 using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), by analyzing disease burden indicators in federated units of the Legal Amazon and Extra-Amazon regions, as well as describing malaria cases according to Plasmodium species occurring in the country.

Contributing to Elimination of Cross-Border Malaria Through a Standardized Solution for Case Surveillance, Data Sharing, and Data Interpretation: Development of a Cross-Border Monitoring System

September 5, 2020 - 15:55 -- Open Access
Author(s): 
Saldanha R, Mosnier É, Barcellos C, Carbunar A, Charron C, Desconnets JC, Guarmit B, Gomes MDSM, Mandon T, Mendes AM, Peiter PC, Musset L, Sanna A, Van Gastel B, Roux E
Reference: 
JMIR Public Health Surveill. 2020 Sep 1;6(3):e15409

Cross-border malaria is a significant obstacle to achieving malaria control and elimination worldwide.

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