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Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China

May 6, 2021 - 07:19 -- Open Access
Weijia Cheng, Xiaonan Song, Huabing Tan, Kai Wu and Jian Li
Malaria Journal 2021 20:209, 1 May 2021

Imported malaria parasites with anti-malarial drug resistance (ADR) from Africa is a serious public health challenge in non-malarial regions, including Wuhan, China. It is crucial to assess the ADR status in African Plasmodium falciparum isolates from imported malaria cases, as this will provide valuable information for rational medication and malaria control.

NOT Open Access | Characterization of pfmdr1, pfcrt, pfK13, pfubp1, and pfap2mu in travelers returning from Africa with Plasmodium falciparum infections reported in China from 2014-2018

April 29, 2021 - 07:24 -- NOT Open Access
Feng J, Xu D, Kong X, Lin K, Yan H, Feng X, Tu H, Xia Z
Antimicrob Agents Chemother. 2021 Apr 26:AAC.02717-20

The artemisinin-based combination therapies (ACTs) used to treat Plasmodium falciparum in Africa are threatened by the emergence of parasites in Asia carrying variants of the Kelch 13 (K13) locus with delayed clearance in response to ACTs. Single nucleotide polymorphisms (SNPs) in other molecular markers, such as ap2mu and ubp1, were associated with artemisinin resistance in rodent malaria and clinical failure in African malaria patients. Here, we characterized the polymorphisms in pfmdr1, pfcrt, pfK13, pfubp1 and pfap2mu among African isolates reported in Shandong and Guangxi provinces in China.

From malaria elimination to post‐elimination: a 10-year surveillance data study in Shanghai

April 28, 2021 - 15:48 -- Open Access
Simin Dai, Min Zhu, Huanyu Wu, Yaoguang Zhang, Zhenyu Wang, Chengang Zhang, Xiaojiang Ma and Li Jiang
Malaria Journal 2021 20:199, 26 April 2021

The aim of this study was to investigate and analyse the characteristics of malaria in Shanghai from 2010 to 2019 and to provide suggestions for areas with a similar elimination process in China in order to prompt development of strategies and interventions in the post-elimination stage.

From 30 million to zero malaria cases in China: lessons learned for China-Africa collaboration in malaria elimination

April 22, 2021 - 08:27 -- Open Access
Chen JH, Fen J, Zhou XN
Infect Dis Poverty. 2021 Apr 20;10(1):51

Malaria was once one of the most serious public health problems in China, with more than 30 million malaria cases annually before 1949. However, the disease burden has sharply declined and the epidemic areas has shrunken after the implementation of an integrated malaria control and elimination strategy, especially since 2000.

Using Hawkes Processes to model imported and local malaria cases in near-elimination settings

April 6, 2021 - 13:57 -- Open Access
Unwin HJT, Routledge I, Flaxman S, Rizoiu MA, Lai S, Cohen J, Weiss DJ, Mishra S, Bhatt S
PLoS Comput Biol. 2021 Apr 1;17(4):e1008830.

Developing new methods for modelling infectious diseases outbreaks is important for monitoring transmission and developing policy. In this paper we propose using semi-mechanistic Hawkes Processes for modelling malaria transmission in near-elimination settings. Hawkes Processes are well founded mathematical methods that enable us to combine the benefits of both statistical and mechanistic models to recreate and forecast disease transmission beyond just malaria outbreak scenarios.

The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China

March 24, 2021 - 14:40 -- Open Access
Herong Huang, Ying Dong, Yanchun Xu, Yan Deng, Canglin Zhang, Shuping Liu, Mengni Chen and Yan Liu
Malaria Journal 2021 20:160, 20 March 2021

Accumulating evidence suggest that compromised CYP2D6 enzyme activity caused by gene mutation could contribute to primaquine failure for the radical cure of vivax malaria. The current study aims to preliminarily reveal the association between the recurrence of vivax malaria in Yunnan Province and CYP2D6 gene mutation by analysing polymorphisms in the entire coding region of human CYP2D6 gene.

Research supporting malaria control and elimination in China over four decades: a bibliometric analysis of academic articles published in chinese from 1980 to 2019

March 24, 2021 - 14:31 -- Open Access
Yan-Qiu Du, Guo-Ding Zhu, Jun Cao and Jia-Yan Huang
Malaria Journal 2021 20:158, 20 March 2021

China has accumulated considerable experience in malaria control and elimination over the past decades. Many research papers have been published in Chinese journals. This study intends to describe the development and experience of malaria control and elimination in China by quantitatively analysing relevant research using a bibliometric analysis.

A survey of insecticide resistance-conferring mutations in multiple targets in Anopheles sinensis populations across Sichuan, China

March 23, 2021 - 14:50 -- Open Access
Qian W, Liu N, Yang Y, Liu J, He J, Chen Z, Li M, Qiu X
Parasit Vectors. 2021 Mar 20;14(1):169

Sichuan province is located in the southwest of China, and was previously a malaria-endemic region. Although no indigenous malaria case has been reported since 2011, the number of imported cases is on the rise. Insecticide-based vector control has played a central role in the prevention of malaria epidemics. However, the efficacy of this strategy is gravely challenged by the development of insecticide resistance. Regular monitoring of insecticide resistance is essential to inform evidence-based vector control. Unfortunately, almost no information is currently available on the status of insecticide resistance and associated mechanisms in Anopheles sinensis, the dominant malaria vector in Sichuan. In this study, efforts were invested in detecting the presence and frequency of insecticide resistance-associated mutations in three genes that encode target proteins of several classes of commonly used insecticides.

Seven decades towards malaria elimination in Yunnan, China

March 18, 2021 - 09:16 -- Open Access
Xiao-Hong Li, Hong-Ning Zhou, Jian-Wei Xu, Zu-Rui Lin, Xiao-Dong Sun, Jia-Yin Li, Xian-Xian Lin, Yan Xie, Pedro Alonso and Heng-Lin Yang
Malaria Journal 2021 20:147, 12 March 2021

Yunnan Province was considered the most difficult place in China for malaria elimination because of its complex malaria epidemiology, heterogeneous ecological features, relatively modest economic development, and long, porous border with three malaria endemic countries: Lao People’s Democratic Republic, Myanmar, and Viet Nam.

NOT Open Access | In Vitro Susceptibility of Plasmodium falciparum Isolates from the China-Myanmar Border Area to Piperaquine and Association with Candidate Markers

March 13, 2021 - 16:31 -- NOT Open Access
Si Y, Zeng W, Cui L, et al.
Antimicrob Agents Chemother. 2021 Mar 8:AAC.02305-20

Plasmodium falciparum from the Greater Mekong subregion has evolved resistance to the artemisinin-based combination therapy dihydroartemisinin and the partner drug piperaquine. To monitor the potential westward spread or independent evolution of piperaquine resistance, we evaluated the in vitro susceptibility of 120 P. falciparum isolates collected at the China-Myanmar border during 2007-2016.


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