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China

Epidemiological characterization of imported recurrent Plasmodium vivax and Plasmodium ovale in China, 2013-2020

August 25, 2021 - 16:59 -- Open Access
Author(s): 
Cui Y, Zhang L, Xia Z, Zhou H, Huang F
Reference: 
Infect Dis Poverty. 2021 Aug 23;10(1):113

China has reached important milestones in the elimination of malaria. However, the numbers of imported recurrent cases of Plasmodium vivax and P. ovale are gradually increasing, which increases the risk of malaria re-establishment in locations where Anopheles mosquitoes exist. The aim of this study is to characterize the epidemiological profiles of imported recurrent P. vivax and P. ovale cases, quantifying the recurrence burden and guiding the development of appropriate public health intervention strategies.

Limited polymorphism in k13 gene of Plasmodium falciparum and k12 of Plasmodium vivax isolates imported from African and Asian countries between 2014 and 2019 in Hangzhou city, China

August 25, 2021 - 16:57 -- Open Access
Author(s): 
Jin X, Zhu S, Xu W, Chen J, Ruan W, Wang X
Reference: 
BMC Infect Dis. 2021 Aug 21;21(1):853

Malaria causes major public health problems globally and drug resistance hinders its control and elimination. Molecular markers associated with drug resistance are considered as a beneficial tool to monitor the disease trends, evolution and distribution so as to help improve drug policy.

Malaria: elimination tale from Yunnan Province of China and new challenges for reintroduction

July 28, 2021 - 13:57 -- Open Access
Author(s): 
Yang HL, Baloch Z, Zhou HN, et al.
Reference: 
Infect Dis Poverty. 2021 Jul 21;10(1):101

Eradication of infectious disease is the sanctified public health and sustainable development goal around the world.

The mechanisms of action of Plasmodium infection against cancer

July 14, 2021 - 10:30 -- Open Access
Author(s): 
Chen X, Qin L, Hu W, Adah D
Reference: 
Cell Commun Signal. 2021 Jul 9;19(1):74

Our murine cancer model studies have demonstrated that Plasmodium infection activates the immune system that has been inhibited by cancer cells, counteracts tumor immunosuppressive microenvironment, inhibits tumor angiogenesis, inhibits tumor growth and metastasis, and prolongs the survival time of tumor-bearing mice. Based on these studies, three clinical trials of Plasmodium immunotherapy for advanced cancers have been approved and are ongoing in China.

NOT Open Access | Evaluation of the combination of rapid diagnostic tests and microscopy for imported malaria surveillance in Anhui Province, China

July 14, 2021 - 10:18 -- NOT Open Access
Author(s): 
Li W, Zhang X, Feng J, Zhang T, Xu X, Jiang J, Wang S, Lyu X, Li S, Lu M
Reference: 
Acta Trop. 2021 Jul 9:106042

In the Anhui Province, China, efforts to interrupt the local malaria transmission were successful, with no endemic cases reported since 2014. Contrastingly, imported malaria cases are still being reported, indicating a disease reintroduction risk after years of elimination. A good surveillance system is key for avoiding the risk, detecting imported cases and possible cases associated with local transmission early. Therefore, rapid diagnostic tests (RDTs) were combined with microscopy to strengthen malaria surveillance in the province. Herein, we aimed to evaluate the efficacy of this surveillance strategy.

China declared malaria-free: a milestone in the world malaria eradication and Chinese public health

July 14, 2021 - 09:59 -- Open Access
Tags: 
Author(s): 
Zhou XN
Reference: 
Infect Dis Poverty. 2021 Jul 12;10(1):98

On 30 June 2021, the World Health Organization announced that the People’s Republic of China (PR China) had been certified malaria-free, after a field mission in PR China in May 2021 by an independent certification panel. This award of malaria-free certification is a major milestone both for the world history in malaria eradication programme and for the Chinese public health history.

NOT Open Access | Increasing proportions of relapsing parasite species among imported malaria in China's Guangxi Province from Western and Central Africa

June 30, 2021 - 13:01 -- NOT Open Access
Author(s): 
Liu P, Shen L, Yang Z, et al.
Reference: 
Travel Med Infect Dis. 2021 Jun 21;43:102130

Travel-related malaria in non-endemic areas returning from endemic areas presents important challenges to diagnosis and treatment. Imported malaria to newly malaria-free countries poses further threats of malaria re-introduction and potential resurgence. For those traveling to places with high Plasmodium falciparum prevalence, prophylaxis against this parasite is recommended, whereas causal prophylaxis against relapsing malaria is often overlooked.

SARS-CoV-2 and Plasmodium falciparum are probably adopting Analogous strategy to invade erythrocytes

June 15, 2021 - 15:14 -- Open Access
Author(s): 
Konozy EHE, Osman MEM, Iesa MAM
Reference: 
J Infect Public Health. 2021 Jun 9;14(7):883-885

The highly contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which causes COVID-19 started at the end of 2019 in Wuhan city in China from where it stretched to the entire globe affecting different nations in different manners. Though this virus showed high potential to spread more quickly in certain territories within a short period of a few months.

Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China

May 6, 2021 - 07:19 -- Open Access
Author(s): 
Weijia Cheng, Xiaonan Song, Huabing Tan, Kai Wu and Jian Li
Reference: 
Malaria Journal 2021 20:209, 1 May 2021

Imported malaria parasites with anti-malarial drug resistance (ADR) from Africa is a serious public health challenge in non-malarial regions, including Wuhan, China. It is crucial to assess the ADR status in African Plasmodium falciparum isolates from imported malaria cases, as this will provide valuable information for rational medication and malaria control.

NOT Open Access | Characterization of pfmdr1, pfcrt, pfK13, pfubp1, and pfap2mu in travelers returning from Africa with Plasmodium falciparum infections reported in China from 2014-2018

April 29, 2021 - 07:24 -- NOT Open Access
Author(s): 
Feng J, Xu D, Kong X, Lin K, Yan H, Feng X, Tu H, Xia Z
Reference: 
Antimicrob Agents Chemother. 2021 Apr 26:AAC.02717-20

The artemisinin-based combination therapies (ACTs) used to treat Plasmodium falciparum in Africa are threatened by the emergence of parasites in Asia carrying variants of the Kelch 13 (K13) locus with delayed clearance in response to ACTs. Single nucleotide polymorphisms (SNPs) in other molecular markers, such as ap2mu and ubp1, were associated with artemisinin resistance in rodent malaria and clinical failure in African malaria patients. Here, we characterized the polymorphisms in pfmdr1, pfcrt, pfK13, pfubp1 and pfap2mu among African isolates reported in Shandong and Guangxi provinces in China.

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