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NOT Open Access | ASDB: A comprehensive omics database for Anopheles sinensis

February 16, 2021 - 15:41 -- NOT Open Access
Zhang YJ, Lan Y, Chen B
Genomics. 2021 Feb 12:S0888-7543(21)00056-2

Anopheles sinensis is a key disease vector for human malaria and parasitic diseases such as malayan filariasis, and it is considered to be one of the most important malaria vectors in China and Southeast Asia. As high-throughput sequencing and assembly technology are widely used in An. sinensis, a lot of omics data have been generated, and abundant genome, mRNA transcriptome, miRNA transcriptome and resequencing results have been accumulated.

Epidemiological profile of Plasmodium ovale spp. imported from Africa to Anhui Province, China, 2012–2019

January 9, 2021 - 12:22 -- Open Access
Tao Zhang, Shuqi Wang, Weidong Li, et al.
Malaria Journal 2021 20:15, 6 January 2021

Although autochthonous malaria cases are no longer reported in Anhui Province, China, imported malaria has become a major health concern. The proportion of reported malaria cases caused by Plasmodium ovale spp. increased to levels higher than expected during 2012 to 2019, and showed two peaks, 19.69% in 2015 and 19.35% in 2018.

Transition of radical, preventive and presumptive treatment regimens for malaria in China: a systematic review

January 7, 2021 - 12:04 -- Open Access
Jian-Wei Xu, Rogan Lee, Xiao-Hong Li and Hui Liu
Malaria Journal 2021 20:10, 6 January 2021

Globally, malaria is still a major public health challenge. Drug-based treatment is the primary intervention in malaria control and elimination. However, optimal use of mass or targeted treatments remains unclear. A variety of radical, preventive and presumptive treatment regimens have been administrated in China and a systematic review was conducted to evaluate effectiveness, and discuss experiences, limitations, and lessons learnt in relation to the use of these regimens.

NOT Open Access | Effect of temperature and its interactions with relative humidity and rainfall on malaria in a temperate city Suzhou, China

January 5, 2021 - 15:50 -- NOT Open Access
Liu Z, Wang S, Zhang Y, Xiang J, Tong MX, Gao Q, Zhang Y, Sun S, Liu Q, Jiang B, Bi P
Environ Sci Pollut Res Int. 2021 Jan 4

Malaria is a climate-sensitive infectious disease. Many ecological studies have investigated the independent impacts of ambient temperature on malaria. However, the optimal temperature measures of malaria and its interaction with other meteorological factors on malaria transmission are less understood. This study aims to investigate the effect of ambient temperature and its interactions with relative humidity and rainfall on malaria in Suzhou, a temperate climate city in Anhui Province, China. Weekly malaria and meteorological data from 2005 to 2012 were obtained for Suzhou.

Molecular surveillance of anti-malarial resistance Pfdhfr and Pfdhps polymorphisms in African and Southeast Asia Plasmodium falciparum imported parasites to Wuhan, China

November 28, 2020 - 16:22 -- Open Access
Tingting Jiang, Weijia Cheng, Yi Yao, Huabing Tan, Kai Wu and Jian Li
Malaria Journal 2020 19:434, 25 November 2020

Anti-malarial drug resistance is a severe challenge for eventual control and global elimination of malaria. Resistance to sulfadoxine-pyrimethamine (SP) increases as mutations accumulate in the Pfdhfr and Pfdhps genes. This study aimed to assess the polymorphisms and prevalence of mutation in these genes in the Plasmodium falciparum infecting migrant workers returning to Wuhan, China.

From control to elimination: a spatial-temporal analysis of malaria along the China-Myanmar border

November 25, 2020 - 12:01 -- Open Access
Huang F, Zhang L, Xue JB, Zhou HN, Thi A, Zhang J, Zhou SS, Xia ZG, Zhou XN
Infect Dis Poverty. 2020 Nov 19;9(1):158

Malaria cases have declined significantly along the China-Myanmar border in the past 10 years and this region is going through a process from control to elimination. The aim of this study is to investigate the epidemiology of malaria along the border, will identify challenges in the progress from control to elimination.

Analysis of initial laboratory diagnosis of malaria and its accuracy compared with re-testing from 2013 to 2018 in Yunnan Province, China

November 14, 2020 - 16:02 -- Open Access
Ying Dong, Yan Deng, Yanchun Xu, Mengni Chen, Chun Wei, Canglin Zhang, Xianghua Mao and Jingbo Xue
Malaria Journal 2020 19:409, 12 November 2020

According to China’s Malaria Eradication Action Plan, malaria cases diagnosed and reported by health authorities at the county level must be further re-confirmed by provincial laboratories. The Yunnan Province Malaria Diagnostic Reference Laboratory (YPMDRL) began the synchronous implementation of microscopic examinations and nested polymerase chain reaction (nested-PCR) testing to re-test the malaria cases initially diagnosed by county-level laboratories and to evaluate the consistency of Plasmodium species identified between by YPMDRL and by the county-level laboratories from 2013 to 2018 in Yunnan Province.

Epidemiology, evolutionary origin, and malaria-induced positive selection effects of G6PD-deficient alleles in Chinese populations

November 4, 2020 - 10:30 -- Open Access
Zheng Y, Wang J, Lin M, et al.
Mol Genet Genomic Med. 2020 Oct 31:e1540

Although glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is the most common inherited disorder in the Chinese population, there is scarce evidence regarding the epidemiology, evolutionary origin, and malaria‐induced positive selection effects of G6PD‐deficient alleles in various Chinese ethnic populations.

Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma model

September 29, 2020 - 13:12 -- Open Access
Wang B, Li Q, Wang J, Zhao S, Nashun B, Qin L, Chen X
Cell Commun Signal. 2020 Sep 24; 18 (1):157

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in China. The lack of an effective treatment for this disease results in a high recurrence rate in patients who undergo radical tumor resection, and the 5-year survival rate of these patients remains low. Our previous studies demonstrated that Plasmodium infection provides a potent antitumor effect by inducing innate and adaptive immunity in a murine Lewis lung carcinoma (LLC) model.

Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives

September 24, 2020 - 14:05 -- Open Access
Zhang XL, Li ZM, Ye JT, Lu J, Ye LL, Zhang CX, Liu PQ, Duan DD
Acta Pharmacol Sin. 2020 Sep 23

The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients.


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