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vivax malaria

New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring

April 27, 2020 - 14:10 -- Open Access
Author(s): 
Alves-Junior ER, Gomes LT, Dombroski TCD, Nery AF, Filho SV, Nakazato L, Fontes CJF, Rios-Santos F
Reference: 
Braz J Infect Dis. 2020 Apr 23. pii: S1413-8670(20)30027-1

In recent years, the number of cases with severe Plasmodium vivax malaria has shown an increasing trend. It is, therefore, important to identify routine laboratory markers that best characterize the acute disease phase and can serve as a tool for clinical follow-up of patients. In a cohort study, we followed 87 patients with acute P. vivax monoinfection acquired in an endemic region of the Brazilian Amazon. Forty-two different biochemical and hematological parameters frequently tested in clinical routine were evaluated at the acute phase and the convalescent phase.

NOT Open Access | Main B‐cell epitopes of PvAMA‐1 and PvMSP‐9 are targeted by naturally acquired antibodies and epitope‐specific memory cells in acute and convalescent phases of vivax malaria

April 20, 2020 - 08:54 -- NOT Open Access
Author(s): 
Roberta Reis Soares, Clovis Ryuichi Nakaie, Rodrigo Nunes Rodrigues‐da‐Silva, Rogério Lauria da Silva, Josué da Costa Lima‐Junior, Kézia Katiani Gorza Scopel
Reference: 
Parasite Immunology, Volume42, Issue5, May 2020 e12705

Although antibodies are considered critical for malaria protection, little is known about the mechanisms/factors that maintain humoral immunity, especially regarding the induction and maintenance of memory B cells over time. In Brazilian endemic areas, this is the first time that the profile of antibody responses and the occurrence of antigen‐specific memory B cells (MBC) against P vivax were investigated during acute malaria and up to six months after parasite clearance.

NOT Open Access | Main B-cell epitopes of PvAMA-1 and PvMSP-9 are targeted by naturally acquired antibodies and epitope-specific memory cells in acute and convalescent phases of vivax malaria

March 2, 2020 - 15:13 -- NOT Open Access
Author(s): 
Soares RR, Nakaie CR, Rodrigues-da-Silva RN, da Silva RL, da Costa Lima-Junior J, Scopel KKG
Reference: 
Parasite Immunol. 2020 Feb 24:e12705

Although antibodies are considered critical for malaria protection, little is known about the mechanisms/factors that maintain humoral immunity, especially regarding the induction and maintenance of memory B cells over time. In Brazilian endemic areas, this is the first time that the profile of antibody responses and the occurrence of antigen‐specific memory B‐cells (MBC) against P. vivax were investigated during acute malaria and up to six months after parasite clearance.

Singultus as an Unusual Debut of Plasmodium vivax Malaria

November 19, 2019 - 15:14 -- Open Access
Author(s): 
Guadarrama-Conzuelo F, Saad Manzanera AD.
Reference: 
Cureus. 2019 Sep 1;11(9):e5548.

We describe this previously unreported association, hypothesize on the potential mechanism and review the literature on singultus and unusual presentations of Plasmodium infections.

Misperceptions of patients and health workers regarding malaria elimination in the Brazilian Amazon: a qualitative study

July 8, 2019 - 16:58 -- Open Access
Author(s): 
Felipe Leão Gomes Murta, Maxwell Oliveira Mendes, Vanderson Souza Sampaio, Abrahim Sena Baze Junior, Ximena Pamela Díaz-Bermúdez, Wuelton Marcelo Monteiro and Marcus Vinícius Guimarães Lacerda
Reference: 
Malaria Journal 2019 18:223, 4 July 2019

Brazil has considerably reduced the number of cases of malaria in recent years and aims to eradicate the disease completely, however, vivax malaria continues to be a major challenge for the health system. In this context, the key to building a successful elimination programme may lie in the knowledge and the perceptions of the health agents, the patients affected by the disease and the personnel responsible for malaria diagnosis, treatment and control at the local level.

Factors associated with children’s health facility visits for primaquine treatment in rural Papua New Guinea

February 21, 2019 - 16:30 -- Open Access
Author(s): 
Akiko Yoshii, Makoto Sekihara, Takuro Furusawa, Francis Hombhanje and Takahiro Tsukahara
Reference: 
Malaria Journal 2019 18:42, 20 February 2019

Few children received PQ treatment during the second visit to HFs following diagnosis of potential non-falciparum malaria.

Medical Treatment: 

G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients

November 15, 2018 - 15:00 -- Open Access
Author(s): 
Sara Avalos, Rosa E. Mejia, Gustavo Fontecha, et al.
Reference: 
Malaria Journal 2018 17:415

The findings support that the intake of PQ during 14 days of treatment against vivax malaria is safe in patients with a class III variant of G6PDd. In view of the new national regulations in the shortened treatment of vivax malaria for 7 days, it is advisable to be alert of potential cases of severe haemolysis that could occur among G6PD deficient hemizygous males with a class II mutation such as the Santamaria variant, previously reported in the country.

Diversity pattern of Duffy binding protein sequence among Duffy-negatives and Duffy-positives in Sudan

August 21, 2018 - 14:34 -- Open Access
Author(s): 
Mohammad Rafiul Hoque, Mohammed Mohieldien Abbas Elfaki, Md Atique Ahmed, Seong-Kyun Lee, Fauzi Muh, Musab M. Ali Albsheer, Muzamil Mahdi Abdel Hamid and Eun-Taek Han
Reference: 
Malaria Journal 2018 17:297, 17 August 2018

This is the first pvdbp genetic diversity study from an African country. Sudanese isolates display high haplotype diversity and the gene is under selective pressure.

Country: 

Malaria control and chemoprophylaxis policy in the Republic of Korea Armed Forces for the previous 20 years (1997–2016)

August 15, 2018 - 16:33 -- Open Access
Author(s): 
Jae Hyoung Im, Kyungmin Huh, Chang-Gyo Yoon, Hyeongtaek Woo, Jin-Soo Lee, Moon-Hyun Chung, Terry A. Klein and Jaehun Jung
Reference: 
Malaria Journal 2018 17:295, 15 August 2018

The resurgence of vivax malaria in the ROK Armed Forces personnel near the DMZ was successfully suppressed through the implementation of a mass malaria chemoprophylaxis programme initiated by the MND in 1997, as well as several other factors that may have contributed to the reduction of malaria transmission since 2000.

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