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falciparum malaria

Ethics, Economics, and the Use of Primaquine to Reduce Falciparum Malaria Transmission in Asymptomatic Populations

August 25, 2014 - 09:53 -- Open Access
Author(s): 
Yoel Lubell, Lisa White, Sheila Varadan, Tom Drake, Shunmay Yeung, Phaik Yeong Cheah, Richard J. Maude, Arjen Dondorp, Nicholas P. J. Day, Nicholas J. White, Michael Parker
Reference: 
PLoS Med 11(8): e1001704

Following a decade of gains in malaria control, two divergent prospects are emerging:

Medical Treatment: 

IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women

August 20, 2014 - 06:27 -- Open Access
Author(s): 
Nasr A, Allam G, Hamid O, Al-Ghamdi A
Reference: 
Malaria Journal 2014, 13 :314 (13 August 2014)

This data provides a starting point for functional and genetic analysis of the TNF and IFN-γ genomic region in malaria infection affecting Saudi populations.

Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study

July 30, 2014 - 14:02 -- Open Access
Author(s): 
Li Q, Remich S, Miller SR, Ogutu B, Otieno W, Melendez V, Teja-Isavadharm P, Weina PJ, Hickman MR, Smith B, Polhemus M
Reference: 
Malaria Journal 2014, 13 :281 (22 July 2014)

Intravenous AS can provide much higher peak concentrations of AS when compared to concentrations achieved with oral therapy; this may be crucial for the rapid elimination of parasites in patients with severe malaria.

Person: 

Thiamin supplementation does not reduce the frequency of adverse events after anti-malarial therapy among patients with falciparum malaria in southern Laos

July 22, 2014 - 09:24 -- Open Access
Author(s): 
Mayxay M, Khanthavong M, Cox L, Sichanthongthip O, Imwong M, Pongvongsa T, Hongvanthong B, Phompida S, Vanisaveth V, White NJ, Newton PN
Reference: 
Malaria Journal 2014, 13 :275 (15 July 2014)

Thiamin supplementation reduced biochemical thiamin deficiency among Lao malaria patients following anti-malarial drug treatment, but it did not reduce the frequency of adverse events after anti-malarial therapy or have any detected clinical or parasitological impact.

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Not Open Access | Differential Prevalence of Transporter Polymorphisms in Symptomatic and Asymptomatic Falciparum Malaria Infections in Uganda

June 18, 2014 - 15:55 -- NOT Open Access
Author(s): 
Stephen Tukwasibwe, Levi Mugenyi, George W. Mbogo, Sheila Nankoberanyi, Catherine Maiteki-Sebuguzi, Moses L. Joloba, Samuel L. Nsobya, Sarah G. Staedke and Philip J. Rosenthal
Reference: 
J Infect Dis. (2014) 210 (1): 154-157.

We explored associations between Plasmodium falciparum drug resistance–mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design.

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Reduced ADAMTS13 activity is associated with an ADAMTS13 SNP, fever and microparticles in a malaria-like model

January 7, 2014 - 09:53 -- Open Access
Author(s): 
Kraisin S, Palasuwan A, Popruk S, Nantakomol D
Reference: 
Malaria Journal 2014, 13 :3 (3 January 2014)

Severe falciparum malaria (SM) remains a major cause of death in tropical countries. The reduced activity of ADAMTS13, increasing levels of ultra-large von Willebrand factor (ULVWF) in SM patients, are assumed as factors that intensify disease severity.

Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia

December 17, 2013 - 19:06 -- Open Access
Author(s): 
Richard J. Maude, Kamolrat Silamut, Arjen M. Dondorp, et al.
Reference: 
Clin Infect Dis. (2014) 58 (1): 11-21.

Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria.

The reliability of the physical examination to guide fluid therapy in adults with severe falciparum malaria: an observational study

October 18, 2013 - 16:02 -- Open Access
Author(s): 
Josh Hanson, Sophia WK Lam, Shamsul Alam, Rajyabardhan Pattnaik, Kishore C Mahanta, Mahatab Uddin Hasan, Sanjib Mohanty, Saroj Mishra, Sophie Cohen, Nicholas Day, Nicholas White, Arjen Dondorp
Reference: 
Malaria Journal 2013, 12:348 (1 October 2013)
MalariaWorld

Findings on physical examination correlate poorly with true volume status in adults with severe malaria and must be used with caution to guide fluid therapy.

Not Open Access | Increased Carboxyhemoglobin in Adult Falciparum Malaria is Associated With Disease Severity and Mortality

August 7, 2013 - 18:13 -- NOT Open Access
Author(s): 
Tsin W. Yeo, Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, Ric N. Price and Nicholas M. Anstey
Reference: 
J Infect Dis. (2013) 208 (5): 813-817.
MalariaWorld

Increased carboxyhemoglobin levels during severe malaria and sepsis may exacerbate organ dysfunction by reducing oxygen carriage and cautions against the use of adjunctive CO therapy, which was proposed on the basis of mouse models.

Person: 

Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria

June 24, 2013 - 15:24 -- Open Access
Author(s): 
Taylor WR, Widjaja H, Basri H, Tjitra E, Ohrt C, Taufik T, Baso S, Hoffman SL, Richie TL
Reference: 
Malaria Journal 2013, 12:209 (19 June 2013)
MalariaWorld

Haemoglobin recovery was related to baseline Hb. Vivax-infected malaria immune Papuans had persistently lower Hb concentrations compared to non-Papuans with limited malaria exposure. This haematological disadvantage remains unexplained.

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