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falciparum malaria

Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges

December 13, 2017 - 15:52 -- Open Access
Author(s): 
Makoto Saito, Mary Ellen Gilder, François Nosten, Rose McGready and Philippe J. Guérin
Reference: 
Malaria Journal 2017 16:488, 13 December 2017

Efficacy studies in pregnancy are not only limited in number but use varied methodological assessments. In five RCTs with comparable methodology, ABT resulted in higher efficacy than QBT in the second and third trimester of pregnancy.

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Therapeutic efficacy of artesunate - amiodaquine for treating uncomplicated falciparum malaria at Ghindae Zonal Referral Hospital, Eritrea

November 3, 2017 - 05:56 -- Open Access
Author(s): 
Abdu O. Mohammed, Seltene Tewolde, Dawit Estifanos, Yohannes Tekeste, Mohammed-hamid Osman
Reference: 
Acta Tropica Volume 177, January 2018, Pages 94-96

Therapeutic efficacy of AS + AQ still meets the WHO efficacy criteria for its continued use in the study area as the first-line drug against uncomplicated falciparum malaria.

NOT Open Access | RANTES levels as a determinant of falciparum malaria severity or recovery

August 23, 2017 - 16:02 -- NOT Open Access
Author(s): 
D. Bujarbaruah, M. P. Kalita, V. Baruah, T. K. Basumatary, S. Hazarika, R. H. Begum, S. Medhi and S. Bose
Reference: 
Parasite Immunology, Volume 39, Issue 9 September 2017, e12452

The study explored the role of differential RANTES concentrations, its receptor CCR5 expression and resulting immunomodulation in the pathogenesis and/or recovery from falciparum malaria.

Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women

July 5, 2017 - 14:21 -- Open Access
Author(s): 
Ritah F. Mutagonda, Appolinary A. R. Kamuhabwa, Omary M. S. Minzi, Siriel N. Massawe, Muhammad Asghar, Manijeh V. Homann, Anna Färnert and Eleni Aklillu
Reference: 
Malaria Journal 2017 16:267, 3 July 2017

Genetic variations in CYP3A4 and CYP3A5may influence LF pharmacokinetics and treatment outcome in pregnant women.

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NOT Open Access | Efficacy and safety of artemether–lumefantrine for the treatment of uncomplicated falciparum malaria at sentinel sites in Mozambique, 2015

June 20, 2017 - 14:36 -- NOT Open Access
Author(s): 
Crizolgo Salvador, Bernardete Rafael, Sónia Enosse, et al.
Reference: 
Acta Tropica, Volume 171, July 2017, Pages 146–150

The resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control.

Medical Treatment: 

Molecular surveillance of artemisinin resistance falciparum malaria among migrant goldmine workers in Myanmar

March 9, 2017 - 14:45 -- Open Access
Author(s): 
Myat Htut Nyunt, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Jin-Hee Han, Seong-Kyun Lee, Kay Thwe Han, Ye Htut and Eun-Taek Han
Reference: 
Malaria Journal 2017 16:97, 1 March 2017

High mutant rate of artemisinin resistance markers and relatively high pfmdr1 copy number among isolates collected from migrant goldmine workers alert the importance of containment measures among this target population.

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The role of early detection and treatment in malaria elimination

July 19, 2016 - 16:20 -- Open Access
Author(s): 
Jordi Landier, Daniel M. Parker, François H. Nosten, et al.
Reference: 
Malaria Journal 2016 15:363, 15 July 2016

Falciparum malaria persists in hard-to-reach areas or demographic groups that are missed by conventional healthcare systems but could be reached by trained community members in a malaria post (MP).

NOT Open Access | Tumour necrosis factor alpha promoter polymorphism, TNF-238 is associated with severe clinical outcome of falciparum malaria in Ibadan southwest Nigeria

July 2, 2016 - 16:27 -- NOT Open Access
Author(s): 
Subulade A. Olaniyan, Olukemi K. Amodu, Adekunle A. Bakare, Marita Troye-Blomberg, Olayemi O. Omotade, Kirk A. Rockett
Reference: 
Acta Tropica, Volume 161, September 2016, Pages 62–67

Tumour necrosis factor (TNF) – α has been shown to play an important role in the pathogenesis of falciparum malaria.

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Clinical illness and outcomes in Nigerian children with late-appearing anaemia after artemisinin-based combination treatments of uncomplicated falciparum malaria

June 8, 2016 - 15:59 -- Open Access
Author(s): 
Sowunmi A, Akano K, Ayede A, Ntadom G, Aderoyeje T, Adewoye E, Fatunmbi B
Reference: 
BMC Infectious Diseases 2016, 16:240 (1 June 2016)

This was an open label study with the main objectives of evaluating the clinical features, the risk factors for, the temporal changes in haematocrit and the outcomes of a LAA in malarious children treated with artesunate-amodiaquine (AA), artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DHP). 

Field evaluation of a PfHRP-2/pLDH rapid diagnostic test and light microscopy for diagnosis and screening of falciparum malaria during the peak seasonal transmission in an endemic area in Yemen

February 2, 2016 - 18:56 -- Open Access
Author(s): 
Lina M. Q. Alareqi, Mohammed A. K. Mahdy, Yee-Ling Lau, Mun-Yik Fong, Rashad Abdul-Ghani, Arwa A. Ali, Fei-Wen Cheong, Rehab Tawfek and Rohela Mahmud
Reference: 
Malaria Journal 2016 15:49, 28 January 2016

The PfHRP-2/pLDH RDT shows high sensitivity for the survey of falciparum malaria even for asymptomatic malaria cases.

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