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falciparum malaria

Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study

March 27, 2019 - 15:53 -- Open Access
Hugh W. Kingston, Aniruddha Ghose, Arjen M. Dondorp, et al.
Malaria Journal 2019 18:97, 25 March 2019

Reduced total oxygen delivery is not a major contributor to lactic acidosis in severe falciparum malaria.

NOT Open Access | Identification of potential whole blood MicroRNA biomarkers for the blood stage of adult imported falciparum malaria through integrated mRNA and miRNA expression profiling

November 28, 2018 - 15:25 -- NOT Open Access
Jing-jing Li, Min-jun Huang, Zhen Li, Wei Li, Fei Wang, Lei Wang, Xiao-li Li, Xiaoyan Zheng, Yang Zou
Biochemical and Biophysical Research Communications Volume 506, Issue 3, 30 November 2018, Pages 471-477

Correlating aberrant miRNA levels with imported malaria during the blood stage is required to better understand the in vivo biological and molecular processes that are involved in the response to Plasmodium falciparum infection and to find new biomarkers and diagnosis tools.

Identifying risk factors for the development of sepsis during adult severe malaria

July 31, 2018 - 15:32 -- Open Access
Tsi Njim, Arjen Dondorp, Mavuto Mukaka and Eric O. Ohuma
Malaria Journal 2018 17:278, 31 July 2018

The proposed model identifies patients with severe malaria at risk of developing clinical sepsis, potentially benefiting from antibiotic treatment in addition to anti-malarials.

Pharmacokinetics of mefloquine administered with artesunate in patients with uncomplicated falciparum malaria from the Brazilian Amazon basin

July 17, 2018 - 15:55 -- Open Access
Michelle V. D. Ferreira, José L. F. Vieira, Eduardo D. Almeida, Juan G. B. Rivera, Margarete S. M. Gomes and André M. de Siqueira
Malaria Journal 2018 17:268, 16 July 2018

The pharmacokinetic parameters of mefloquine determined in the study suggest an adequate exposure of parasite to mefloquine in the multiple oral dose regimen of the fixed dose combination of mefloquine and artesunate.

Effectiveness and safety of 3 and 5 day courses of artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in an area of emerging artemisinin resistance in Myanmar

July 15, 2018 - 16:52 -- Open Access
Kyaw Myo Tun, Atthanee Jeeyapant, Frank Smithuis, et al.
Malaria Journal 2018 17:258, 11 July 2018

Despite a high prevalence of k13 mutations, the current first-line treatment, AL, was still highly effective in this area of South-East Myanmar.

Medical Treatment: 

Resistance screening and trend analysis of imported falciparum malaria in NSW, Australia (2010 to 2016)

June 5, 2018 - 14:48 -- Open Access
Christiane Prosser, Wieland Meyer, John Ellis, Rogan Lee
PLoS ONE 13(5): e0197369

The C580Y finding from outside of the greater Mekong subregion supports the consensus to upscale molecular surveillance of artemisinin resistance outside of South East Asia.

Medical Condition: 

An automated haematology analyzer XN-30 distinguishes developmental stages of falciparum malaria parasite cultured in vitro

February 6, 2018 - 17:19 -- Open Access
Takahiro Tougan, Yuhgi Suzuki, Sawako Itagaki, Munehisa Izuka, Yuji Toya, Kinya Uchihashi and Toshihiro Horii
Malaria Journal 2018 17:59, 2 February 2018

The XN-30 analyzer allows the precise recognition and enumeration of total and each developmental stages of cultured falciparum parasites, and permits the sensitive and reproducible calculation of parasitaemia.

NOT Open Access | Evaluation of rapid PfHRP-2/pLDH-based tests in diagnosing microscopy-confirmed falciparum malaria in Hodeidah governorate, Yemen

January 2, 2018 - 15:02 -- NOT Open Access
Ahmed A. Azazy, Ali Jamaly Alhawery, Rashad Abdul-Ghani, R.A. Alharbi, Shaia S.R. Almalki
Acta Tropica Volume 178, February 2018, Pages 252–257

Along with the determination of malaria infection rate among suspected patients attending hospitals in Hodeidah governorate, the present study evaluated the accuracy of Plasmodium falciparum histidine-rich protein-2 (PfHRP-2)/parasite-specific lactate dehydrogenase (pLDH)-based rapid diagnostic test (RDT) for the diagnosis of microscopy-confirmed falciparum malaria.

Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review

December 19, 2017 - 15:24 -- Open Access
Makoto Saito, Mary Ellen Gilder, François Nosten, Philippe J. Guérin and Rose McGready
Malaria Journal 2017 16:491, 18 December 2017

Incomplete reporting and varied methodological assessment of pregnancy outcomes in anti-malarial drug efficacy studies limits comparison across studies


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