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falciparum malaria

An automated haematology analyzer XN-30 distinguishes developmental stages of falciparum malaria parasite cultured in vitro

February 6, 2018 - 17:19 -- Open Access
Author(s): 
Takahiro Tougan, Yuhgi Suzuki, Sawako Itagaki, Munehisa Izuka, Yuji Toya, Kinya Uchihashi and Toshihiro Horii
Reference: 
Malaria Journal 2018 17:59, 2 February 2018

The XN-30 analyzer allows the precise recognition and enumeration of total and each developmental stages of cultured falciparum parasites, and permits the sensitive and reproducible calculation of parasitaemia.

NOT Open Access | Evaluation of rapid PfHRP-2/pLDH-based tests in diagnosing microscopy-confirmed falciparum malaria in Hodeidah governorate, Yemen

January 2, 2018 - 15:02 -- NOT Open Access
Author(s): 
Ahmed A. Azazy, Ali Jamaly Alhawery, Rashad Abdul-Ghani, R.A. Alharbi, Shaia S.R. Almalki
Reference: 
Acta Tropica Volume 178, February 2018, Pages 252–257

Along with the determination of malaria infection rate among suspected patients attending hospitals in Hodeidah governorate, the present study evaluated the accuracy of Plasmodium falciparum histidine-rich protein-2 (PfHRP-2)/parasite-specific lactate dehydrogenase (pLDH)-based rapid diagnostic test (RDT) for the diagnosis of microscopy-confirmed falciparum malaria.

Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review

December 19, 2017 - 15:24 -- Open Access
Author(s): 
Makoto Saito, Mary Ellen Gilder, François Nosten, Philippe J. Guérin and Rose McGready
Reference: 
Malaria Journal 2017 16:491, 18 December 2017

Incomplete reporting and varied methodological assessment of pregnancy outcomes in anti-malarial drug efficacy studies limits comparison across studies

Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges

December 13, 2017 - 15:52 -- Open Access
Author(s): 
Makoto Saito, Mary Ellen Gilder, François Nosten, Rose McGready and Philippe J. Guérin
Reference: 
Malaria Journal 2017 16:488, 13 December 2017

Efficacy studies in pregnancy are not only limited in number but use varied methodological assessments. In five RCTs with comparable methodology, ABT resulted in higher efficacy than QBT in the second and third trimester of pregnancy.

Medical Treatment: 

Therapeutic efficacy of artesunate - amiodaquine for treating uncomplicated falciparum malaria at Ghindae Zonal Referral Hospital, Eritrea

November 3, 2017 - 05:56 -- Open Access
Author(s): 
Abdu O. Mohammed, Seltene Tewolde, Dawit Estifanos, Yohannes Tekeste, Mohammed-hamid Osman
Reference: 
Acta Tropica Volume 177, January 2018, Pages 94-96

Therapeutic efficacy of AS + AQ still meets the WHO efficacy criteria for its continued use in the study area as the first-line drug against uncomplicated falciparum malaria.

NOT Open Access | RANTES levels as a determinant of falciparum malaria severity or recovery

August 23, 2017 - 16:02 -- NOT Open Access
Author(s): 
D. Bujarbaruah, M. P. Kalita, V. Baruah, T. K. Basumatary, S. Hazarika, R. H. Begum, S. Medhi and S. Bose
Reference: 
Parasite Immunology, Volume 39, Issue 9 September 2017, e12452

The study explored the role of differential RANTES concentrations, its receptor CCR5 expression and resulting immunomodulation in the pathogenesis and/or recovery from falciparum malaria.

Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women

July 5, 2017 - 14:21 -- Open Access
Author(s): 
Ritah F. Mutagonda, Appolinary A. R. Kamuhabwa, Omary M. S. Minzi, Siriel N. Massawe, Muhammad Asghar, Manijeh V. Homann, Anna Färnert and Eleni Aklillu
Reference: 
Malaria Journal 2017 16:267, 3 July 2017

Genetic variations in CYP3A4 and CYP3A5may influence LF pharmacokinetics and treatment outcome in pregnant women.

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Medical Treatment: 

NOT Open Access | Efficacy and safety of artemether–lumefantrine for the treatment of uncomplicated falciparum malaria at sentinel sites in Mozambique, 2015

June 20, 2017 - 14:36 -- NOT Open Access
Author(s): 
Crizolgo Salvador, Bernardete Rafael, Sónia Enosse, et al.
Reference: 
Acta Tropica, Volume 171, July 2017, Pages 146–150

The resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control.

Medical Treatment: 

Molecular surveillance of artemisinin resistance falciparum malaria among migrant goldmine workers in Myanmar

March 9, 2017 - 14:45 -- Open Access
Author(s): 
Myat Htut Nyunt, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Jin-Hee Han, Seong-Kyun Lee, Kay Thwe Han, Ye Htut and Eun-Taek Han
Reference: 
Malaria Journal 2017 16:97, 1 March 2017

High mutant rate of artemisinin resistance markers and relatively high pfmdr1 copy number among isolates collected from migrant goldmine workers alert the importance of containment measures among this target population.

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The role of early detection and treatment in malaria elimination

July 19, 2016 - 16:20 -- Open Access
Author(s): 
Jordi Landier, Daniel M. Parker, François H. Nosten, et al.
Reference: 
Malaria Journal 2016 15:363, 15 July 2016

Falciparum malaria persists in hard-to-reach areas or demographic groups that are missed by conventional healthcare systems but could be reached by trained community members in a malaria post (MP).

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