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falciparum malaria

Efficacy of antimalarial drugs for treatment of uncomplicated falciparum malaria in Asian region: A network meta-analysis

December 23, 2019 - 16:09 -- Open Access
Naing C, Whittaker MA, Htet NH, Aye SN, Mak JW
PLoS ONE 14(12): e0225882

The WHO recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated falciparum malaria. Hence, monitoring the efficacy of antimalarial drugs is a key component of malaria control and elimination. The published randomized trials that assessed comparisons of ACTs for treating uncomplicated falciparum malaria reported conflicting results in treatment efficacy. A network meta-analysis is an extension of pairwise meta-analysis that can synthesize evidence simultaneously from both direct and indirect treatment comparisons. The objective was to synthesize evidence on the comparative efficacy of antimalarial drugs for treatment of uncomplicated falciparum malaria in Asian region.

NOT Open Access | Association of lipid levels with mefloquine and carboxy-mefloquine concentrations in patients with uncomplicated falciparum malaria

December 23, 2019 - 15:12 -- NOT Open Access
Vieira JLF, Rivera JGB, de Sena LWP, Ferreira MVD
Antimicrob Agents Chemother. 2019 Dec 16. pii: AAC.01731-19

Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria.

Investigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies

September 9, 2019 - 16:47 -- Open Access
Stije J. Leopold, James A. Watson, Atthanee Jeeyapant, Julie A. Simpson, Nguyen H. Phu, Tran T. Hien, Nicholas P. J. Day, Arjen M. Dondorp, Nicholas J. White
PLoS Med 16(8): e1002858

Severe falciparum malaria is a medical emergency characterised by potentially lethal vital organ dysfunction. Patient fatality rates even with parenteral artesunate treatment remain high. Despite considerable research into adjuvant therapies targeting organ and tissue dysfunction, none have shown efficacy apart from renal replacement therapy. Understanding the causal contributions of clinical and laboratory abnormalities to mortality is essential for the design and evaluation of novel therapeutic interventions.

High therapeutic efficacy of artemether–lumefantrine and dihydroartemisinin–piperaquine for the treatment of uncomplicated falciparum malaria in Somalia

July 12, 2019 - 16:32 -- Open Access
Marian Warsame, Abdillahi Mohamed Hassan, Pascal Ringwald, et al.
Malaria Journal 2019 18:231, 11 July 2019

Artemether–lumefantrine (AL) and dihydroartemisinin–piperaquine (DHA/PPQ) are the recommended first- and second-line treatments, respectively, for uncomplicated falciparum malaria in Somalia. The studies reported here were conducted to assess the efficacy of these artemisinin-based combinations and the mutations in Plasmodium falciparum K13-propeller (Pfk13) domain and amplification in Pfplasmepsin 2 (Pfpm2) gene in Somalia.

Medical Treatment: 

Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

April 22, 2019 - 12:28 -- Open Access
Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A. Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn and Jean-René Kiechel
Malaria Journal 2019 18:139, 18 April 2019

The population pharmacokinetic models developed for both AS/DHA and MQ showed a large variability in drug exposure in the investigated African paediatric population.


Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study

March 27, 2019 - 15:53 -- Open Access
Hugh W. Kingston, Aniruddha Ghose, Arjen M. Dondorp, et al.
Malaria Journal 2019 18:97, 25 March 2019

Reduced total oxygen delivery is not a major contributor to lactic acidosis in severe falciparum malaria.

NOT Open Access | Identification of potential whole blood MicroRNA biomarkers for the blood stage of adult imported falciparum malaria through integrated mRNA and miRNA expression profiling

November 28, 2018 - 15:25 -- NOT Open Access
Jing-jing Li, Min-jun Huang, Zhen Li, Wei Li, Fei Wang, Lei Wang, Xiao-li Li, Xiaoyan Zheng, Yang Zou
Biochemical and Biophysical Research Communications Volume 506, Issue 3, 30 November 2018, Pages 471-477

Correlating aberrant miRNA levels with imported malaria during the blood stage is required to better understand the in vivo biological and molecular processes that are involved in the response to Plasmodium falciparum infection and to find new biomarkers and diagnosis tools.

Identifying risk factors for the development of sepsis during adult severe malaria

July 31, 2018 - 15:32 -- Open Access
Tsi Njim, Arjen Dondorp, Mavuto Mukaka and Eric O. Ohuma
Malaria Journal 2018 17:278, 31 July 2018

The proposed model identifies patients with severe malaria at risk of developing clinical sepsis, potentially benefiting from antibiotic treatment in addition to anti-malarials.

Pharmacokinetics of mefloquine administered with artesunate in patients with uncomplicated falciparum malaria from the Brazilian Amazon basin

July 17, 2018 - 15:55 -- Open Access
Michelle V. D. Ferreira, José L. F. Vieira, Eduardo D. Almeida, Juan G. B. Rivera, Margarete S. M. Gomes and André M. de Siqueira
Malaria Journal 2018 17:268, 16 July 2018

The pharmacokinetic parameters of mefloquine determined in the study suggest an adequate exposure of parasite to mefloquine in the multiple oral dose regimen of the fixed dose combination of mefloquine and artesunate.

Effectiveness and safety of 3 and 5 day courses of artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in an area of emerging artemisinin resistance in Myanmar

July 15, 2018 - 16:52 -- Open Access
Kyaw Myo Tun, Atthanee Jeeyapant, Frank Smithuis, et al.
Malaria Journal 2018 17:258, 11 July 2018

Despite a high prevalence of k13 mutations, the current first-line treatment, AL, was still highly effective in this area of South-East Myanmar.

Medical Treatment: 


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