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falciparum

A protocol for systematic review and meta-analysis of optimizing treatment for malaria

September 12, 2020 - 14:56 -- Open Access
Author(s): 
Zhang R, Dong X, Wang J, Guo Y, Dai Y
Reference: 
Medicine (Baltimore). 2020 Sep 4;99(36):e22044

Malaria remains a global health threat for centuries. In recent years, a rising resistance of Plasmodium falciparum to current standard artemisinin-based combination therapies (ACTs) leads to increasing treatment failures and requires for optimized treatment. Here, we intend to make a systematic review and meta-analysis of optimizing treatment for malaria, so as to find a potential optimal treatment.

NOT Open Access | Decreased Mortality of falciparum Malaria in Anemic Prisoners of War

September 10, 2020 - 08:46 -- NOT Open Access
Author(s): 
Shanks GD
Reference: 
Am J Trop Med Hyg. 2020 Sep 8

Modern clinical trials have suggested that anemia protects against malaria mortality. Military records of the Second World War in Asia were examined to see if there was support for this hypothesis. When relatively well-nourished Imperial Japanese Navy sailors captured on Nauru (n = 799) were imprisoned on the Fauro Islands, 26% died from falciparum malaria.

Not Open Access | In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs

September 5, 2020 - 15:53 -- NOT Open Access
Author(s): 
Ding S, Fike KR, Klemba M, Carlier PR
Reference: 
Bioorg Med Chem Lett. 2020 Sep 1;30(17):127348

Antimalarial candidates possessing novel mechanisms of action are needed to control drug resistant Plasmodium falciparum. We were drawn to Malaria Box compound 1 (MMV665831) by virtue of its excellent in vitro potency, and twelve analogs were prepared to probe its structure–activity relationship. Modulation of the diethyl amino group was fruitful, producing compound 25, which was twice as potent as 1 against cultured parasites.

NOT Open Access | Climate based malaria forecasting system for Andhra Pradesh, India

September 5, 2020 - 15:51 -- NOT Open Access
Author(s): 
Mopuri R, Kakarla SG, Mutheneni SR, Kadiri MR, Kumaraswamy S
Reference: 
J Parasit Dis. 2020 Sep;44(3):497-510

Malaria is a major public health problem in tropical and subtropical countries of the World. During the year 1999, Visakhapatnam district of Andhra Pradesh, India experienced a major epidemic of malaria, and nearly 41,805 cases were reported. Hence, a retrospective malaria surveillance study was conducted from 2001 to 2016 and reported nearly a total of 149,317 malaria cases during the study period.

NOT Open Access | Comparision of the various routine diagnostic modalities of malaria and a new method: the Parasight™ platform

September 5, 2020 - 15:49 -- NOT Open Access
Author(s): 
Das S, Rajkumari N, Revathi U, Gururajan A
Reference: 
J Parasit Dis. 2020 Sep;44(3):528-535

Malaria is one of most important parasitic disease, which is still much prevalent in India. The burden of malaria in India is complex and the proportions of Plasmodium vivax and Plasmodium falciparum vary across India, because of the highly variable malaria eco-epidemiological profiles, transmission factors, and the presence of multiple Plasmodium species and Anopheles vectors.

Utility of ultra-sensitive qPCR to detect Plasmodium falciparum and Plasmodium vivax infections under different transmission intensities

September 5, 2020 - 14:51 -- Open Access
Author(s): 
Maria Gruenberg, Clara Antunes Moniz, Ingrid Felger, et al.
Reference: 
Malaria Journal 2020 19:319, 3 September 2020

The use of molecular diagnostics has revealed an unexpectedly large number of asymptomatic low-density malaria infections in many malaria endemic areas. This study compared the gains in parasite prevalence obtained by the use of ultra-sensitive (us)-qPCR as compared to standard qPCR in cross-sectional surveys conducted in Thailand, Brazil and Papua New Guinea (PNG). The compared assays differed in the copy number of qPCR targets in the parasite genome.

Misdiagnosis of imported falciparum malaria from African areas due to an increased prevalence of pfhrp2/pfhrp3 gene deletion: The Djibouti case

September 2, 2020 - 08:33 -- Open Access
Author(s): 
Iriart X, Menard S, Chauvin P, Mohamed HS, Charpentier E, Mohamed MA, Berry A, Aboubaker MH
Reference: 
Emerg Microbes Infect. 2020 Sep 1:1-9

A case of imported falciparum malaria acquired in Djibouti was diagnosed in 2019 in the Toulouse University Hospital (France) by microscopy and a positive P. falciparum specific real-time PCR (qPCR).

Genetic analysis of the orthologous crt and mdr1 genes in Plasmodium malariae from Thailand and Myanmar

September 1, 2020 - 10:28 -- Open Access
Author(s): 
Yupawadee Pimpat, Naowarat Saralamba, Usa Boonyuen, Sasithon Pukrittayakamee, Francois Nosten, Frank Smithuis, Nicholas P. J. Day, Arjen M. Dondorp and Mallika Imwong
Reference: 
Malaria Journal 2020 19:315, 31 August 2020

Plasmodium malariae is a widely spread but neglected human malaria parasite, which causes chronic infections. Studies on genetic polymorphisms of anti-malarial drug target genes in P. malariae are limited. Previous reports have shown polymorphisms in the P. malariae dihydrofolate reductase gene associated with pyrimethamine resistance and linked to pyrimethamine drug pressure. This study investigated polymorphisms of the P. malariae homologous genes, chloroquine resistant transporter and multidrug resistant 1, associated with chloroquine and mefloquine resistance in Plasmodium falciparum.

Quantification of Plasmodium knowlesi versus Plasmodium falciparum in the rhesus liver: implications for malaria vaccine studies in rhesus models

September 1, 2020 - 10:12 -- Open Access
Author(s): 
Melanie J. Shears, Annette M. Seilie, B. Kim Lee Sim, Stephen L. Hoffman and Sean C. Murphy
Reference: 
Malaria Journal 2020 19:313, 31 August 2020

Rhesus macaques are valuable pre-clinical models for malaria vaccine development. The Plasmodium knowlesi/rhesus and Plasmodium falciparum/rhesus models are two established platforms for malaria vaccine testing, and both have previously been used to assess live-attenuated sporozoite vaccines. However, there is evidence that the susceptibility of the rhesus liver to P. knowlesi versus P. falciparum sporozoites likely differs, potentially complicating comparisons between these two platforms.

Differential contribution of Anopheles coustani and Anopheles arabiensis to the transmission of Plasmodium falciparum and Plasmodium vivax in two neighbouring villages of Madagascar

August 27, 2020 - 08:17 -- Open Access
Author(s): 
Goupeyou-Youmsi J, Rakotondranaivo T, Puchot N, Peterson I, Girod R, Vigan-Womas I, Paul R, Ndiath MO, Bourgouin C
Reference: 
Parasit Vectors. 2020 Aug 26;13(1):430

Malaria is still a heavy public health concern in Madagascar. Few studies combining parasitology and entomology have been conducted despite the need for accurate information to design effective vector control measures. In a Malagasy region of moderate to intense transmission of both Plasmodium falciparum and P. vivax, parasitology and entomology have been combined to survey malaria transmission in two nearby villages.

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