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falciparum

Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors

August 26, 2016 - 15:19 -- Open Access
Author(s): 
Aung Pyae Phyo, Elizabeth A. Ashley, Francois Nosten, et al.
Reference: 
Clin Infect Dis. (2016) 63 (6): 784-791

Between 2003 and 2013, we studied the efficacy of MAS3 in 1005 patients with uncomplicated P. falciparum malaria in relation to molecular markers of resistance.

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Not Open Access | Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children with Falciparum Malaria

October 28, 2014 - 16:24 -- NOT Open Access
Author(s): 
Tsin W. Yeo, Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, J. Brice Weinberg, Donald L. Granger, Ric N. Price and Nicholas M. Anstey
Reference: 
J Infect Dis. (2014) 210 (10): 1627-1632.

We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria.

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

July 21, 2014 - 16:38 -- Open Access
Author(s): 
Rebecca D. Oppenheim, Darren J. Creek, Dominique Soldati-Favre, et al.
Reference: 
PLoS Pathog 10(7): e1004263

While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.

Participants' perceptions and understanding of a malaria clinical trial in Bangladesh

June 10, 2014 - 15:41 -- Open Access
Tags: 
Author(s): 
Das D, Cheah PY, Faiz A, et al.
Reference: 
Malaria Journal 2014, 13 :217 (4 June 2014)

There is frequently a degree of overlap between research and provision of clinical care in malaria research studies.

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Not Open Access | Effectiveness of artesunate–amodiaquine vs. artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Nanoro, Burkina Faso: a non-inferiority randomised trial

April 2, 2014 - 18:23 -- NOT Open Access
Author(s): 
Halidou Tinto, Salou Diallo, Umberto D'Alessandro, et al.
Reference: 
Tropical Medicine & International Health, Volume 19, Issue 4, pages 469–475, April 2014

We report here the results of a study assessing the effectiveness of the two ACTs currently recommended in Burkina Faso for the treatment of uncomplicated malaria, that is, artemether–lumefantrine (AL) and artesunate–amodiaquine (ASAQ).

Research: Persistence of markers of chloroquine resistance among P. falciparum isolates recovered from two Nigerian communities

February 27, 2014 - 22:36 -- Ingeborg van Schayk
Author(s): 
Yetunde A. Olukosi, Muyiwa K. Oyebola, Olusola Ajibaye, Bassey A. Orok, Olugbenga O. Aina, Chimere O. Agomo, Bamidele A. Iwalokun, Samuel K. Akindele, Veronica N.V. Enya, Hilary I. Okoh
Reference: 
MWJ 2014, 5, 3

We investigated the prevalence of the major markers of chloroquine resistance years after the withdrawal of the drug in Nigeria.
 Finger prick blood samples were collected from participants presenting with symptoms of malaria in Lagos, Nigeria.

Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review

February 19, 2014 - 21:09 -- Ingeborg van Schayk
Author(s): 
J. Church and K. Maitland
Reference: 
BMC Medicine 2014, 12:31

Background
Severe malaria remains a major cause of pediatric hospital admission across Africa. Invasive bacterial infection (IBI) is a recognized complication of Plasmodium falciparum malaria, resulting in a substantially worse outcome. Whether a biological relationship exists between malaria infection and IBI susceptibility remains unclear. We, therefore, examined the extent, nature and evidence of this association.

Malaria and Severe Anemia: Thinking beyond Plasmodium falciparum

January 3, 2014 - 14:10 -- Open Access
Author(s): 
Roly D. Gosling, Michelle S. Hsiang
Reference: 
PLoS Med 10(12): e1001576

In this week's PLOS Medicine, Ric Price and colleagues compare the burden of anemia in different plasmodia species in a robust hospital-based surveillance study in Eastern Indonesia.

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Not Open Access | Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of falciparum and vivax malaria

December 10, 2013 - 15:58 -- NOT Open Access
Author(s): 
Jennifer S. Armistead, Isabelle Morlais, Derrick K. Mathias, Juliette G. Jardim, Jaimy Joy, Arthur Fridman, Adam C. Finnefrock, Ansu Bagchi, Magdalena Plebanski, Diana G. Scorpio, Thomas S. Churcher, Natalie A. Borg, Jetsumon Sattabongkot and Rhoel R. Dinglasan
Reference: 
Infection and Immunity, December 2013, Volume 81, Issue 12

Malaria transmission-blocking vaccines (TBVs) represent a promising approach for the elimination and eradication of this disease. AnAPN1 is a lead TBV candidate that targets a surface antigen on the midgut of the obligate vector of the Plasmodium parasite, the Anopheles mosquito. In this study, we demonstrate that antibodies targeting AnAPN1 block transmission of Plasmodium falciparum and Plasmodium vivax across distantly related anopheline species in malaria endemic countries.

VIDEO ILLUSTRATED | Methodology: A protocol for membrane feeding assays to determine the infectiousness of P. falciparum naturally infected individuals to Anopheles gambiae

November 14, 2013 - 22:11 -- Ingeborg van Schayk
Author(s): 
André Lin Ouédraogo, Wamdaogo M Guelbéogo, Anna Cohuet, Isabelle Morlais, Jonas G. King, Bronner P. Gonçalves, Guido J. H. Bastiaens, Michiel Vaanhold, Fatimata Thiombiano, Jetsumon Sattabongkot, Yimin Wu, Mamadou Coulibaly, Baber Ibrahima, Sophie Jones, Merribeth Morin, Chris Drakeley, Rhoel R. Dinglasan, Teun Bousema
Reference: 
MWJ 2013, 4, 16

A detailed protocol for membrane feeding is presented, as well as a detailed assessment of the precision of membrane feeding assays by allowing batches of mosquitoes to feedon the same gametocytaemic bloodmeal.

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