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Cost-effectiveness of rapid diagnostic tests, compared to microscopic tests, for the diagnosis and treatment of gestational malaria in Colombia from an institutional perspective

November 11, 2020 - 14:22 -- Open Access
Deisy Cristina Restrepo-Posada, Jaime Carmona-Fonseca and Jaiberth Antonio Cardona-Arias
Malaria Journal 2020 19:400, 10 November 2020

Gestational malaria is associated with negative outcomes in maternal and gestational health; timely diagnosis is crucial to avoid complications. However, the limited infrastructure, equipment, test reagents, and trained staff make it difficult to use thick blood smear tests in rural areas, where rapid testing could be a viable alternative. The purpose of this study was to estimate the cost-effectiveness of rapid tests type III (Plasmodium falciparum/Plasmodium spp P.f/pan) versus microscopic tests for the diagnosis and treatment of gestational malaria in Colombia.

NOT Open Access | Spatial analysis of malaria in Kotabaru, South Kalimantan, Indonesia: an evaluation to guide elimination strategies

November 11, 2020 - 13:09 -- NOT Open Access
Juhairiyah J, Andiarsa D, Indriyati L, Ridha MR, Prasodjo RS, Dhewantara PW
Trans R Soc Trop Med Hyg. 2020 Nov 9:traa125

Malaria remains a significant public health concern in Indonesia. Knowledge about spatial patterns of the residual malaria hotspots is critical to help design elimination strategies in Kotabaru district, South Kalimantan, Indonesia.

Socio-economic behavioural indicators of falciparum malaria parasitaemia and moderate to severe anaemia among pregnant women attending antenatal clinics in Lagos, Southwest Nigeria

November 10, 2020 - 13:54 -- Open Access
Adeola Y. Olukosi, Abiodun Olakiigbe, Bamigboye M. Afolabi, et al.
Malaria Journal 2020 19:393, 7 November 2020

Incidence of malaria and anaemia are of public health importance especially in pregnant women in endemic regions, due to the negative health consequences to the mother and fetus. This study aimed to assess the pattern of falciparum malaria infection and anaemia, based on malaria prevention methods practiced by participants.

Development of a Multiplex Loop-Mediated Isothermal Amplification (LAMP) Method for Simultaneous Detection of Spotted Fever Group Rickettsiae and Malaria Parasites by Dipstick DNA Chromatography

November 7, 2020 - 12:42 -- Open Access
Moonga LC, Hayashida K, Kawai N, Nakao R, Sugimoto C, Namangala B, Yamagishi J
Diagnostics (Basel). 2020 Nov 2;10(11):E897

Spotted fever group (SFG) rickettsiae causes febrile illness in humans worldwide. Since SFG rickettsiosis's clinical presentation is nonspecific, it is frequently misdiagnosed as other febrile diseases, especially malaria, and complicates proper treatment. Aiming at rapid, simple, and simultaneous detection of SFG Rickettsia spp. and Plasmodium spp., we developed a novel multiple pathogen detection system by combining a loop-mediated isothermal amplification (LAMP) method and dipstick DNA chromatography technology.

Rapid diagnostic tests for Plasmodium vivax malaria in endemic countries

November 7, 2020 - 12:30 -- Open Access
Agarwal R, Choi L, Johnson S, Takwoingi Y
Cochrane Database Syst Rev. 2020 Nov 4;11:CD013218

Plasmodium vivax (P vivax) is a focus of malaria elimination. It is important because P vivax and Plasmodium falciparum infection are co‐endemic in some areas. There are asymptomatic carriers of P vivax, and the treatment for P vivax and Plasmodium ovale malaria differs from that used in other types of malaria. Rapid diagnostic tests (RDTs) will help distinguish P vivax from other malaria species to help treatment and elimination. There are RDTs available that detect P vivax parasitaemia through the detection of P vivax‐specific lactate dehydrogenase (LDH) antigens.

Malaria in Sundargarh district, Odisha, India: Epidemiological and behavioral aspects from surveys

November 4, 2020 - 15:57 -- Open Access
van Eijk AM, Choubey S, Barla P, Haque MA, Nandini P, Acharya S, Sullivan SA, Mohanty S, Satpathi S, Carlton JM
Acta Trop. 2020 Nov;211:105647. doi: 10.1016/j.actatropica

To characterize malaria and assist in prevention efforts, we conducted a series of epidemiological studies in Sundargarh district, India, as part of an NIH-funded International Center of Excellence for Malaria Research. In a published survey around Rourkela in 2013-2014 (N = 1307), malaria prevalence was found to be 8.3%. Using these data, villages were divided into low (<2%), medium (2-10%) and high (>10%) malaria prevalence, and risk factors assessed by type of village. In the six low malaria villages, four persons were positive by PCR; in the four medium malaria villages, prevalence was 7% (35 infections, 7 P. vivax); and in the three high malaria villages, prevalence was 21% (62 infections, 10 P. vivax and 5 mixed with P. vivax and P. falciparum).

Acquired antibody responses against merozoite surface protein-1(19) antigen during Plasmodium falciparum and P.vivax infections in South Indian city of Mangaluru

October 31, 2020 - 09:30 -- Open Access
Punnath K, Dayanand KK, Midya V, Chandrashekar VN, Achur RN, Kakkilaya SB, Ghosh SK, Kumari SN, Gowda DC
J Parasit Dis. 2020 Oct 21:1-1

Merozoite surface protein-1 (MSP-1) of malaria parasites has been extensively studied as a malaria vaccine candidate and the antibody response to this protein is an important indicator of protective immunity to malaria. Mangaluru city and its surrounding areas in southwestern India are endemic to malaria with Plasmodium vivax being the most widespread and prevalent species although P. falciparum also frequently infects.

Factors associated with malaria in indigenous populations: A retrospective study from 2007 to 2016

October 22, 2020 - 15:54 -- Open Access
Meireles BM, de Souza Sampaio V, Monteiro WM, Gonçalves MJF
PLoS One. 2020 Oct 21;15(10):e0240741

In Brazil malaria is most frequent in the Amazon region, mainly in the Amazonas state, where it is found the most proportion of indigenous people of the whole country. It is remarkable publications about malaria in the Amazon, although information on malaria in indigenous populations is still poorly explored.

NOT Open Access | Therapeutic Efficacy of Artemether-Lumefantrine for Uncomplicated Falciparum Malaria in Northern Zambia

October 21, 2020 - 09:31 -- NOT Open Access
Ippolito MM, Pringle JC, Thuma PE, et al.
Am J Trop Med Hyg. 2020 Oct 19

Artemether-lumefantrine (AL) is a first-line agent for uncomplicated malaria caused by Plasmodium falciparum. The WHO recommends periodic therapeutic efficacy studies of antimalarial drugs for the detection of malaria parasite drug resistance and to inform national malaria treatment policies. We conducted a therapeutic efficacy study of AL in a high malaria transmission region of northern Zambia from December 2014 to July 2015.

Chloroquine Potentiates Primaquine Activity Against Active and Latent Hepatic Plasmodia Ex vivo: Potentials and Pitfalls

October 21, 2020 - 09:26 -- Open Access
Dembélé L, Franetich JF, Snounou G, et al.
Antimicrob Agents Chemother. 2020 Oct 19:AAC.01416-20

8-aminoquinoline compounds have long been the only therapeutic agents against latent hepatic malaria parasites. These have poor activity against the blood stage plasmodia causing acute malaria and must be used in conjunction with partner blood schizontocidal agents. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline, against hepatic stages of Plasmodium cynomolgi, Plasmodium yoelii, Plasmodium berghei, and Plasmodium falciparum within several ex vivo systems: primary hepatocytes of Macaca fascicularis; primary human hepatocytes; and stably transformed human hepatocarcinoma cell line HepG2.


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