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falciparum

Genomic surveillance of Plasmodium falciparum and Plasmodium vivax cases at the University Hospital in Tegucigalpa, Honduras

December 3, 2020 - 12:36 -- Open Access
Author(s): 
Valdivia HO, Villena FE, Lizewski SE, Garcia J, Alger J, Bishop DK
Reference: 
Sci Rep. 2020 Dec 1;10(1):20975

Malaria continues to be an important health problem in Honduras despite major progress achieved reducing its incidence in the last two decades. In a context of case reduction, continuing surveillance of parasite diversity and drug resistance is an important component to assist effective malaria control strategies and support risk assessments. In this study, we employed next generation sequencing on collected Plasmodium vivax and P. falciparum samples from the Hospital Escuela (University Hospital) in Honduras between 2005 and 2017.

NOT Open Access | Household prevalence of P. falciparum, P. vivax, and P. ovale in the Democratic Republic of the Congo, 2013-2014

December 3, 2020 - 12:31 -- NOT Open Access
Author(s): 
Mitchell CL, Topazian HM, Brazeau NF, Deutsch-Feldman M, Muwonga J, Sompwe E, Tshefu AK, Mwandagalirwa MK, Parr JB, Juliano JJ
Reference: 
Clin Infect Dis. 2020 Nov 26:ciaa1772

In a cross-sectional molecular study in the Democratic Republic of Congo, 78% of households had at least one member infected with Plasmodium falciparum, vivax, and/or ovale spp. 47% of children and 33% of adults tested positive for at least one species.

Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study

December 2, 2020 - 08:00 -- Open Access
Author(s): 
Rita Afriyie Boateng, Özlem Tastan Bishop and Thommas Mutemi Musyoka
Reference: 
Malaria Journal 2020 19:442, 30 November 2020

Plasmodial transketolase (PTKT) enzyme is one of the novel pharmacological targets being explored as potential anti-malarial drug target due to its functional role and low sequence identity to the human enzyme. Despite this, features contributing to such have not been exploited for anti-malarial drug design. Additionally, there are no anti-malarial drugs targeting PTKTs whereas the broad activity of these inhibitors against PTKTs from other Plasmodium spp. is yet to be reported. This study characterises different PTKTs [Plasmodium falciparum (PfTKT), Plasmodium vivax (PvTKT), Plasmodium ovale (PoTKT), Plasmodium malariae (PmTKT) and Plasmodium knowlesi (PkTKT) and the human homolog (HsTKT)] to identify key sequence and structural based differences as well as the identification of selective potential inhibitors against PTKTs.

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network

November 25, 2020 - 12:36 -- Open Access
Author(s): 
Hossain MS, Commons RJ, Price RN, et al.
Reference: 
PLoS Med. 2020 Nov 19;17(11):e1003393

There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to quantify this risk and the associated determinants using an individual patient data meta-analysis in order to identify populations in which a policy of universal radical cure, combining artemisinin-based combination therapy (ACT) with a hypnozoitocidal antimalarial drug, would be beneficial.

Prevalence, characteristics and risk factors of imported and local malaria cases in North-Western Province, Zambia: a cross-sectional study

November 24, 2020 - 15:08 -- Open Access
Author(s): 
Maureen N. Chipoya and Nzooma M. Shimaponda-Mataa
Reference: 
Malaria Journal 2020 19:430, 23 November 2020

Imported malaria is a major challenge for countries that are in malaria elimination stage such as Zambia. Legitimate cross-border activities add to the risk of transmission, necessitating determination of prevalence, characteristics and risk factors of imported and local malaria.

Performance evaluation of machine learning-based infectious screening flags on the HORIBA Medical Yumizen H550 Haematology Analyzer for vivax malaria and dengue fever

November 24, 2020 - 15:05 -- Open Access
Author(s): 
Parag Dharap and Sebastien Raimbault
Reference: 
Malaria Journal 2020 19:429, 23 November 2020

Automated detection of malaria and dengue infection has been actively researched for more than two decades. Although many improvements have been achieved, these solutions remain too expensive for most laboratories and clinics in developing countries. The low range HORIBA Medical Haematology Analyzer, Yumizen H550, now provides dedicated flags ‘vivax malaria’ and ‘dengue fever’ in routine blood testing, developed through machine learning methods, to be used as a screening tool for malaria and dengue fever in endemic areas. This study sought to evaluate the effectiveness of these flags under real clinical conditions.

Forest malaria in Cambodia: the occupational and spatial clustering of Plasmodium vivax and Plasmodium falciparum infection risk in a cross-sectional survey in Mondulkiri province, Cambodia

November 24, 2020 - 13:39 -- Open Access
Author(s): 
Mirco Sandfort, Amélie Vantaux, Ivo Mueller, et al.
Reference: 
Malaria Journal 2020 19:413, 19 November 2020

After a marked reduction in malaria burden in Cambodia over the last decades, case numbers increased again in 2017–2018. In light of the national goal of malaria elimination by 2025, remaining pockets of high risk need to be well defined and strategies well-tailored to identify and target the persisting burden cost-effectively. This study presents species-specific prevalence estimates and risk stratification for a remote area in Cambodia.

Multiplexed quantitative proteomics provides mechanistic cues for malaria severity and complexity

November 19, 2020 - 13:17 -- Open Access
Author(s): 
Kumar V, Ray S, Srivastava S, et al.
Reference: 
Commun Biol. 2020 Nov 17;3(1):683

Management of severe malaria remains a critical global challenge. In this study, using a multiplexed quantitative proteomics pipeline we systematically investigated the plasma proteome alterations in non-severe and severe malaria patients.

Spatial and genetic clustering of Plasmodium falciparum and Plasmodium vivax infections in a low-transmission area of Ethiopia

November 19, 2020 - 12:54 -- Open Access
Author(s): 
Tessema SK, Belachew M, Tadesse FG, et al.
Reference: 
Sci Rep. 2020 Nov 17;10(1):19975

The distribution of malaria infections is heterogeneous in space and time, especially in low transmission settings. Understanding this clustering may allow identification and targeting of pockets of transmission. In Adama district, Ethiopia, Plasmodium falciparum and P. vivax malaria patients and controls were examined, together with household members and immediate neighbors.

Measuring the contribution of human mobility to malaria persistence

November 12, 2020 - 15:51 -- Open Access
Author(s): 
Marcelo F. C. Gomes, Cláudia T Codeço, Leonardo S. Bastos and Raquel M. Lana
Reference: 
Malaria Journal 2020 19:404, 11 November 2020

To achieve malaria elimination, it is important to determine the role of human mobility in parasite transmission maintenance. The Alto Juruá basin (Brazil) exhibits one of the largest vivax and falciparum malaria prevalence in the Amazon. The goal of this study was to estimate the contribution of human commutes to malaria persistence in this region, using data from an origin-destination survey.

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