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falciparum

Research: Persistence of markers of chloroquine resistance among P. falciparum isolates recovered from two Nigerian communities

February 27, 2014 - 22:36 -- Ingeborg van Schayk
Author(s): 
Yetunde A. Olukosi, Muyiwa K. Oyebola, Olusola Ajibaye, Bassey A. Orok, Olugbenga O. Aina, Chimere O. Agomo, Bamidele A. Iwalokun, Samuel K. Akindele, Veronica N.V. Enya, Hilary I. Okoh
Reference: 
MWJ 2014, 5, 3

We investigated the prevalence of the major markers of chloroquine resistance years after the withdrawal of the drug in Nigeria.
 Finger prick blood samples were collected from participants presenting with symptoms of malaria in Lagos, Nigeria.

Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review

February 19, 2014 - 21:09 -- Ingeborg van Schayk
Author(s): 
J. Church and K. Maitland
Reference: 
BMC Medicine 2014, 12:31

Background
Severe malaria remains a major cause of pediatric hospital admission across Africa. Invasive bacterial infection (IBI) is a recognized complication of Plasmodium falciparum malaria, resulting in a substantially worse outcome. Whether a biological relationship exists between malaria infection and IBI susceptibility remains unclear. We, therefore, examined the extent, nature and evidence of this association.

Malaria and Severe Anemia: Thinking beyond Plasmodium falciparum

January 3, 2014 - 14:10 -- Open Access
Author(s): 
Roly D. Gosling, Michelle S. Hsiang
Reference: 
PLoS Med 10(12): e1001576

In this week's PLOS Medicine, Ric Price and colleagues compare the burden of anemia in different plasmodia species in a robust hospital-based surveillance study in Eastern Indonesia.

Country: 

Not Open Access | Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of falciparum and vivax malaria

December 10, 2013 - 15:58 -- NOT Open Access
Author(s): 
Jennifer S. Armistead, Isabelle Morlais, Derrick K. Mathias, Juliette G. Jardim, Jaimy Joy, Arthur Fridman, Adam C. Finnefrock, Ansu Bagchi, Magdalena Plebanski, Diana G. Scorpio, Thomas S. Churcher, Natalie A. Borg, Jetsumon Sattabongkot and Rhoel R. Dinglasan
Reference: 
Infection and Immunity, December 2013, Volume 81, Issue 12

Malaria transmission-blocking vaccines (TBVs) represent a promising approach for the elimination and eradication of this disease. AnAPN1 is a lead TBV candidate that targets a surface antigen on the midgut of the obligate vector of the Plasmodium parasite, the Anopheles mosquito. In this study, we demonstrate that antibodies targeting AnAPN1 block transmission of Plasmodium falciparum and Plasmodium vivax across distantly related anopheline species in malaria endemic countries.

VIDEO ILLUSTRATED | Methodology: A protocol for membrane feeding assays to determine the infectiousness of P. falciparum naturally infected individuals to Anopheles gambiae

November 14, 2013 - 22:11 -- Ingeborg van Schayk
Author(s): 
André Lin Ouédraogo, Wamdaogo M Guelbéogo, Anna Cohuet, Isabelle Morlais, Jonas G. King, Bronner P. Gonçalves, Guido J. H. Bastiaens, Michiel Vaanhold, Fatimata Thiombiano, Jetsumon Sattabongkot, Yimin Wu, Mamadou Coulibaly, Baber Ibrahima, Sophie Jones, Merribeth Morin, Chris Drakeley, Rhoel R. Dinglasan, Teun Bousema
Reference: 
MWJ 2013, 4, 16

A detailed protocol for membrane feeding is presented, as well as a detailed assessment of the precision of membrane feeding assays by allowing batches of mosquitoes to feedon the same gametocytaemic bloodmeal.

Public health system readiness to treat malaria in Odisha State of India

October 18, 2013 - 15:40 -- Open Access
Author(s): 
Mohammad A Hussain, Lalit Dandona, David Schellenberg
Reference: 
Malaria Journal 2013, 12:351 (2 October 2013)
MalariaWorld

The present study assessed the health system readiness to deploy RDTs and ACT for malaria control across the State.

Country: 

Not Open Access | Apoptosis and dysfunction of blood dendritic cells in patients with falciparum and vivax malaria

August 2, 2013 - 17:50 -- NOT Open Access
Author(s): 
Alberto Pinzon-Charry, Tonia Woodberry, Michael F. Good, et al.
Reference: 
JEM vol. 210 no. 8 1635-1646
MalariaWorld

We demonstrate that malaria patients display a significant reduction in circulating DC numbers and the concurrent accumulation of immature cells.

Malaria and haematologic parameters of pupils at different altitudes along the slope of Mount Cameroon: a cross-sectional study

June 14, 2013 - 13:37 -- Open Access
Author(s): 
Kimbi HK, Sumbele IU, Nweboh M, Anchang-Kimbi JK, Lum E, Nana Y, Ndip LM, Njom H, Lehman LG
Reference: 
Malaria Journal 2013, 12:193 (9 June 2013)
MalariaWorld

This study examines the influence of malaria status and altitude on haematologic parameters in school-aged pupils.

Country: 

Evaluation of the malaria rapid diagnostic test VIKIA malaria Ag Pf/PanTM in endemic and non-endemic settings

June 14, 2013 - 13:24 -- Open Access
Author(s): 
Eibach D, Traore B, Bouchrik M, Coulibaly B, Coulibaly N, Siby F, Bonnot G, Bienvenu A, Picot S
Reference: 
Malaria Journal 2013, 12:188 (6 June 2013)
MalariaWorld

This study aims to compare the new VIKIA Malaria Ag Pf/PanTM RDT with PCR-corrected microscopy results and the commonly used CareStartTM RDT to diagnose falciparum and non-falciparum malaria in the endemic setting of Bamako, Mali and the non-endemic setting of Lyon, France.

Predictive value of lymphocytopenia and the neutrophil-lymphocyte count ratio for severe imported malaria

March 20, 2013 - 13:35 -- Open Access
Author(s): 
van Wolfswinkel ME, Vliegenthart-Jongbloed K, de Mendonça Melo M, Wever PC, McCall MB, Koelewijn R, van Hellemond JJ, van Genderen PJ
Reference: 
Malaria Journal 2013, 12:101 (18 March 2013
MalariaWorld

The NLCR was found to correlate with parasitaemia, but both lymphocytopenia and the NLCR were inferior to C-reactive protein as markers for severe disease in patients with imported malaria

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