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falciparum

An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia

August 15, 2017 - 16:18 -- Open Access
Author(s): 
Leang R, Khu N, Mukaka M, Debackere M, Tripura R, Kheang S, Chy S, Kak N, Buchy P, Tarantola A, Menard D, Roca-Felterer A, Fairhurst R, Kheng S, Muth S, Ngak S, Dondorp A, White N, Taylor W
Reference: 
BMC Medicine 2016, 14 :171 (27 October 2016)

In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to block the transmission of Plasmodium falciparum without testing for glucose-6-phosphate dehydrogenase deficiency. 

Clinical and molecular surveillance of artemisinin resistant falciparum malaria in Myanmar (2009–2013)

August 15, 2017 - 14:40 -- Open Access
Author(s): 
Myat Htut Nyunt, Myat Thu Soe, Hla Win Myint, Htet Wai Oo, Moe Moe Aye, Soe Soe Han, Ni Ni Zaw, Cho Cho, Phyo Zaw Aung, Khin Thiri Kyaw, Thin Thin Aye, Naychi Aung San, Leonard Ortega, Krongthong Thimasarn, Maria Dorina G. Bustos, Sherwin Galit…
Reference: 
Malaria Journal 2017 16:333, 14 August 2017

Apart from k13, pfarps10, pffd and pfmdr2 are also useful for molecular surveillance of artemisinin resistance especially where k13 mutation has not been reported.

Life-span of in vitro differentiated Plasmodium falciparum gametocytes

August 15, 2017 - 14:37 -- Open Access
Author(s): 
Tamirat Gebru, Albert Lalremruata, Peter G. Kremsner, Benjamin Mordmüller and Jana Held
Reference: 
Malaria Journal 2017 16:330, 11 August 2017

Plasmodium falciparum mature gametocytes can survive up to 16–32 days (at least 14 days for mature male gametocytes) in vitro in absence of the influence of host factors.

NOT Open Access | An in silico strategy for identification of novel drug targets against Plasmodium falciparum

August 14, 2017 - 15:58 -- NOT Open Access
Author(s): 
Subhashree Rout, Namrata Priyadarshini Patra & Rajani Kanta Mahapatra
Reference: 
Parasitology Research, September 2017, Volume 116, Issue 9, pp 2539–2559

The apicomplexan parasite Plasmodium falciparum is responsible for global malaria burden. With the reported resistance to artemisinin chemotherapy, there is an urgent need to maintain early phase drug discovery and identify novel drug targets for successful eradication of the pathogen from the host.

Superbug: an emerging and quickly spreading threat to the race against malaria

February 17, 2017 - 09:46 -- Salomé Beaujouan

While the malaria death count in Cambodia dropped to just one case in 2016, a new threat to the race against the disease arises in south-eastern Asia: superbugs. A superbug is a drug-resistant, human-killing parasite that modern medicine struggles to combat.

Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors

August 26, 2016 - 15:19 -- Open Access
Author(s): 
Aung Pyae Phyo, Elizabeth A. Ashley, Francois Nosten, et al.
Reference: 
Clin Infect Dis. (2016) 63 (6): 784-791

Between 2003 and 2013, we studied the efficacy of MAS3 in 1005 patients with uncomplicated P. falciparum malaria in relation to molecular markers of resistance.

Country: 

Not Open Access | Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children with Falciparum Malaria

October 28, 2014 - 16:24 -- NOT Open Access
Author(s): 
Tsin W. Yeo, Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, J. Brice Weinberg, Donald L. Granger, Ric N. Price and Nicholas M. Anstey
Reference: 
J Infect Dis. (2014) 210 (10): 1627-1632.

We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria.

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

July 21, 2014 - 16:38 -- Open Access
Author(s): 
Rebecca D. Oppenheim, Darren J. Creek, Dominique Soldati-Favre, et al.
Reference: 
PLoS Pathog 10(7): e1004263

While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.

Participants' perceptions and understanding of a malaria clinical trial in Bangladesh

June 10, 2014 - 15:41 -- Open Access
Tags: 
Author(s): 
Das D, Cheah PY, Faiz A, et al.
Reference: 
Malaria Journal 2014, 13 :217 (4 June 2014)

There is frequently a degree of overlap between research and provision of clinical care in malaria research studies.

Country: 

Not Open Access | Effectiveness of artesunate–amodiaquine vs. artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Nanoro, Burkina Faso: a non-inferiority randomised trial

April 2, 2014 - 18:23 -- NOT Open Access
Author(s): 
Halidou Tinto, Salou Diallo, Umberto D'Alessandro, et al.
Reference: 
Tropical Medicine & International Health, Volume 19, Issue 4, pages 469–475, April 2014

We report here the results of a study assessing the effectiveness of the two ACTs currently recommended in Burkina Faso for the treatment of uncomplicated malaria, that is, artemether–lumefantrine (AL) and artesunate–amodiaquine (ASAQ).

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