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falciparum

Molecular surveillance of Pfcrt and k13 propeller polymorphisms of imported Plasmodium falciparum cases to Zhejiang Province, China between 2016 and 2018

February 10, 2020 - 16:08 -- Open Access
Author(s): 
Xiaoxiao Wang, Wei Ruan, Shuisen Zhou, Fang Huang, Qiaoyi Lu, Xinyu Feng and He Yan
Reference: 
Malaria Journal 2020 19:59, 4 February 2020

Resistance to anti-malarial drugs hinders malaria elimination. Monitoring the molecular markers of drug resistance helps improve malaria treatment policies. This study aimed to assess the distribution of molecular markers of imported Plasmodium falciparum infections.

Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago

February 3, 2020 - 17:01 -- Open Access
Author(s): 
Andrew P. Morgan, Nicholas F. Brazeau, Jonathan J. Juliano, et al.
Reference: 
Malaria Journal 2020 19:47, 28 January 2020

Tanzania’s Zanzibar archipelago has made significant gains in malaria control over the last decade and is a target for malaria elimination. Despite consistent implementation of effective tools since 2002, elimination has not been achieved. Importation of parasites from outside of the archipelago is thought to be an important cause of malaria’s persistence, but this paradigm has not been studied using modern genetic tools.

Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether–lumefantrine

January 24, 2020 - 14:49 -- Open Access
Author(s): 
Seif Shekalaghe, Dominic Mosha, Ali Hamad, Thabit A. Mbaga, Michael Mihayo, Teun Bousema, Chris Drakeley and Salim Abdulla
Reference: 
Malaria Journal 2020 19:34, 21 January 2020

Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for prevention of Plasmodium falciparum malaria transmission. Primaquine has been administered together on the first or the last day of conventional treatment but the impact of primaquine timing has never been examined. This study aimed to assess safety, efficacy and optimal timing of single full-dose (0.75 mg/kg) primaquine when added to a standard 6-dose regimen of artemether–lumefantrine (AL).

Clustering of asymptomatic Plasmodium falciparum infection and the effectiveness of targeted malaria control measures

January 24, 2020 - 14:47 -- Open Access
Author(s): 
Jeffrey G. Shaffer, Mahamoudou B. Touré, Nafomon Sogoba, Seydou O. Doumbia, Jules F. Gomis, Mouhamadou Ndiaye, Daouda Ndiaye, Ayouba Diarra, Ismaela Abubakar, Abdullahi Ahmad, Muna Affara, Davis Nwakanma, Mary Lukowski, James C. Welty, Frances J. Mather, Joseph Keating & Donald J. Krogstad
Reference: 
Malaria Journal 2020 19:33, 21 January 2020

Because clustering of Plasmodium falciparum infection had been noted previously, the clustering of infection was examined at four field sites in West Africa: Dangassa and Dioro in Mali, Gambissara in The Gambia and Madina Fall in Senegal.

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

December 23, 2019 - 14:55 -- Open Access
Author(s): 
de Jong RM, Tebeje SK, Meerstein-Kessel L, Tadesse FG, Jore MM, Stone W, Bousema T
Reference: 
Immunol Rev. 2019 Dec 16.

The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to mosquitoes. Here, we summarize evidence for naturally acquired anti‐gametocyte immunity and the current state of transmission blocking vaccines (TBV). Although gametocytes are intra‐erythrocytic when present in infected humans, developing Plasmodium falciparum gametocytes may express proteins on the surface of red blood cells that elicit immune responses in naturally exposed individuals.

Artenimol–piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort

December 17, 2019 - 16:36 -- Open Access
Author(s): 
Lauren Pull, Jean-Marc Lupoglazoff, Matthew Beardmore, Jean-François Michel, Pierre Buffet, Olivier Bouchaud and Jean-Yves Siriez
Reference: 
Malaria Journal 2019 18:419, 16 December 2019

Although malaria remains one of the major public health threats in inter-tropical areas, there is limited understanding of imported malaria in children by paediatricians and emergency practitioners in non-endemic countries, often resulting in misdiagnosis and inadequate treatment. Moreover, classical treatments (atovaquone-proguanil, quinine, mefloquine) are limited either by lengthy treatment courses or by side effects. Since 2010, the World Health Organization (WHO) has recommended the use of oral artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria worldwide. The benefits of artenimol–piperaquine in children have been validated in endemic countries but experience remains limited in cases of imported malaria.

A patatin-like phospholipase functions during gametocyte induction in the malaria parasite Plasmodium falciparum

November 18, 2019 - 16:21 -- Open Access
Author(s): 
Flammersfeld A, Panyot A, Yamaryo-Botté Y, Aurass P, Przyborski JM, Flieger A, Botté C, Pradel G.
Reference: 
Cell Microbiol. 2019 Nov 16:e13146

Patatin-like phospholipases (PNPLAs) are highly conserved enzymes of prokaryotic and eukaryotic organisms with major roles in lipid homeostasis. The genome of the malaria parasite Plasmodium falciparum encodes four putative PNPLAs with predicted functions during phospholipid degradation.

Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review

September 10, 2019 - 15:34 -- Open Access
Author(s): 
Abel Kakuru, Sarah G. Staedke, Grant Dorsey, Stephen Rogerson and Daniel Chandramohan
Reference: 
Malaria Journal 2019 18:304, 3 September 2019

Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium falciparum malaria infection during pregnancy, and intermittent preventive treatment of malaria during pregnancy (IPTp), on the risk of clinical malaria or parasitaemia during infancy.

Methods

Applying next-generation sequencing to track falciparum malaria in sub-Saharan Africa

September 10, 2019 - 15:31 -- Open Access
Author(s): 
Sofonias K. Tessema, Jaishree Raman, Craig W. Duffy, Deus S. Ishengoma, Alfred Amambua-Ngwa and Bryan Greenhouse
Reference: 
Malaria Journal 2019 18:268, 3 September 2019

Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions.

Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities and challenges

September 10, 2019 - 15:29 -- Open Access
Author(s): 
Deus S. Ishengoma, Queen Saidi, Carol H. Sibley, Cally Roper and Michael Alifrangis
Reference: 
Malaria Journal 2019 18:267, 3 September 2019

Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies.

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