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falciparum

Pandemic-related delay of falciparum malaria diagnosis in a traveler leading to cerebral malaria

October 16, 2021 - 19:58 -- Open Access
Author(s): 
Schubert L, Thurnher MM, Machold K, Tobudic S, Winkler S
Reference: 
J Travel Med. 2021 Oct 5:taab159

We report the case of a 29-year-old male in whom COVID-19 concerns led to a delayed diagnosis of falciparum malaria.

The global burden of Plasmodium vivax malaria is obscure and insidious

October 13, 2021 - 12:46 -- Open Access
Author(s): 
Battle KE, Baird JK
Reference: 
PLoS Med. 2021 Oct 7;18(10):e1003799

The global burden of malaria is often reported as a single value that combines the malarias caused by the 5 species of plasmodia that naturally infect humans. The vast majority of this burden is attributable to Plasmodium falciparum and Plasmodium vivax malarias, which have only recently begun to be reported separately in the World Malaria Report [2].

Spatial distribution of Plasmodium falciparum and P. vivax in northern Ethiopia by microscopy, rapid diagnostic test, laboratory antibody and antigen data

October 13, 2021 - 12:34 -- Open Access
Author(s): 
Leonard CM, Assefa A, Sime H, Mohammed H, Kebede A, Solomon H, Drakeley C, Murphy M, Hwang J, Rogier E
Reference: 
J Infect Dis. 2021 Oct 10:jiab489

Determining malaria transmission within regions of low, heterogenous prevalence is difficult. A variety of malaria tests exist and range from identification of diagnostic infection to testing for prior exposure. This study describes concordance of multiple malaria tests using data from a 2015 household survey conducted in Ethiopia.

Adaptation of ELISA detection of Plasmodium falciparum and Plasmodium vivax circumsporozoite proteins in mosquitoes to a multiplex bead-based immunoassay

October 6, 2021 - 20:11 -- Open Access
Author(s): 
Alice C. Sutcliffe, Seth R. Irish, Eric Rogier, Micaela Finney, Sarah Zohdy and Ellen M. Dotson
Reference: 
Malaria Journal 2021 20:377, 23 September 2021

Plasmodium spp. sporozoite rates in mosquitoes are used to better understand malaria transmission intensity, the relative importance of vector species and the impact of interventions. These rates are typically estimated using an enzyme-linked immunosorbent assay (ELISA) utilizing antibodies against the circumsporozoite protein of Plasmodium falciparum, Plasmodium vivax VK210 (P. vivax210) or P. vivax VK247 (P. vivax247), employing assays that were developed over three decades ago. The ELISA method requires a separate assay plate for each analyte tested and can be time consuming as well as requiring sample volumes not always available. The bead-based multiplex platform allows simultaneous measurement of multiple analytes and may improve the lower limit of detection for sporozoites.

Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis

September 25, 2021 - 12:06 -- Open Access
Author(s): 
Ketema T, Bacha K, Getahun K, Portillo HAD, Bassat Q
Reference: 
PLoS Negl Trop Dis. 2021 Sep 15;15(9):e0009781

Ethiopia is one of the scarce rare African countries where Plasmodium vivax and P. falciparum co-exist. There has been no attempt to derive a robust prevalence estimate of P. vivax in the country although a clear understanding of the epidemiology of this parasite is essential for informed decisions. This systematic review and meta-analysis, therefore, is aimed to synthesize the available evidences on the distribution of P. vivax infection by different locations/regions, study years, eco-epidemiological zones, and study settings in Ethiopia.

Not Open Access | A population genetic perspective on the origin, spread and adaptation of the human malaria agents Plasmodium falciparum and Plasmodium vivax

September 25, 2021 - 12:04 -- NOT Open Access
Author(s): 
Rougeron V, Boundenga L, Arnathau C, Durand P, Renaud F, Prugnolle F.
Reference: 
FEMS Microbiol Rev. 2021 Sep 22:fuab047

Malaria is considered one of the most important scourges that humanity has faced during its history, being responsible every year for numerous deaths worldwide. The disease is caused by protozoan parasites, among which two species are responsible of the majority of the burden, Plasmodium falciparum and Plasmodium vivax. For these two parasite species, the questions of their origin (how and when they appeared in humans), of their spread throughout the world, as well as how they have adapted to humans have long been of interest to the scientific community.

Identification of first-in-class plasmodium OTU inhibitors with potent anti-malarial activity

September 8, 2021 - 16:09 -- Open Access
Author(s): 
Siyah P, Akgol S, Durdagi S, Kocabas F
Reference: 
Biochem J. 2021 Sep 6:BCJ20210481

OTU proteases antagonize the cellular defense in the host cells and involve in pathogenesis. Intriguingly, P. falciparum, P. vivax, and P. yoelii have an uncharacterized and highly conserved viral OTU-like proteins. However, their structure, function or inhibitors have not been previously reported. To this end, we have performed structural modeling, small molecule screening, deconjugation assays to characterize and develop first-in-class inhibitors of P. falciparum, P. vivax, and P. yoelii OTU-like proteins.

Not Open Access | Degradation of endothelial glycocalyx in Tanzanian children with falciparum malaria

September 1, 2021 - 17:34 -- NOT Open Access
Author(s): 
Bush MA, Florence SM, Yeo TW, Kalingonji AR, Chen Y, Granger DL, Rubach MP, Anstey NM, Mwaikambo ED, Weinberg JB
Reference: 
FASEB J. 2021 Sep;35(9):e21805

A layer of glycocalyx covers the vascular endothelium serving important protective and homeostatic functions. The objective of this study was to determine if breakdown of the endothelial glycocalyx (eGC) occurs during malaria infection in children. Measures of eGC integrity, endothelial activation, and microvascular reactivity were prospectively evaluated in 146 children: 44 with moderately severe malaria (MSM), 42 with severe malaria (SM), and 60 healthy controls (HC).

Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities

September 1, 2021 - 16:27 -- Open Access
Author(s): 
Koepfli C, Nguitragool W, Mueller I, et al.
Reference: 
PLoS Negl Trop Dis. 2021 Aug 27;15(8):e0009672

Understanding epidemiological variables affecting gametocyte carriage and density is essential to design interventions that most effectively reduce malaria human-to-mosquito transmission.

Increased risk of severe malaria in travellers during the COVID-19 pandemic

September 1, 2021 - 15:56 -- Open Access
Author(s): 
de Laval F, Maugey N, Bonet d'Oléon A, Pommier de Santi V, Ficko C
Reference: 
J Travel Med. 2021 Aug 27;28(6):taab106

We observed an increase in severe cases of falciparum malaria among French service members (who are travellers in endemic areas) in 2020, associated with an increase in the time between onset of symptoms and diagnosis/treatment.

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