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falciparum

A patatin-like phospholipase functions during gametocyte induction in the malaria parasite Plasmodium falciparum

November 18, 2019 - 16:21 -- Open Access
Author(s): 
Flammersfeld A, Panyot A, Yamaryo-Botté Y, Aurass P, Przyborski JM, Flieger A, Botté C, Pradel G.
Reference: 
Cell Microbiol. 2019 Nov 16:e13146

Patatin-like phospholipases (PNPLAs) are highly conserved enzymes of prokaryotic and eukaryotic organisms with major roles in lipid homeostasis. The genome of the malaria parasite Plasmodium falciparum encodes four putative PNPLAs with predicted functions during phospholipid degradation.

Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review

September 10, 2019 - 15:34 -- Open Access
Author(s): 
Abel Kakuru, Sarah G. Staedke, Grant Dorsey, Stephen Rogerson and Daniel Chandramohan
Reference: 
Malaria Journal 2019 18:304, 3 September 2019

Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium falciparum malaria infection during pregnancy, and intermittent preventive treatment of malaria during pregnancy (IPTp), on the risk of clinical malaria or parasitaemia during infancy.

Methods

Applying next-generation sequencing to track falciparum malaria in sub-Saharan Africa

September 10, 2019 - 15:31 -- Open Access
Author(s): 
Sofonias K. Tessema, Jaishree Raman, Craig W. Duffy, Deus S. Ishengoma, Alfred Amambua-Ngwa and Bryan Greenhouse
Reference: 
Malaria Journal 2019 18:268, 3 September 2019

Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions.

Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities and challenges

September 10, 2019 - 15:29 -- Open Access
Author(s): 
Deus S. Ishengoma, Queen Saidi, Carol H. Sibley, Cally Roper and Michael Alifrangis
Reference: 
Malaria Journal 2019 18:267, 3 September 2019

Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies.

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

September 10, 2019 - 15:15 -- Open Access
Author(s): 
Eliud O. Odhiambo, Dibyadyuti Datta, Bernard Guyah, George Ayodo, Bartholomew N. Ondigo, Benard O. Abong’o, Chandy C. John and Anne E. P. Frosch
Reference: 
Malaria Journal 2019 18:297, 30 August 2019

HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody responses.

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NOT Open Access | Baseline Ex Vivo and Molecular Responses of Plasmodium falciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal

April 30, 2019 - 15:21 -- NOT Open Access
Author(s): 
Marie Gladys Robert, Francis Foguim Tsombeng, Mathieu Gendrot, Silman Diawara, Marylin Madamet, Mame Bou Kounta, Khalifa Ababacar Wade, Mansour Fall, Mamadou Wague Gueye, Nicolas Benoit, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Bécaye Fall, Boubacar Wade, Bakary Diatta and Bruno Pradines
Reference: 
Antimicrob. Agents Chemother. April 2019 63:e02445-18

Dihydroartemisinin-piperaquine, which was registered in 2017 in Senegal, is not currently used as the first-line treatment against uncomplicated malaria. A total of 6.6% to 17.1% of P. falciparum isolates collected in Dakar in 2013 to 2015 showed ex vivo-reduced susceptibility to piperaquine. 

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NOT Open Access | Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa

April 30, 2019 - 15:18 -- NOT Open Access
Author(s): 
Chao Xu, Hui Sun, Qingkuan Wei, Jin Li, Ting Xiao, Xiangli Kong, Yongbin Wang, Guihua Zhao, Longjiang Wang, Gongzhen Liu, Ge Yan, Bingcheng Huang and Kun Yin
Reference: 
Antimicrob. Agents Chemother. April 2019 63:e01927-18

We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016.

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NOT Open Access | Identification of Antimalarial Compounds That Require CLAG3 for Their Uptake by Plasmodium falciparum-Infected Erythrocytes

April 30, 2019 - 15:17 -- NOT Open Access
Author(s): 
Sofía Mira-Martínez, Anastasia K. Pickford, Núria Rovira-Graells, Pieter Guetens, Elisabet Tintó-Font, Alfred Cortés and Anna Rosanas-Urgell
Reference: 
Antimicrob. Agents Chemother. April 2019 63:e00052-19

During the intraerythrocytic asexual cycle malaria parasites acquire nutrients and other solutes through a broad selectivity channel localized at the membrane of the infected erythrocyte termed the plasmodial surface anion channel (PSAC). The protein product of the Plasmodium falciparum clonally variant clag3.1 and clag3.2 genes determines PSAC activity. Switches in the expression of clag3 genes, which are regulated by epigenetic mechanisms, are associated with changes in PSAC-dependent permeability that can result in resistance to compounds toxic for the parasite, such as blasticidin S. Here, we investigated whether other antimalarial drugs require CLAG3 to reach their intracellular target and consequently are prone to parasite resistance by epigenetic mechanisms. 

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Antibodies to Peptides in Semiconserved Domains of RIFINs and STEVORs Correlate with Malaria Exposure

April 30, 2019 - 15:03 -- Open Access
Author(s): 
Albert E. Zhou, Andrea A. Berry, Mark A. Travassos, et al.
Reference: 
mSphere March/April 2019 4:e00097-19

The repetitive interspersed family (RIFIN) and the subtelomeric variable open reading frame (STEVOR) family represent two of three major Plasmodium falciparum variant surface antigen families involved in malaria pathogenesis and immune evasion and are potential targets in the development of natural immunity. Protein and peptide microarrays populated with RIFINs and STEVORs associated with severe malaria vulnerability in Malian children were probed with adult and pediatric sera to identify epitopes that reflect malaria exposure.

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Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi

April 29, 2019 - 13:13 -- Open Access
Author(s): 
Sakineh Pirahmadi, Sedigheh Zakeri, Akram A. Mehrizi, Navid D. Djadid, Abbas-Ali Raz, Jafar J. Sani, Ronak Abbasi and Zahra Ghorbanzadeh
Reference: 
Malaria Journal 2019 18:146, 24 April 2019

Plasmodium falciparum parasite is the most deadly species of human malaria, and the development of an effective vaccine that prevents P. falciparum infection and transmission is a key target for malarial elimination and eradication programmes. P. falciparum cell-traversal protein for ookinetes and sporozoites (PfCelTOS) is an advanced vaccine candidate. A comparative study was performed to characterize the immune responses in BALB/c mouse immunized with Escherichia coli-expressed recombinant PfCelTOS (rPfCelTOS) in toll-like receptor (TLR)-based adjuvants, CpG and Poly I:C alone or in combination (CpG + Poly I:C), followed by the assessment of transmission-reducing activity (TRA) of anti-rPfCelTOS antibodies obtained from different vaccine groups in Anopheles stephensi.

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