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NOT Open Access | Occurrence and Distribution of Non-falciparum Malaria Parasite Species among Adolescents and Adults in Malawi

July 14, 2021 - 10:39 -- NOT Open Access
Gumbo A, Topazian HM, Juliano JJ, et al.
J Infect Dis. 2021 Jul 9:jiab353

Plasmodium falciparum malaria dominates throughout sub-Saharan Africa, but the prevalence of P. malariae, P. ovale spp., and P. vivax increasingly contribute to infection in countries which control malaria using P. falciparum-specific diagnostic and treatment strategies.

Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites

July 13, 2021 - 14:54 -- Open Access
Kolli SK, Salman AM, Janse CJ, et al.
PLoS One. 2021 Jul 12;16(7):e0254498

To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages, fourteen P. falciparum proteins were selected based on expression in sporozoites or their role in establishment of hepatocyte infection. For preclinical evaluation of immunogenicity of these proteins in mice, chimeric P. berghei sporozoites were created that express the P. falciparum proteins in sporozoites as an additional copy gene under control of the uis4 gene promoter.

A Severe Case of Falciparum Malaria, 10 Years After Malaria Eradication: A Case Report

July 7, 2021 - 15:05 -- Open Access
Abdullah SJ, Abdulateef DS, Rahman HS, Mahmood SO, Mustafa VN, Ahmed RO, Ahmed RA
Yale J Biol Med. 2021 Jun 30;94(2):277-284

Malaria is a major mosquito-borne public health problem especially in tropical countries. The authors report a malaria infection in a 31-year-old man who had returned from East Africa with developed fever and rigor. Because of his thrombocytopenia, decreased hemoglobin, elevated liver enzymes, and splenomegaly, and because of failure to question about recent travel history, he was initially referred to the hematological hospital and medical staff suspected a hematological problem, so he was investigated for bone marrow aspirate and biopsy.

A comparative study of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) blood levels and peripheral blood parasitemia as parameters of disease severity in individuals with imported falciparum malaria

July 6, 2021 - 14:35 -- Open Access
Kwak JD, Young JJ, Stuij AC, Koelewijn R, van Hellemond JJ, van Genderen PJJ. Travel
Med Infect Dis. 2021 Jul-Aug;42:102076

In falciparum malaria the total parasite biomass can be estimated by blood levels of histidine-rich protein 2 (PfHRP2), a Plasmodium falciparum-specific protein, which has been widely studied in malaria-endemic regions. This study investigates the usefulness of PfHRP2 as marker for disease severity in imported falciparum malaria.

Malaria prevalence, knowledge, attitude, and practice among febrile patients attending Chagni health center, Northwest Ethiopia: a cross-sectional study

July 6, 2021 - 14:32 -- Open Access
Belay B, Gelana T, Gebresilassie A
Trop Dis Travel Med Vaccines. 2021 Jul 5;7(1):20

Ethiopia has achieved considerable progresses in the prevention and control of malaria in the past decades; hitherto it is a formidable health concern and socio-economic impediment. This study aimed at assessing the magnitude, knowledge, attitudes and practices towards malaria among febrile patients attending Chagni health center, northwest Ethiopia.

NOT Open Access | Advanced Lyophilised Loop Mediated Isothermal Amplification (L-LAMP) based point of care technique for the detection of dengue virus

July 6, 2021 - 13:51 -- NOT Open Access
Sandeep Kumar, Supriya Sharma, Nitin Bhardwaj, Veena Pande, Deepali Savargaonkar and Anupkumar R.Anvikar
J Virol Methods. 2021 Jul;293:114168

Dengue virus infects millions of the people globally each year and its diagnosis remains a challenge. Conventionally used diagnostic methods are complex and time consuming. LAMP technique is a potential alternative for diagnosis of dengue virus. The benefits of LAMP are its ease and ability, as it does not require an expensive equipment and results are effortlessly visualized by the naked eye. However, it does not aid as point of care technique owing to need of contamination free area, deep freezer for chemical storage and primer self amplification.

Plasmodium vivax pre-erythrocytic vaccines

June 30, 2021 - 12:55 -- Open Access
Reyes-Sandoval A
Parasitol Int. 2021 Jun 21;84:102411

An estimated 229 million cases of malaria occurred worldwide in 2019. Both, Plasmodium falciparum and P. vivax are responsible for most of the malaria disease burden in the world. Despite difficulties in obtaining an accurate number, the global estimates of cases in 2019 are approximately 229 million of which 2.8% are due to P. vivax, and the total number of malaria deaths are approximately 409 million.

Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial

June 30, 2021 - 12:20 -- Open Access
Grace Mzumara, Stije Leopold, Kevin Marsh, Arjen Dondorp, Eric O. Ohuma and Mavuto Mukaka
Malaria Journal 2021 20:282, 25 June 2021

Severe metabolic acidosis and acute kidney injury are major causes of mortality in children with severe malaria but are often underdiagnosed in low resource settings.

NOT Open Access | Structural analyses of the malaria parasite aminoacyl-tRNA synthetases provide new avenues for antimalarial drug discovery

June 30, 2021 - 11:28 -- NOT Open Access
Chhibber-Goel J, Yogavel M, Sharma A
Protein Sci. 2021 Jun 28

Malaria is a parasitic illness caused by the genus Plasmodium from the apicomplexan phylum. Five plasmodial species of P. falciparum, P. knowlesi, P. malariae, P. ovale and P. vivax are responsible for causing malaria in humans. According to the World Malaria Report 2019, there were 229 million cases and ~ 0.04 million deaths of which 67% were in children below five years of age.

Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria

June 29, 2021 - 14:18 -- Open Access
Dini S, Zaloumis SG, Price DJ, Gobeau N, Kümmel A, Cherkaoui M, Moehrle JJ, McCarthy JS, Simpson JA
J Antimicrob Chemother. 2021 Jun 28:dkab181

The efficacy of artemisinin-based combination therapies (ACTs), the first-line treatments for uncomplicated falciparum malaria, has been declining in malaria-endemic countries due to the emergence of malaria parasites resistant to these compounds. Novel alternative therapies are needed urgently to prevent the likely surge in morbidity and mortality due to failing ACTs.


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