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Re-introduction of vivax malaria in a temperate area (Moscow region, Russia): a geographic investigation

March 23, 2020 - 11:37 -- Open Access
Varvara A. Mironova, Natalia V. Shartova, Andrei E. Beljaev, Mikhail I. Varentsov, Fedor I. Korennoy and Mikhail Y. Grishchenko
Malaria Journal 2020 19:116, 18 March 2020

Between 1999 and 2008 Russia experienced a flare-up of transmission of vivax malaria following its massive importation with more than 500 autochthonous cases in European Russia, the Moscow region being the most affected. The outbreak waned soon after a decrease in importation in mid-2000s and strengthening the control measures. Compared with other post-eradication epidemics in Europe this one was unprecedented by its extension and duration.

NOT Open Access | Capture and Detection of Plasmodium vivax Lactate Dehydrogenase in a Bead-Based Multiplex Immunoassay

March 9, 2020 - 14:30 -- NOT Open Access
Rogier E, Nace D, Ljolje D, Lucchi NW, Udhayakumar V, Aidoo M
Am J Trop Med Hyg. 2020 Mar 2

Laboratory detection of malaria antigens has proved valuable for research and epidemiological purposes. We recently developed a bead-based multiplex antigen assay for pan-Plasmodium and Plasmodium falciparum targets. Here, we report integration of a Plasmodium vivax–specific target to this multiplex panel: P. vivax lactate dehydrogenase (PvLDH).

NOT Open Access | Early endothelial activation precedes glycocalyx degradation and microvascular dysfunction in experimentally induced Plasmodium falciparum and Plasmodium vivax infection

March 9, 2020 - 14:24 -- NOT Open Access
Woodford J, Yeo TW, Piera KA, Butler K, Weinberg JB, McCarthy JS, Anstey NM, Barber BE
Infect Immun. 2020 Mar 2. pii: IAI.00895-19

Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced P. falciparum and P. vivax infection.

Vivax malaria in pregnancy and lactation: a long way to health equity

January 27, 2020 - 13:30 -- Open Access
Tobias Brummaier, Mary Ellen Gilder, Gornpan Gornsawun, Cindy S. Chu, Germana Bancone, Mupawjay Pimanpanarak, Kesinee Chotivanich, François Nosten and Rose McGready
Malaria Journal 2020 19:40, 22 January 2020

The Sustainable Development Goals (SDG) call for increased gender equity and reduction in malaria-related mortality and morbidity. Plasmodium vivax infections in pregnancy are associated with maternal anaemia and increased adverse perinatal outcomes. Providing radical cure for women with 8-aminoquinolines (e.g., primaquine) is hindered by gender-specific complexities.

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

December 23, 2019 - 14:55 -- Open Access
de Jong RM, Tebeje SK, Meerstein-Kessel L, Tadesse FG, Jore MM, Stone W, Bousema T
Immunol Rev. 2019 Dec 16.

The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to mosquitoes. Here, we summarize evidence for naturally acquired anti‐gametocyte immunity and the current state of transmission blocking vaccines (TBV). Although gametocytes are intra‐erythrocytic when present in infected humans, developing Plasmodium falciparum gametocytes may express proteins on the surface of red blood cells that elicit immune responses in naturally exposed individuals.

Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria

October 27, 2014 - 16:38 -- Open Access
Henry Kajumbula, Wilson Byarugaba and Misaki Wayengera
Genetic Vaccines and Therapy 2012, 10:8

We hypothesized that artificial aberration of the host-pathway by target mutagenesis of either RBC –receptors, may abolish or reduce susceptibility of the host to malaria. As a first step towards the experimental actualization of these concepts, we aimed to identify zinc finger arrays (ZFAs) for constructing ZFNs that target genes of either wild-type host-RBC- receptors.

Column: Vivax malaria, breaking the cycle of endless suffering - by George Jagoe

July 10, 2014 - 10:56 -- Ingeborg van Schayk
"And I saw Sisyphus at his endless task raising his prodigious stone with both his hands. With hands and feet he tried to roll it up to the top of the hill, but just before he could roll it over the other side, its weight would be too much for him, and the pitiless stone would come thundering down again on to the plain. Then he would begin trying to push it up hill again, and the sweat ran off him and the steam rose after him."
The Odyssey of Homer, translated by Samuel Butler

NOT Open Access | A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

July 31, 2013 - 09:35 -- NOT Open Access
Sandra March, Shengyong Ng, Sangeeta N. Bhatia, et al.
Cell Host & Microbe, Volume 14, Issue 1, 104-115, 17

The Plasmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage.

Medical Treatment: 

Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria

June 24, 2013 - 15:24 -- Open Access
Taylor WR, Widjaja H, Basri H, Tjitra E, Ohrt C, Taufik T, Baso S, Hoffman SL, Richie TL
Malaria Journal 2013, 12:209 (19 June 2013)

Haemoglobin recovery was related to baseline Hb. Vivax-infected malaria immune Papuans had persistently lower Hb concentrations compared to non-Papuans with limited malaria exposure. This haematological disadvantage remains unexplained.


Event: iVAX Fellowship for Investigators from Malaria Endemic Countries

April 4, 2013 - 21:03 -- MalariaWorld Events

15 travel fellowships will be awarded to scientists from malaria endemic countries that submit an abstract for the “Advances in Plasmodium vivax Malaria Research” conference, 28-30 May 2013 in Barcelona Spain.

The deadline for submission of applications is April 12, 2013.


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