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Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria

October 27, 2014 - 16:38 -- Open Access
Henry Kajumbula, Wilson Byarugaba and Misaki Wayengera
Genetic Vaccines and Therapy 2012, 10:8

We hypothesized that artificial aberration of the host-pathway by target mutagenesis of either RBC –receptors, may abolish or reduce susceptibility of the host to malaria. As a first step towards the experimental actualization of these concepts, we aimed to identify zinc finger arrays (ZFAs) for constructing ZFNs that target genes of either wild-type host-RBC- receptors.

Column: Vivax malaria, breaking the cycle of endless suffering - by George Jagoe

July 10, 2014 - 10:56 -- Ingeborg van Schayk
"And I saw Sisyphus at his endless task raising his prodigious stone with both his hands. With hands and feet he tried to roll it up to the top of the hill, but just before he could roll it over the other side, its weight would be too much for him, and the pitiless stone would come thundering down again on to the plain. Then he would begin trying to push it up hill again, and the sweat ran off him and the steam rose after him."
The Odyssey of Homer, translated by Samuel Butler

NOT Open Access | A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

July 31, 2013 - 09:35 -- NOT Open Access
Sandra March, Shengyong Ng, Sangeeta N. Bhatia, et al.
Cell Host & Microbe, Volume 14, Issue 1, 104-115, 17

The Plasmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage.

Medical Treatment: 

Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria

June 24, 2013 - 15:24 -- Open Access
Taylor WR, Widjaja H, Basri H, Tjitra E, Ohrt C, Taufik T, Baso S, Hoffman SL, Richie TL
Malaria Journal 2013, 12:209 (19 June 2013)

Haemoglobin recovery was related to baseline Hb. Vivax-infected malaria immune Papuans had persistently lower Hb concentrations compared to non-Papuans with limited malaria exposure. This haematological disadvantage remains unexplained.


Event: iVAX Fellowship for Investigators from Malaria Endemic Countries

April 4, 2013 - 21:03 -- MalariaWorld Events

15 travel fellowships will be awarded to scientists from malaria endemic countries that submit an abstract for the “Advances in Plasmodium vivax Malaria Research” conference, 28-30 May 2013 in Barcelona Spain.

The deadline for submission of applications is April 12, 2013.

Event: Advances in Plasmodium vivax Malaria Research & Assessing the Plasmodium vivax Research Agenda: Interdisciplinary Workshops

March 14, 2013 - 18:00 -- MalariaWorld Events


Date: 28-30 May 2013

Hour: 8am – 6pm

Venue: CosmoCaixa, Barcelona, Spain


Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi

January 13, 2013 - 13:40 -- Open Access
Barber BE, William T, Grigg MJ, Yeo TW, Anstey NM
Malaria Journal 2013, 12:8 (8 January 2013)

This prospective study in Sabah, Malaysia, evaluated the accuracy of routine district and referral hospital-based microscopy, and microscopy performed by an experienced research microscopist, for the diagnosis of PCR-confirmed Plasmodium falciparum, P. knowlesi, and Plasmodium vivax malaria.

NOT Open Access | Plasmodium vivax and Plasmodium knowlesi: Cloning, expression and functional analysis of 1-Cys peroxiredoxin

January 4, 2013 - 14:25 -- NOT Open Access
Hassan Hakimi, Masahito Asada, Jose Ma. M. Angeles, Satoru Kawai, Noboru Inoue, Shin-ichiro Kawazu
Experimental Parasitology, Volume 133, Issue 1, January 2013, Pages 101–105

Malaria parasites like other aerobes need to detoxify the reactive oxygen species (ROS) that are mainly produced from hemoglobin degradation in the food vacuole.

Evaluation of the OnSite (Pf/Pan) rapid diagnostic test for diagnosis of clinical malaria

December 19, 2012 - 06:15 -- Open Access
Mohon A, Elahi R, Podder M, Mohiuddin K, Hossain M, Khan WA, Haque R, Alam M
Malaria Journal 2012, 11:415 (12 December 2012)

The new OnSite (Pf/Pan) RDT is both sensitive and specific for symptomatic malaria diagnosis in standard laboratory conditions.

Medical Treatment: 


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