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vivax

Absence of gender influence on the pharmacokinetics of chloroquine combined with primaquine in malaria vivax patients

November 7, 2020 - 12:25 -- Open Access
Author(s): 
Vieira MVDF, Mello AGCN, Sena LWP, Vieira JLF
Reference: 
Rev Inst Med Trop Sao Paulo. 2020 Oct 30;62:e83

Chloroquine is the first-line therapy against the asexual stages of Plasmodium vivax . There is a high variation of chloroquine plasma levels after therapeutic doses, which can lead to inadequate exposure to the drug. The gender influence was low regarding the disposition of the drug, which is relevant as there are significant physiological variations between male and female patients.

Malaria in Sundargarh district, Odisha, India: Epidemiological and behavioral aspects from surveys

November 4, 2020 - 15:57 -- Open Access
Author(s): 
van Eijk AM, Choubey S, Barla P, Haque MA, Nandini P, Acharya S, Sullivan SA, Mohanty S, Satpathi S, Carlton JM
Reference: 
Acta Trop. 2020 Nov;211:105647. doi: 10.1016/j.actatropica

To characterize malaria and assist in prevention efforts, we conducted a series of epidemiological studies in Sundargarh district, India, as part of an NIH-funded International Center of Excellence for Malaria Research. In a published survey around Rourkela in 2013-2014 (N = 1307), malaria prevalence was found to be 8.3%. Using these data, villages were divided into low (<2%), medium (2-10%) and high (>10%) malaria prevalence, and risk factors assessed by type of village. In the six low malaria villages, four persons were positive by PCR; in the four medium malaria villages, prevalence was 7% (35 infections, 7 P. vivax); and in the three high malaria villages, prevalence was 21% (62 infections, 10 P. vivax and 5 mixed with P. vivax and P. falciparum).

Severe vivax malaria trends in the last two years: a study from a tertiary care centre, Delhi, India

November 4, 2020 - 09:53 -- Open Access
Author(s): 
Matlani M, Kojom LP, Mishra N, Dogra V, Singh V
Reference: 
Ann Clin Microbiol Antimicrob. 2020 Oct 30;19(1):49

Plasmodium vivax, once considered benign species, is recently being recognised to be causing severe malaria like Plasmodium falciparum. In the present study, the authors report the trends in malaria severity in P. vivax among patients from a Delhi government hospital. The aim of the study was to understand the disease severity and the burden of severe vivax malaria.

Acquired antibody responses against merozoite surface protein-1(19) antigen during Plasmodium falciparum and P.vivax infections in South Indian city of Mangaluru

October 31, 2020 - 09:30 -- Open Access
Author(s): 
Punnath K, Dayanand KK, Midya V, Chandrashekar VN, Achur RN, Kakkilaya SB, Ghosh SK, Kumari SN, Gowda DC
Reference: 
J Parasit Dis. 2020 Oct 21:1-1

Merozoite surface protein-1 (MSP-1) of malaria parasites has been extensively studied as a malaria vaccine candidate and the antibody response to this protein is an important indicator of protective immunity to malaria. Mangaluru city and its surrounding areas in southwestern India are endemic to malaria with Plasmodium vivax being the most widespread and prevalent species although P. falciparum also frequently infects.

Factors associated with malaria in indigenous populations: A retrospective study from 2007 to 2016

October 22, 2020 - 15:54 -- Open Access
Author(s): 
Meireles BM, de Souza Sampaio V, Monteiro WM, Gonçalves MJF
Reference: 
PLoS One. 2020 Oct 21;15(10):e0240741

In Brazil malaria is most frequent in the Amazon region, mainly in the Amazonas state, where it is found the most proportion of indigenous people of the whole country. It is remarkable publications about malaria in the Amazon, although information on malaria in indigenous populations is still poorly explored.

Evaluation of the malaria reporting system supported by the District Health Information System 2 in Solomon Islands

October 20, 2020 - 16:26 -- Open Access
Author(s): 
Kinley Wangdi, Haribondu Sarma, John Leaburi, Emma McBryde and Archie C. A. Clements
Reference: 
Malaria Journal 2020 19:372, 17 October 2020

District Health Information Systems 2 (DHIS2) is used for supporting health information management in 67 countries, including Solomon Islands. However, there have been few published evaluations of the performance of DHIS2-enhanced disease reporting systems, in particular for monitoring infectious diseases such as malaria. The aim of this study was to evaluate DHIS2 supported malaria reporting in Solomon Islands and to develop recommendations for improving the system.

Analysis of Plasmodium vivax schizont transcriptomes from field isolates reveals heterogeneity of expression of genes involved in host-parasite interactions

October 8, 2020 - 15:31 -- Open Access
Author(s): 
Siegel SV, Chappell L, Hostetler JB, Amaratunga C, Suon S, Böhme U, Berriman M, Fairhurst RM, Rayner JC
Reference: 
Sci Rep. 2020 Oct 7;10(1):16667

Plasmodium vivax gene regulation remains difficult to study due to the lack of a robust in vitro culture method, low parasite densities in peripheral circulation and asynchronous parasite development. We adapted an RNA-seq protocol "DAFT-seq" to sequence the transcriptome of four P. vivax field isolates that were cultured for a short period ex vivo before using a density gradient for schizont enrichment.

Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname

October 8, 2020 - 15:21 -- Open Access
Author(s): 
Mergiory Y. Labadie-Bracho, Farah T. van Genderen and Malti R. Adhin
Reference: 
Malaria Journal 2020 19:360, 8 October 2020

Suriname has accomplished a steep decline in malaria burden, even reaching elimination levels. Plasmodium serology data are not available for Suriname and even extremely scarce within the region, therefore malaria serology testing was introduced, country customized cut-off values were determined and a study was performed to explore the antibody status for Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae.

Not Open Access | Monitoring Plasmodium falciparum and Plasmodium vivax using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea

September 30, 2020 - 11:46 -- NOT Open Access
Author(s): 
Kattenberg JH, Razook Z, Barry AE, et al.
Reference: 
Mol Ecol. 2020 Sep 28

Monitoring the genetic structure of pathogen populations may be an economical and sensitive approach to quantify the impact of control on transmission dynamics, highlighting the need for a better understanding of changes in population genetic parameters as transmission declines. Here we describe the first population genetic analysis of the major human malaria parasites, Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) following nationwide distribution of long-lasting insecticide treated nets (LLIN) in Papua New Guinea (PNG).

Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests

September 24, 2020 - 08:07 -- Open Access
Author(s): 
André Barembaye Sagna, Mohammad Golam Kibria, Shamsun Naher, Shayla Islam, M. M. Aktaruzzaman, Mohammad Shafiul Alam and Cristian Koepfli
Reference: 
Malaria Journal 2020 19:345, 23 September 2020

Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests (RDTs), used by national malaria control and elimination programs for clinical diagnosis, present a valuable, yet rarely used resource for in-depth studies on malaria epidemiology.

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