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vivax

NOT Open Access | A Cluster of Cryptic Plasmodium falciparum Malaria in African Migrants in Southern Italy, October 2017

August 25, 2020 - 15:22 -- NOT Open Access
Author(s): 
Brindicci G, Santoro CR, Loconsole D, Martinelli D, Prato R, Lonero G, Loperfido P, Buccoliero GB, Chironna M
Reference: 
Vector Borne Zoonotic Dis. 2020 Aug 20

Italy was declared malaria free by the World Health Organization in 1970. Despite this, nonimport malaria cases are on the increase in Italy and throughout the Mediterranean area. In Italy, in the period between 2011 and 2015, seven cases of locally acquired malaria have been reported, including one introduced case of Plasmodium vivax; moreover, the last certain case of introduced malaria (by P. vivax) has been reported in Tuscany in 1997. No case of introduced malaria from Plasmodium falciparum has been reported in Italy since 1970.

Not Open Access | Temporal and micro-spatial heterogeneity in transmission dynamics of co-endemic Plasmodium vivax and Plasmodium falciparum in two rural cohort populations in the Peruvian Amazon

August 25, 2020 - 07:59 -- NOT Open Access
Author(s): 
Rosas-Aguirre A, Guzman-Guzman M, Llanos-Cuentas A, et al.
Reference: 
J Infect Dis. 2020 Aug 21:jiaa526

Malaria is highly heterogeneous; its changing malaria micro-epidemiology needs to be addressed to support malaria elimination efforts at the regional level.

Detection of remaining Plasmodium DNA and gametocytes during follow up after curative malaria treatment among returned travellers in Norway

August 19, 2020 - 16:07 -- Open Access
Author(s): 
Christel Gill Haanshuus and Kristine Mørch
Reference: 
Malaria Journal 2020 19:296, 19 August 2020

PCR can be positive weeks after effective malaria treatment, potentially leading to over diagnose of recrudescence and re-infections. The DNA detected by PCR post-treatment might stem from residuals of destroyed asexual parasites, or from live gametocytes. The objective of this clinical observational study was to describe the presence of positive PCR for Plasmodium falciparum and Plasmodium vivax in follow-up samples post-treatment from returned travellers, and the proportion of positive PCR due to gametocytes.

The characterization of extracellular vesicles-derived microRNAs in Thai malaria patients

August 11, 2020 - 13:52 -- Open Access
Author(s): 
Nutpakal Ketprasit, Iris Simone Cheng, Fiona Deutsch, Nham Tran, Mallika Imwong, Valery Combes and Duangdao Palasuwan
Reference: 
Malaria Journal 2020 19:285, 10 August 2020

Extracellular vesicles (EVs) have been broadly studied in malaria for nearly a decade. These vesicles carry various functional biomolecules including RNA families such as microRNAs (miRNA). These EVs-derived microRNAs have numerous roles in host-parasite interactions and are considered promising biomarkers for disease severity. However, this field lacks clinical studies of malaria-infected samples. In this study, EV specific miRNAs were isolated from the plasma of patients from Thailand infected with Plasmodium vivax and Plasmodium falciparum. In addition, it is postulated that these miRNAs were differentially expressed in these groups of patients and had a role in disease onset through the regulation of specific target genes.

Spatial and Temporal Patterns of Malaria in Phu Yen Province, Vietnam, from 2005 to 2016

August 5, 2020 - 16:09 -- Open Access
Author(s): 
Wangdi K, Canavati S, Duc TN, Nguyen TM, Tran LK, Kelly GC, Martin NJ, Clements ACA
Reference: 
J Trop Med Hyg. 2020 Aug 3

Malaria in Vietnam has become focal to a few provinces, including Phu Yen. This study aimed to assess correlations between intervention (population proportion protected by insecticide-treated nets and indoor residual spraying) and climatic variables with malaria incidence in Phu Yen Province. The Vietnam National Institute of Malariology, Parasitology, and Entomology provided incidence data for Plasmodium falciparum and Plasmodium vivax for 104 communes of Phu Yen Province from January 2005 to December 2016.

Association between the proportion of Plasmodium falciparum and Plasmodium vivax infections detected by passive surveillance and the magnitude of the asymptomatic reservoir in the community: a pooled analysis of paired health facility and community data

August 3, 2020 - 15:54 -- Open Access
Author(s): 
Stresman G, Sepúlveda N, Fornace K, et al.
Reference: 
Lancet Infect Dis. 2020 Aug;20(8):953-963

Passively collected malaria case data are the foundation for public health decision making. However, because of population-level immunity, infections might not always be sufficiently symptomatic to prompt individuals to seek care. Understanding the proportion of all Plasmodium spp infections expected to be detected by the health system becomes particularly paramount in elimination settings. The aim of this study was to determine the association between the proportion of infections detected and transmission intensity for Plasmodium falciparum and Plasmodium vivax in several global endemic settings.

Hotspots in Plasmodium and RBC Receptor-Ligand Interactions: Key Pieces for Inhibiting Malarial Parasite Invasion

July 7, 2020 - 13:48 -- Open Access
Author(s): 
Patarroyo MA, Molina-Franky J, Gómez M, Arévalo-Pinzón G, Patarroyo ME
Reference: 
Int J Mol Sci. 2020 Jul 2;21(13):E4729

Protein-protein interactions (IPP) play an essential role in practically all biological processes, including those related to microorganism invasion of their host cells. It has been found that a broad repertoire of receptor-ligand interactions takes place in the binding interphase with host cells in malaria, these being vital interactions for successful parasite invasion. Several trials have been conducted for elucidating the molecular interface of interactions between some Plasmodium falciparum and Plasmodium vivax antigens with receptors on erythrocytes and/or reticulocytes.

Re-introduction of vivax malaria in a temperate area (Moscow region, Russia): a geographic investigation

March 23, 2020 - 11:37 -- Open Access
Author(s): 
Varvara A. Mironova, Natalia V. Shartova, Andrei E. Beljaev, Mikhail I. Varentsov, Fedor I. Korennoy and Mikhail Y. Grishchenko
Reference: 
Malaria Journal 2020 19:116, 18 March 2020

Between 1999 and 2008 Russia experienced a flare-up of transmission of vivax malaria following its massive importation with more than 500 autochthonous cases in European Russia, the Moscow region being the most affected. The outbreak waned soon after a decrease in importation in mid-2000s and strengthening the control measures. Compared with other post-eradication epidemics in Europe this one was unprecedented by its extension and duration.

NOT Open Access | Capture and Detection of Plasmodium vivax Lactate Dehydrogenase in a Bead-Based Multiplex Immunoassay

March 9, 2020 - 14:30 -- NOT Open Access
Author(s): 
Rogier E, Nace D, Ljolje D, Lucchi NW, Udhayakumar V, Aidoo M
Reference: 
Am J Trop Med Hyg. 2020 Mar 2

Laboratory detection of malaria antigens has proved valuable for research and epidemiological purposes. We recently developed a bead-based multiplex antigen assay for pan-Plasmodium and Plasmodium falciparum targets. Here, we report integration of a Plasmodium vivax–specific target to this multiplex panel: P. vivax lactate dehydrogenase (PvLDH).

NOT Open Access | Early endothelial activation precedes glycocalyx degradation and microvascular dysfunction in experimentally induced Plasmodium falciparum and Plasmodium vivax infection

March 9, 2020 - 14:24 -- NOT Open Access
Author(s): 
Woodford J, Yeo TW, Piera KA, Butler K, Weinberg JB, McCarthy JS, Anstey NM, Barber BE
Reference: 
Infect Immun. 2020 Mar 2. pii: IAI.00895-19

Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced P. falciparum and P. vivax infection.

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