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Distribution pattern of amino acid mutations in chloroquine and antifolate drug resistance associated genes in complicated and uncomplicated Plasmodium vivax isolates from Chandigarh, North India

September 16, 2020 - 13:09 -- Open Access
Kaur H, Sehgal R, Kumar A, Bharti PK, Bansal D, Mohapatra PK, Mahanta J, Sultan AA
BMC Infect Dis. 2020 Sep 15;20(1):671

The increasing antimalarial drug resistance is a significant hindrance to malaria control and elimination programs. For the last six decades, chloroquine (CQ) plus pyrimethamine remains the first-line treatment for P. vivax malaria. Regions where both P. falciparum and P. vivax co-exist, P. vivax is exposed to antifolate drugs due to either misdiagnosis or improper treatment that causes selective drug pressure to evolve. Therefore, the present study aims to estimate antimalarial drug resistance among the complicated and uncomplicated P. vivax patients.

NOT Open Access | Climate based malaria forecasting system for Andhra Pradesh, India

September 5, 2020 - 15:51 -- NOT Open Access
Mopuri R, Kakarla SG, Mutheneni SR, Kadiri MR, Kumaraswamy S
J Parasit Dis. 2020 Sep;44(3):497-510

Malaria is a major public health problem in tropical and subtropical countries of the World. During the year 1999, Visakhapatnam district of Andhra Pradesh, India experienced a major epidemic of malaria, and nearly 41,805 cases were reported. Hence, a retrospective malaria surveillance study was conducted from 2001 to 2016 and reported nearly a total of 149,317 malaria cases during the study period.

NOT Open Access | Comparision of the various routine diagnostic modalities of malaria and a new method: the Parasight™ platform

September 5, 2020 - 15:49 -- NOT Open Access
Das S, Rajkumari N, Revathi U, Gururajan A
J Parasit Dis. 2020 Sep;44(3):528-535

Malaria is one of most important parasitic disease, which is still much prevalent in India. The burden of malaria in India is complex and the proportions of Plasmodium vivax and Plasmodium falciparum vary across India, because of the highly variable malaria eco-epidemiological profiles, transmission factors, and the presence of multiple Plasmodium species and Anopheles vectors.

Utility of ultra-sensitive qPCR to detect Plasmodium falciparum and Plasmodium vivax infections under different transmission intensities

September 5, 2020 - 14:51 -- Open Access
Maria Gruenberg, Clara Antunes Moniz, Ingrid Felger, et al.
Malaria Journal 2020 19:319, 3 September 2020

The use of molecular diagnostics has revealed an unexpectedly large number of asymptomatic low-density malaria infections in many malaria endemic areas. This study compared the gains in parasite prevalence obtained by the use of ultra-sensitive (us)-qPCR as compared to standard qPCR in cross-sectional surveys conducted in Thailand, Brazil and Papua New Guinea (PNG). The compared assays differed in the copy number of qPCR targets in the parasite genome.

Differential contribution of Anopheles coustani and Anopheles arabiensis to the transmission of Plasmodium falciparum and Plasmodium vivax in two neighbouring villages of Madagascar

August 27, 2020 - 08:17 -- Open Access
Goupeyou-Youmsi J, Rakotondranaivo T, Puchot N, Peterson I, Girod R, Vigan-Womas I, Paul R, Ndiath MO, Bourgouin C
Parasit Vectors. 2020 Aug 26;13(1):430

Malaria is still a heavy public health concern in Madagascar. Few studies combining parasitology and entomology have been conducted despite the need for accurate information to design effective vector control measures. In a Malagasy region of moderate to intense transmission of both Plasmodium falciparum and P. vivax, parasitology and entomology have been combined to survey malaria transmission in two nearby villages.

NOT Open Access | A Cluster of Cryptic Plasmodium falciparum Malaria in African Migrants in Southern Italy, October 2017

August 25, 2020 - 15:22 -- NOT Open Access
Brindicci G, Santoro CR, Loconsole D, Martinelli D, Prato R, Lonero G, Loperfido P, Buccoliero GB, Chironna M
Vector Borne Zoonotic Dis. 2020 Aug 20

Italy was declared malaria free by the World Health Organization in 1970. Despite this, nonimport malaria cases are on the increase in Italy and throughout the Mediterranean area. In Italy, in the period between 2011 and 2015, seven cases of locally acquired malaria have been reported, including one introduced case of Plasmodium vivax; moreover, the last certain case of introduced malaria (by P. vivax) has been reported in Tuscany in 1997. No case of introduced malaria from Plasmodium falciparum has been reported in Italy since 1970.

Not Open Access | Temporal and micro-spatial heterogeneity in transmission dynamics of co-endemic Plasmodium vivax and Plasmodium falciparum in two rural cohort populations in the Peruvian Amazon

August 25, 2020 - 07:59 -- NOT Open Access
Rosas-Aguirre A, Guzman-Guzman M, Llanos-Cuentas A, et al.
J Infect Dis. 2020 Aug 21:jiaa526

Malaria is highly heterogeneous; its changing malaria micro-epidemiology needs to be addressed to support malaria elimination efforts at the regional level.

Detection of remaining Plasmodium DNA and gametocytes during follow up after curative malaria treatment among returned travellers in Norway

August 19, 2020 - 16:07 -- Open Access
Christel Gill Haanshuus and Kristine Mørch
Malaria Journal 2020 19:296, 19 August 2020

PCR can be positive weeks after effective malaria treatment, potentially leading to over diagnose of recrudescence and re-infections. The DNA detected by PCR post-treatment might stem from residuals of destroyed asexual parasites, or from live gametocytes. The objective of this clinical observational study was to describe the presence of positive PCR for Plasmodium falciparum and Plasmodium vivax in follow-up samples post-treatment from returned travellers, and the proportion of positive PCR due to gametocytes.

The characterization of extracellular vesicles-derived microRNAs in Thai malaria patients

August 11, 2020 - 13:52 -- Open Access
Nutpakal Ketprasit, Iris Simone Cheng, Fiona Deutsch, Nham Tran, Mallika Imwong, Valery Combes and Duangdao Palasuwan
Malaria Journal 2020 19:285, 10 August 2020

Extracellular vesicles (EVs) have been broadly studied in malaria for nearly a decade. These vesicles carry various functional biomolecules including RNA families such as microRNAs (miRNA). These EVs-derived microRNAs have numerous roles in host-parasite interactions and are considered promising biomarkers for disease severity. However, this field lacks clinical studies of malaria-infected samples. In this study, EV specific miRNAs were isolated from the plasma of patients from Thailand infected with Plasmodium vivax and Plasmodium falciparum. In addition, it is postulated that these miRNAs were differentially expressed in these groups of patients and had a role in disease onset through the regulation of specific target genes.

Spatial and Temporal Patterns of Malaria in Phu Yen Province, Vietnam, from 2005 to 2016

August 5, 2020 - 16:09 -- Open Access
Wangdi K, Canavati S, Duc TN, Nguyen TM, Tran LK, Kelly GC, Martin NJ, Clements ACA
J Trop Med Hyg. 2020 Aug 3

Malaria in Vietnam has become focal to a few provinces, including Phu Yen. This study aimed to assess correlations between intervention (population proportion protected by insecticide-treated nets and indoor residual spraying) and climatic variables with malaria incidence in Phu Yen Province. The Vietnam National Institute of Malariology, Parasitology, and Entomology provided incidence data for Plasmodium falciparum and Plasmodium vivax for 104 communes of Phu Yen Province from January 2005 to December 2016.


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