vivax

Vivax malaria in pregnancy and lactation: a long way to health equity

Tags:

vivax, malaria in pregnancy, health equity

Author(s):

Tobias Brummaier, Mary Ellen Gilder, Gornpan Gornsawun, Cindy S. Chu, Germana Bancone, Mupawjay Pimanpanarak, Kesinee Chotivanich, François Nosten and Rose McGready

Reference:

Malaria Journal 2020 19:40, 22 January 2020

The Sustainable Development Goals (SDG) call for increased gender equity and reduction in malaria-related mortality and morbidity. Plasmodium vivax infections in pregnancy are associated with maternal anaemia and increased adverse perinatal outcomes. Providing radical cure for women with 8-aminoquinolines (e.g., primaquine) is hindered by gender-specific complexities.

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

Tags:

immunity, sexual stage, plasmodium, falciparum, vivax, parasites

Author(s):

de Jong RM, Tebeje SK, Meerstein-Kessel L, Tadesse FG, Jore MM, Stone W, Bousema T

Reference:

Immunol Rev. 2019 Dec 16.

The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to mosquitoes. Here, we summarize evidence for naturally acquired anti‐gametocyte immunity and the current state of transmission blocking vaccines (TBV). Although gametocytes are intra‐erythrocytic when present in infected humans, developing Plasmodium falciparum gametocytes may express proteins on the surface of red blood cells that elicit immune responses in naturally exposed individuals.

Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria

Tags:

plasmodium falciparum, vivax, malaria

Author(s):

Henry Kajumbula, Wilson Byarugaba and Misaki Wayengera

Reference:

Genetic Vaccines and Therapy 2012, 10:8

We hypothesized that artificial aberration of the host-pathway by target mutagenesis of either RBC –receptors, may abolish or reduce susceptibility of the host to malaria. As a first step towards the experimental actualization of these concepts, we aimed to identify zinc finger arrays (ZFAs) for constructing ZFNs that target genes of either wild-type host-RBC- receptors.

Column: Vivax malaria, breaking the cycle of endless suffering - by George Jagoe

Tags:

malaria, vivax

"And I saw Sisyphus at his endless task raising his prodigious stone with both his hands. With hands and feet he tried to roll it up to the top of the hill, but just before he could roll it over the other side, its weight would be too much for him, and the pitiless stone would come thundering down again on to the plain. Then he would begin trying to push it up hill again, and the sweat ran off him and the steam rose after him."

The Odyssey of Homer, translated by Samuel Butler

NOT Open Access | A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Tags:

malaria, plasmodium falciparum, vivax

Author(s):

Sandra March, Shengyong Ng, Sangeeta N. Bhatia, et al.

Reference:

Cell Host & Microbe, Volume 14, Issue 1, 104-115, 17

The Plasmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage.

Medical Treatment:

antimalarial drugs

Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria

Tags:

vivax, falciparum malaria

Author(s):

Taylor WR, Widjaja H, Basri H, Tjitra E, Ohrt C, Taufik T, Baso S, Hoffman SL, Richie TL

Reference:

Malaria Journal 2013, 12:209 (19 June 2013)

Haemoglobin recovery was related to baseline Hb. Vivax-infected malaria immune Papuans had persistently lower Hb concentrations compared to non-Papuans with limited malaria exposure. This haematological disadvantage remains unexplained.

Country:

Indonesia

Event: iVAX Fellowship for Investigators from Malaria Endemic Countries

Tags:

fellowship, conference, malaria, vivax

15 travel fellowships will be awarded to scientists from malaria endemic countries that submit an abstract for the “Advances in Plasmodium vivax Malaria Research” conference, 28-30 May 2013 in Barcelona Spain.

The deadline for submission of applications is April 12, 2013.

Event: Advances in Plasmodium vivax Malaria Research & Assessing the Plasmodium vivax Research Agenda: Interdisciplinary Workshops

Tags:

event, conference, workshop, malaria, vivax

Date: 28-30 May 2013

Hour: 8am – 6pm

Venue: CosmoCaixa, Barcelona, Spain

Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi

Tags:

vivax, falciparum malaria, Plasmodium knowlesi

Author(s):

Barber BE, William T, Grigg MJ, Yeo TW, Anstey NM

Reference:

Malaria Journal 2013, 12:8 (8 January 2013)

This prospective study in Sabah, Malaysia, evaluated the accuracy of routine district and referral hospital-based microscopy, and microscopy performed by an experienced research microscopist, for the diagnosis of PCR-confirmed Plasmodium falciparum, P. knowlesi, and Plasmodium vivax malaria.

NOT Open Access | Plasmodium vivax and Plasmodium knowlesi: Cloning, expression and functional analysis of 1-Cys peroxiredoxin

Tags:

malaria, Plasmodium knowlesi, vivax

Author(s):

Hassan Hakimi, Masahito Asada, Jose Ma. M. Angeles, Satoru Kawai, Noboru Inoue, Shin-ichiro Kawazu

Reference:

Experimental Parasitology, Volume 133, Issue 1, January 2013, Pages 101–105

Malaria parasites like other aerobes need to detoxify the reactive oxygen species (ROS) that are mainly produced from hemoglobin degradation in the food vacuole.

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