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vivax

Spatial and Temporal Patterns of Malaria in Phu Yen Province, Vietnam, from 2005 to 2016

August 5, 2020 - 16:09 -- Open Access
Author(s): 
Wangdi K, Canavati S, Duc TN, Nguyen TM, Tran LK, Kelly GC, Martin NJ, Clements ACA
Reference: 
J Trop Med Hyg. 2020 Aug 3

Malaria in Vietnam has become focal to a few provinces, including Phu Yen. This study aimed to assess correlations between intervention (population proportion protected by insecticide-treated nets and indoor residual spraying) and climatic variables with malaria incidence in Phu Yen Province. The Vietnam National Institute of Malariology, Parasitology, and Entomology provided incidence data for Plasmodium falciparum and Plasmodium vivax for 104 communes of Phu Yen Province from January 2005 to December 2016.

Association between the proportion of Plasmodium falciparum and Plasmodium vivax infections detected by passive surveillance and the magnitude of the asymptomatic reservoir in the community: a pooled analysis of paired health facility and community data

August 3, 2020 - 15:54 -- Open Access
Author(s): 
Stresman G, Sepúlveda N, Fornace K, et al.
Reference: 
Lancet Infect Dis. 2020 Aug;20(8):953-963

Passively collected malaria case data are the foundation for public health decision making. However, because of population-level immunity, infections might not always be sufficiently symptomatic to prompt individuals to seek care. Understanding the proportion of all Plasmodium spp infections expected to be detected by the health system becomes particularly paramount in elimination settings. The aim of this study was to determine the association between the proportion of infections detected and transmission intensity for Plasmodium falciparum and Plasmodium vivax in several global endemic settings.

Hotspots in Plasmodium and RBC Receptor-Ligand Interactions: Key Pieces for Inhibiting Malarial Parasite Invasion

July 7, 2020 - 13:48 -- Open Access
Author(s): 
Patarroyo MA, Molina-Franky J, Gómez M, Arévalo-Pinzón G, Patarroyo ME
Reference: 
Int J Mol Sci. 2020 Jul 2;21(13):E4729

Protein-protein interactions (IPP) play an essential role in practically all biological processes, including those related to microorganism invasion of their host cells. It has been found that a broad repertoire of receptor-ligand interactions takes place in the binding interphase with host cells in malaria, these being vital interactions for successful parasite invasion. Several trials have been conducted for elucidating the molecular interface of interactions between some Plasmodium falciparum and Plasmodium vivax antigens with receptors on erythrocytes and/or reticulocytes.

Re-introduction of vivax malaria in a temperate area (Moscow region, Russia): a geographic investigation

March 23, 2020 - 11:37 -- Open Access
Author(s): 
Varvara A. Mironova, Natalia V. Shartova, Andrei E. Beljaev, Mikhail I. Varentsov, Fedor I. Korennoy and Mikhail Y. Grishchenko
Reference: 
Malaria Journal 2020 19:116, 18 March 2020

Between 1999 and 2008 Russia experienced a flare-up of transmission of vivax malaria following its massive importation with more than 500 autochthonous cases in European Russia, the Moscow region being the most affected. The outbreak waned soon after a decrease in importation in mid-2000s and strengthening the control measures. Compared with other post-eradication epidemics in Europe this one was unprecedented by its extension and duration.

NOT Open Access | Capture and Detection of Plasmodium vivax Lactate Dehydrogenase in a Bead-Based Multiplex Immunoassay

March 9, 2020 - 14:30 -- NOT Open Access
Author(s): 
Rogier E, Nace D, Ljolje D, Lucchi NW, Udhayakumar V, Aidoo M
Reference: 
Am J Trop Med Hyg. 2020 Mar 2

Laboratory detection of malaria antigens has proved valuable for research and epidemiological purposes. We recently developed a bead-based multiplex antigen assay for pan-Plasmodium and Plasmodium falciparum targets. Here, we report integration of a Plasmodium vivax–specific target to this multiplex panel: P. vivax lactate dehydrogenase (PvLDH).

NOT Open Access | Early endothelial activation precedes glycocalyx degradation and microvascular dysfunction in experimentally induced Plasmodium falciparum and Plasmodium vivax infection

March 9, 2020 - 14:24 -- NOT Open Access
Author(s): 
Woodford J, Yeo TW, Piera KA, Butler K, Weinberg JB, McCarthy JS, Anstey NM, Barber BE
Reference: 
Infect Immun. 2020 Mar 2. pii: IAI.00895-19

Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced P. falciparum and P. vivax infection.

Vivax malaria in pregnancy and lactation: a long way to health equity

January 27, 2020 - 13:30 -- Open Access
Author(s): 
Tobias Brummaier, Mary Ellen Gilder, Gornpan Gornsawun, Cindy S. Chu, Germana Bancone, Mupawjay Pimanpanarak, Kesinee Chotivanich, François Nosten and Rose McGready
Reference: 
Malaria Journal 2020 19:40, 22 January 2020

The Sustainable Development Goals (SDG) call for increased gender equity and reduction in malaria-related mortality and morbidity. Plasmodium vivax infections in pregnancy are associated with maternal anaemia and increased adverse perinatal outcomes. Providing radical cure for women with 8-aminoquinolines (e.g., primaquine) is hindered by gender-specific complexities.

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

December 23, 2019 - 14:55 -- Open Access
Author(s): 
de Jong RM, Tebeje SK, Meerstein-Kessel L, Tadesse FG, Jore MM, Stone W, Bousema T
Reference: 
Immunol Rev. 2019 Dec 16.

The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to mosquitoes. Here, we summarize evidence for naturally acquired anti‐gametocyte immunity and the current state of transmission blocking vaccines (TBV). Although gametocytes are intra‐erythrocytic when present in infected humans, developing Plasmodium falciparum gametocytes may express proteins on the surface of red blood cells that elicit immune responses in naturally exposed individuals.

Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria

October 27, 2014 - 16:38 -- Open Access
Author(s): 
Henry Kajumbula, Wilson Byarugaba and Misaki Wayengera
Reference: 
Genetic Vaccines and Therapy 2012, 10:8

We hypothesized that artificial aberration of the host-pathway by target mutagenesis of either RBC –receptors, may abolish or reduce susceptibility of the host to malaria. As a first step towards the experimental actualization of these concepts, we aimed to identify zinc finger arrays (ZFAs) for constructing ZFNs that target genes of either wild-type host-RBC- receptors.

Column: Vivax malaria, breaking the cycle of endless suffering - by George Jagoe

July 10, 2014 - 10:56 -- Ingeborg van Schayk
Tags: 
"And I saw Sisyphus at his endless task raising his prodigious stone with both his hands. With hands and feet he tried to roll it up to the top of the hill, but just before he could roll it over the other side, its weight would be too much for him, and the pitiless stone would come thundering down again on to the plain. Then he would begin trying to push it up hill again, and the sweat ran off him and the steam rose after him."
The Odyssey of Homer, translated by Samuel Butler
 

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