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t cells

T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice

November 17, 2021 - 09:26 -- Open Access
Brandi J, Lehmann C, Kaminski LC, Schulze Zur Wiesch J, Addo M, Ramharter M, Mackroth M, Jacobs T, Riehn M
Eur J Immunol. 2021 Nov 9

Overwhelming activation of T cells in acute malaria is associated with severe outcomes. Thus, counter-regulation by anti-inflammatory mechanisms is indispensable for an optimal resolution of disease. Using Plasmodium berghei ANKA (PbA) infection of C57BL/6 mice, we performed a comprehensive analysis of co-inhibitory molecules expressed on CD4+ and CD8+ T cells using an unbiased cluster analysis approach. We identified similar T cell clusters co-expressing several co-inhibitory molecules like programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 (LAG-3) in the CD4+ and the CD8+ T cell compartment.

NOT Open Access | Human unconventional T cells in Plasmodium falciparum infection

February 25, 2020 - 16:13 -- NOT Open Access
Schmaler M, Orlova-Fink N, Rutishauser T, Abdulla S, Daubenberger C
Semin Immunopathol. 2020 Feb 19

Malaria is an old scourge of humankind and has a large negative impact on the economic development of affected communities. Recent success in malaria control and reduction of mortality seems to have stalled emphasizing that our current intervention tools need to be complemented by malaria vaccines.

Not Open Access | Presence of Memory T Cells and Naturally Acquired Antibodies in Plasmodium vivax Malaria-Exposed Individuals Against a Group of Tryptophan-Rich Antigens With Conserved Sequences

December 18, 2012 - 17:45 -- NOT Open Access
Mohammad Zeeshan, Hema Bora and Yagya Dutta Sharma
J Infect Dis. (2013) 207 (1): 175-185

These results suggest the presence of memory T cells in humans against these antigens to generate faster and more specific immune responses to minimize the P. vivax infection.

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