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Surveillance based estimation of burden of malaria in India, 2015–2016

April 20, 2020 - 08:48 -- Open Access
Ashwani Kumar, Himanshu K. Chaturvedi, Ajeet Kumar Mohanty, Surya Kant Sharma, Mantoshkumar S. Malhotra and Arvind Pandey
Malaria Journal 2020 19:156, 16 April 2020

India has launched the malaria elimination initiative in February 2016. Studies suggest that estimates of malaria are useful to rationalize interventions and track their impact. Hence, a national study was launched to estimate burden of malaria in India in 2015.

Comparative analysis of Plasmodium falciparum dihydrofolate-reductase gene sequences from different regions of India

April 14, 2020 - 14:37 -- Open Access
Kumar A, Gahlawat SK, Singh V
Heliyon. 2020 Apr 6;6(4):e03715

Molecular surveillance of the drug resistance genes in parasite can be used for monitoring/surveillance of drug resistance in endemic malaria areas. Here we report the prevalence of single nucleotide polymorphisms (SNPs) in dihydrofolate reductase (dhfr) gene in nucleotide sequence of Plasmodium falciparum from different regions in India.

NOT Open Access | Intensity of pyrethroid resistance in Anopheles culicifacies s.l. (Diptera: Culicidae) in Odisha State, India

April 13, 2020 - 15:14 -- NOT Open Access
Sahu SS, Thankachy S, Dash S, Kasinathan G, Kumar A
Pathog Glob Health. 2020 Apr 10:1-7.

Anopheles culicifacies s.l. is the principal malaria vector in India and has recently developed resistance to synthetic pyrethroids. For identifying the possible operational impact, quantitative measure of the intensity of this resistance is required. The purpose of this study was to measure the intensity of pyrethroid resistance in An. culicifacies s.l.

NOT Open Access | Malaria epidemics in India: Role of climatic condition and control measures

April 13, 2020 - 14:15 -- NOT Open Access
Baghbanzadeh M, Kumar D, Yavasoglu SI, Manning S, Hanafi-Bojd AA, Ghasemzadeh H, Sikder I, Kumar D, Murmu N, Haque U
Science of The Total Environment Volume 712, 10 April 2020, 136368

Malaria is a major public health problem in India, which is the second most populous country in the world. This study aimed to investigate the impact of climatic parameters and malaria control efforts implemented by the Indian national malaria control program on malaria epidemics between January of 2009 and December of 2015.

NOT Open Access | Peripheral Merozoite Surface Proteins Are Targets of Naturally Acquired Immunity against Malaria in both India and Ghana

March 30, 2020 - 10:37 -- NOT Open Access
Garcia-Senosiain A, Kana IH, Singh SK, Chourasia BK, Das MK, Dodoo D, Singh S, Adu B, Theisen M
Infect Immun. 2020 Mar 23;88(4). pii: e00778-19

Development of a successful blood-stage vaccine against Plasmodium falciparum malaria remains a high priority. Immune-epidemiological studies are effective tools for the identification of antigenic targets of naturally acquired immunity (NAI) against malaria. However, differences in study design and methodology may compromise interstudy comparisons.

Evaluation of Implementation of Intermittent Screening and Treatment for Control of Malaria in Pregnancy in Jharkhand, India

March 17, 2020 - 16:25 -- Open Access
Webster J, Mishra V, Anvikar A, Kuepfer I, Hoyt J, Bruce J, Greenwood B, Chandramohan D, Valecha N, Mishra N
Am J Trop Med Hyg. 2020 Mar 9

This study evaluated intermittent screening and treatment during pregnancy (ISTp) for malaria using rapid diagnostic tests (RDTs) at antenatal care (ANC) compared with passive case detection within the routine health system. The mixed-method evaluation included two cross-sectional household surveys (pre- and post-implementation of ISTp), in-depth interviews with health workers, and focus group discussions (FGDs) with pregnant women.

NOT Open Access | MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India

March 9, 2020 - 14:35 -- NOT Open Access
van Loon W, Gai PP, Kulkarni SS, Rasalkar R, Siegert K, Wedam J, Boloor A, Baliga S, Kumar A, Jain A, Mahabala C, Shenoy D, Devi R, Gai P, Mockenhaupt FP
Am J Trop Med Hyg. 2020 Mar 2

Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. Here, we examined whether this association holds true in a different population, that is, 449 mainly male and adult malaria patients and 666 community controls in southwestern India. Plasmodium vivax malaria (67%) predominated over falciparum malaria (11%) and mixed species infections (22%).

Prevalence of Plasmodium falciparum field isolates with deletions in histidine-rich protein 2 and 3 genes in context with sub-Saharan Africa and India: a systematic review and meta-analysis

February 3, 2020 - 16:36 -- Open Access
Loick P. Kojom and Vineeta Singh
Malaria Journal 2020 19:46, 28 January 2020

In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. However, the chances of RDT-oriented successful treatment are increasingly jeopardized by the appearance of mutants with deletions in pfhrp2 and pfhrp3 genes. This systematic review and meta-analysis determines the prevalence of field P. falciparum isolates with deletion in pfhrp2 and/or pfhrp3 genes and their proportion among false-negative results in the PfHRP2-based RDTs in SSA and India.

Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India

January 27, 2020 - 13:40 -- Open Access
Kasinathan Gunasekaran, Sudhansu Sekhar Sahu, Tharmalingam Vijayakumar, Swaminathan Subramanian, Manju Rahi and Purushothaman Jambulingam
Malaria Journal 2020 19:43, 23 January 2020

The development of resistance in vectors is one of the major impediments for malaria control. Adding synergists to insecticides has proven to be an alternative choice for controlling resistant mosquitoes. DawaPlus 3.0 and DawaPlus 4.0 are new long-lasting insecticidal nets (LLINs) in which deltamethrin and a synergist, piperonyl butoxide (PBO) are added into filaments and their efficacy was tested against resistant malaria vector, Anopheles culicifacies in experimental huts in India.

Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India

January 27, 2020 - 13:29 -- Open Access
Deepali Savargaonkar, Manoj Kumar Das, Amar Verma, Jeevan K. Mitra, C. P. Yadav, Bina Srivastava, Anupkumar R. Anvikar and Neena Valecha
Malaria Journal 2020 19:39, 22 January 2020

Parenteral artesunate is the treatment of choice for severe malaria. It is safe, efficacious and well tolerated anti-malarial. However, delayed haemolysis has been reported in travellers, non-immune individuals and in African children.


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