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Rolling out the radical cure for vivax malaria in Asia: a qualitative study among policy makers and stakeholders

March 24, 2021 - 14:50 -- Open Access
Bipin Adhikari, Ghulam Rhahim Awab and Lorenz von Seidlein
Malaria Journal 2021 20:164, 23 March 2021

Wide-spread implementation of treatment regimens for the radical cure of vivax malaria is hindered by a range of factors. This has resulted in an increase in the relative proportion of vivax malaria and is an important obstacle in the achievement of global malaria elimination by 2030. The main objective of this study was to explore the current policies guiding the treatment plans on vivax malaria, and the factors affecting the implementation of radical cure in South/South East Asian and Asian Pacific countries.

NOT Open Access | Artemisia annua - Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications

January 26, 2021 - 15:19 -- NOT Open Access
Ekiert H, Świątkowska J, Klin P, Rzepiela A, Szopa A
Planta Med. 2021 Jan 22

Artemisia annua (annual mugwort) is a species that has long been used in traditional Asian medicine, mainly Chinese and Hindu. The species is widespread and known as a medicinal plant not only in Asia but also in Europe, in both Americas, and Australia. The species has become a subject of particular interest due to the 2015 Nobel Prize awarded for detecting the sesquiterpene lactone artemisinin in it and proving its antimalarial activities. The raw materials obtained from this species are Artemisiae annuae folium and Artemisiae annuae herba.

Bayesian spatio-temporal modeling of malaria risk in Rwanda

September 15, 2020 - 10:41 -- Open Access
Semakula M, Niragire FI, Faes C
PLoS One. 2020 Sep 10;15(9):e0238504

Every year, 435,000 people worldwide die from Malaria, mainly in Africa and Asia. However, malaria is a curable and preventable disease. Most countries are developing malaria elimination plans to meet sustainable development goal three, target 3.3, which includes ending the epidemic of malaria by 2030. Rwanda, through the malaria strategic plan 2012-2018 set a target to reduce malaria incidence by 42% from 2012 to 2018.

NOT Open Access | Decreased Mortality of falciparum Malaria in Anemic Prisoners of War

September 10, 2020 - 08:46 -- NOT Open Access
Shanks GD
Am J Trop Med Hyg. 2020 Sep 8

Modern clinical trials have suggested that anemia protects against malaria mortality. Military records of the Second World War in Asia were examined to see if there was support for this hypothesis. When relatively well-nourished Imperial Japanese Navy sailors captured on Nauru (n = 799) were imprisoned on the Fauro Islands, 26% died from falciparum malaria.

Molecular epidemiological surveillance of Africa and Asia imported malaria in Wuhan, Central China: comparison of diagnostic tools during 2011–2018

September 5, 2020 - 14:58 -- Open Access
Yiting Xie, Kai Wu, Weijia Cheng, Tingting Jiang, Yi Yao, Mingxing Xu, Yan Yang, Huabing Tan and Jian Li
Malaria Journal 2020 19:321, 3 September 2020

Malaria remains a serious public health problem globally. As the elimination of indigenous malaria continues in China, imported malaria has gradually become a major health hazard. Well-timed and accurate diagnoses could support the timely implementation of therapeutic schedules, reveal the prevalence of imported malaria and avoid transmission of the disease.

Age influences the thermal suitability of Plasmodium falciparum transmission in the Asian malaria vector Anopheles stephensi

July 22, 2020 - 15:44 -- Open Access
Miazgowicz KL, Shocket MS, Ryan SJ, Villena OC, Hall RJ, Owen J, Adanlawo T, Balaji K, Johnson LR, Mordecai EA, Murdock CC
Proc Biol Sci. 2020 Jul 29;287(1931):20201093

Models predicting disease transmission are vital tools for long-term planning of malaria reduction efforts, particularly for mitigating impacts of climate change. We compared temperature-dependent malaria transmission models when mosquito life-history traits were estimated from a truncated portion of the lifespan (a common practice) versus traits measured across the full lifespan.

The Role of Mass Drug Administration of Antimalarials

July 7, 2020 - 12:51 -- Open Access
Alonso PL
Am. J. Trop. Med. Hyg., 00(00), 2020, pp. 1–2

Either intuition or empiricism must have led to the use of antimalarial drugs to both treat and prevent malaria, pre-dating the identification of the malaria parasite and the mode of its transmission. Josep Masdevall in the XVIII century managed epidemics in Spain through the administration of compounds that included the bark of the cinchona tree. In more recent times, mass drug administration (MDA) was the first form of chemoprevention used against malaria in the early 1900s.

High-efficiency enrichment enables identification of aptamers to circulating Plasmodium falciparum-infected erythrocytes

June 17, 2020 - 13:06 -- Open Access
Oteng EK, Gu W, McKeague M
Sci Rep. 2020 Jun 16; 10(1):9706

Plasmodium falciparum is the causative agent of the deadliest human malaria. New molecules are needed that can specifically bind to erythrocytes that are infected with P. falciparum for diagnostic purposes, to disrupt host-parasite interactions, or to deliver chemotherapeutics. Aptamer technology has the potential to revolutionize biological diagnostics and therapeutics; however, broad adoption is hindered by the high failure rate of the systematic evolution of ligands by exponential enrichment (SELEX). Here we performed parallel SELEX experiments to compare the impact of two different methods for single-strand recovery on the efficiency of aptamer enrichment.

Identification of a conserved var gene in different Plasmodium falciparum strains

June 2, 2020 - 09:29 -- Open Access
Sandra Dimonte, Ellen I. Bruske, Corinna Enderes, Thomas D. Otto, Louise Turner, Peter Kremsner and Matthias Frank
Malaria Journal 2020 19:194, 29 May 2020

The multicopy var gene family of Plasmodium falciparum is of crucial importance for pathogenesis and antigenic variation. So far only var2csa, the var gene responsible for placental malaria, was found to be highly conserved among all P. falciparum strains. Here, a new conserved 3D7 var gene (PF3D7_0617400) is identified in several field isolates.

NOT Open Access | The end of the artemisinin era - - we should aim at malaria eradication in Asia using free effective treatment

May 29, 2020 - 14:32 -- NOT Open Access
Petersen E, Picot S
Clin Infect Dis. 2020 May 27:ciaa625

No abstract available


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