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NOT Open Access | Efficacy and Safety of a Naphthoquine-Azithromycin Co-Formulation for Malaria Prophylaxis in Southeast Asia: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial

July 21, 2020 - 15:13 -- NOT Open Access
Yang H, Wang J, Cui L, et al.
Clin Infect Dis. 2020 Jul 20:ciaa1018

A prophylactic antimalarial drug that is both effective for protection and improves compliance is in high demand.

Malaria prophylaxis approach during COVID-19 pandemic

May 6, 2020 - 14:58 -- Open Access
Rodriguez-Valero N, Vera I, Torralvo MR, De Alba T, Ferrer E, Camprubi D, Almuedo Riera A, Gallego RS, Muelas M, Pinazo MJ, Muñoz J
Travel Med Infect Dis. 2020 Apr 29:101716

Malaria drugs chloroquine and hydroxychloroquine are currently being evaluated in a number of clinical trials as active treatments against SARS-CoV-2 virus. They are also postulated for pre and postexposure prophylaxis for the prevention of COVID-19. It has been recently shown that both molecules inhibit in-vitro the entry of the virus in the cell, and they can stop the cytokine storm derived from the infection alongside impeding T cell activation [1,2]. In particular, hydroxychloroquine is a drug with an excellent safety profile, even for pregnant women. Furthermore, hydroxychloroquine has been successfully used during decades for the management of rheumatologic diseases modulating inflammation and organ damage [3].

NOT Open Access | Ivermectin for causal malaria prophylaxis: a randomised controlled human infection trial

March 9, 2020 - 13:32 -- Kabogo Ndegwa
Metzger WG, Theurer A, Pfleiderer A, Molnar Z, Maihöfer-Braatting D, Bissinger AL, Sulyok Z, Köhler C, Egger-Adam D, Lalremruata A, Esen M, Lee Sim K, Hoffman S, Rabinovich R, Chaccour C, Alonso P, Mordmüller BG, Kremsner PG
Tropical Medicine and International Health Volume 25, Issue 3, March 2020, Pages 380-386

Ivermectin is safe and widely used for treating helminth infections. It also kills arthropods feeding on treated subjects, including malaria vectors. Thus, ivermectin mass drug administration as an additional tool for malaria control is being evaluated by WHO. As in vitro data, animal experiments and epidemiological observations suggest that ivermectin has a direct effect on the liver stages of the malaria parasite, this study was designed to assess the prophylactic effect of ivermectin on Plasmodium falciparum controlled human malaria infection.

NOT Open Access | Mefloquine for malaria prophylaxis in military personnel

March 2, 2020 - 14:05 -- NOT Open Access
Williamson V, Blamey H, Sharpley J, David A, Greenberg N
BMJ Mil Health. 2020 Feb 20. pii: jramc-2019-001295

The British Army adopted mefloquine (Lariam) as its preferred drug for chemoprophylaxis against malaria in 1993. Treatment doses of mefloquine had already been reported to cause an acute brain syndrome. In 1996, army doctors reported a private soldier who, after six doses of mefloquine prophylaxis, saw the Grim Reaper standing behind the chaplain, heard incoherent voices, and was admitted to a psychiatric hospital; more reports followed.

Non-adherence to malaria prophylaxis: The influence of travel-related and psychosocial factors

November 12, 2019 - 15:59 -- Open Access
Jolanda G.M. Hoefnagel, Karlijn Massar, Jeannine L.A. Hautvast
Journal of Infection and Public Health, 6 November 2019

The effectiveness of malaria chemoprophylaxis is limited by a lack of compliance in travellers. This study assesses the demographic, travel-related, and psychosocial determinants of non-compliance with chemoprophylaxis.

Should Artemisia annua (wormwood) tea be used as a prophylactic in endemic countries?

December 18, 2012 - 14:56 -- Bart G.J. Knols

This expert blog was contributed by Dr. Merlin Willcox, Honorary Secretary of the Research Initiative on Traditional Antimalarial Methods (RITAM), in response to the outcome of a poll on MalariaWorld and recent contributions regarding the use of Artemisia tea as a remedy for malaria.

As a scientist and medical doctor, I am interested in herbal medicines for malaria. No one can deny that they have been the source of the two most important and effective families of antimalarial drugs. Furthermore many people still rely on various herbal remedies for treating uncomplicated malaria. Much of my own research has aimed to investigate these objectively and to find the most effective remedies.
Artemisia annua is a very interesting plant and is the source of the most powerful antimalarial drug ever discovered, artemisinin. There are a few clinical trials which even show that it can be used as an “emergency, first-aid” treatment for malaria in semi-immune adults. However there are no published clinical trials which prove effect on the prevention of malaria, and no published clinical trials which demonstrate effectiveness in young children...

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