A vaccine would greatly accelerate current global efforts towards malaria elimination. While a partially efficacious vaccine has been achieved for Plasmodium falciparum, a major bottleneck in developing highly efficacious vaccines is a lack of reliable correlates of protection, and the limited application of assays that quantify functional immune responses to evaluate and down-select vaccine candidates in pre-clinical studies and clinical trials.
Malaria is an infection disease caused by plamodium parasite. Sporadic cases have not been observed since 2011, but imported cases still present owing to travel. In this study, we aimed to evaluate labotauary and clinical findings patients with malaria who were hospitalized and treated in our hospital.
Rapid diagnostic tests (RDT) for malaria are common, but their performance varies. Tests using histidine-rich protein 2 (HRP2) antigen are most common, and many have high sensitivity. HRP2 tests can remain positive for weeks after treatment, limiting their specificity and usefulness in high-transmission settings. Tests using Plasmodium lactate dehydrogenase (pLDH) have been less widely used but have higher specificity, mostly due to a much shorter time to become negative.
A clear understanding of mosquito biology is fundamental to the control efforts of mosquito-borne diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular method of measuring the survival and dispersal of disease vectors; however, examples with African malaria vectors are limited. Ethical and technical difficulties involved in carrying out MMRR studies may have held back research in this area and, therefore, a device that marks mosquitoes as they emerge from breeding sites was developed and evaluated to overcome the problems of MMRR.
MEASURE Evaluation, a USAID-funded project, is excited to announce the launch of the M&E of Malaria Programs e-course.
M&E of Malaria Programs provides an overview of fundamental concepts of monitoring and evaluation as they specifically relate to malaria prevention and control programs. It provides an overview of: