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HIV

COVID-19 and Syndemic challenges in 'Battling the Big Three': HIV, TB and malaria

March 31, 2021 - 14:20 -- Open Access
Author(s): 
Velavan TP, Meyer CG, Esen M, Kremsner PG, Ntoumi F
Reference: 
Int J Infect Dis. 2021 Mar 26:S1201-9712(21)00289-7

Indirect effects of the COVID-19 pandemic have the potential to seriously undermine the health system in sub-Saharan Africa with an increase in the incidences of malaria, tuberculosis (TB) and HIV infections.

NOT Open Access | Evaluation of the effects of atazanavir-ritonavir on the pharmacokinetics of lumefantrine in patients living with HIV in Lagos University Teaching Hospital, South-Western Nigeria

March 24, 2021 - 15:10 -- NOT Open Access
Author(s): 
Usman SO, Oreagba IA, Akanmu AS, et al.
Reference: 
Eur J Clin Pharmacol. 2021 Mar 23

Atazanavir-ritonavir (ATVr)-based antiretroviral therapy and artemether-lumefantrine (AL) are commonly used drugs for the treatment of human immune deficiency virus (HIV) infection and malaria respectively. However, interaction of both drugs, with Cytochrome P 3A4 (CYP 3A4) isoenzyme, may spawn clinically significant pharmacokinetic interactions. This study evaluated the effects of atazanavir-ritonavir on the pharmacokinetics of lumefantrine.

Malaria and intestinal parasite co-infection and its association with anaemia among people living with HIV in Buea, Southwest Cameroon: A community-based retrospective cohort study

January 27, 2021 - 10:45 -- Open Access
Author(s): 
Mekachie Sandie S, Sumbele IUN, Tasah MM, Kimbi HK
Reference: 
PLoS One. 2021 Jan 22;16(1):e0245743

Both malaria and intestinal parasites are endemic in Cameroon, and their co-infection can be of great impact on anaemia among people living with HIV (PLWH). This community-based retrospective cohort study determined the prevalence and association of infections with anaemia in PLWH and HIV-negative individuals in Buea, Cameroon from March to August 2019.

Increased malaria parasitaemia among adults living with HIV who have discontinued cotrimoxazole prophylaxis in Kitgum district, Uganda

November 12, 2020 - 15:47 -- Open Access
Author(s): 
Orishaba P, Kalyango JN, Nankabirwa JI, et al.
Reference: 
PLoS One. 2020 Nov 11;15(11):e0240838

Although WHO recommends cotrimoxazole (CTX) discontinuation among HIV patients who have undergone immune recovery and are living in areas of low prevalence of malaria, some countries including Uganda recommend CTX discontinuation despite having a high malaria burden. We estimated the prevalence and factors associated with malaria parasitaemia among adults living with HIV attending hospital outpatient clinic before and after discontinuation of CTX prophylaxis.

NOT Open Access | Asymptomatic Malaria Co-infection of HIV-infected Adults in Nigeria. Prevalence of and Impact on Cognition, Mood and Biomarkers of Systemic Inflammation

October 7, 2020 - 15:43 -- NOT Open Access
Author(s): 
Bharti AR, McCutchan JA, Umlauf A, Okwuegbuna OK, Letendre S, Cherner M, Burdo T, Jumare J, Williams K, Blattner W, Royal W
Reference: 
J Acquir Immune Defic Syndr. 2020 Oct 1

HIV and malaria are associated with immunological perturbations and neurocognitive disorders even when asymptomatic. However, the effect of asymptomatic malaria (AM) in HIV-infected adults on neurocognitive impairment (NCI) is not well understood. This study investigated the biomarkers of systemic inflammation and neurocognition in dually-infected Nigerian adults.

NOT Open Access | Piperaquine exposure is altered by pregnancy, HIV and nutritional status in Ugandan women

October 7, 2020 - 15:38 -- NOT Open Access
Author(s): 
Hughes E, Imperial M, Savic RM, et al.
Reference: 
Antimicrob Agents Chemother. 2020 Oct 5:AAC.01013-20

Dihydroartemisinin-piperaquine (DHA-PQ) provides highly effective therapy and chemoprevention for malaria in pregnant African women. PQ concentrations >10.3 ng/mL have been associated with reduced maternal parasitemia, placental malaria and improved birth outcomes. We characterized the population pharmacokinetics (PK) of PQ in a post-hoc analysis of human immunodeficiency virus (HIV)-infected and -uninfected pregnant women receiving DHA-PQ as chemoprevention every 4 or 8 weeks.

HIV, tuberculosis, and malaria: how can the impact of COVID-19 be minimised

July 20, 2020 - 15:17 -- Open Access
Author(s): 
Sands P
Reference: 
Lancet Glob Health. 2020 Jul 13:S2214-109X (20)30317-X

In The   Lancet   Global   Health,   Alexandra   Hogan   and   colleagues1  report  the  findings  of  a  modelling  study  in  which  they  estimate  the  number  of  excess  deaths  from  HIV,  tuberculosis,  and  malaria  that  could  plausibly  occur   as   a   consequence   of   the   COVID-19   pandemic.  

DFIQ, a Novel Quinoline Derivative, Shows Anticancer Potential by Inducing Apoptosis and Autophagy in NSCLC Cell and In Vivo Zebrafish Xenograft Models

June 1, 2020 - 16:20 -- Open Access
Author(s): 
Huang HW, Bow YD, Wang CY, Chen YC, Fu PR, Chang KF, Wang TW, Tseng CH, Chen YL, Chiu CC
Reference: 
Cancers (Basel). 2020 May 25; 12(5):E1348

Lung cancer is one of the deadliest cancers worldwide due to chemoresistance in patients with late-stage disease. Quinoline derivatives show biological activity against HIV, malaria, bacteriuria, and cancer. DFIQ is a novel synthetic quinoline derivative that induces cell death in both in vitro and in vivo zebrafish xenograft models. DFIQ induced cell death, including apoptosis, and the IC50 values were 4.16 and 2.31 μM at 24 and 48 h, respectively.

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

September 10, 2019 - 15:15 -- Open Access
Author(s): 
Eliud O. Odhiambo, Dibyadyuti Datta, Bernard Guyah, George Ayodo, Bartholomew N. Ondigo, Benard O. Abong’o, Chandy C. John and Anne E. P. Frosch
Reference: 
Malaria Journal 2019 18:297, 30 August 2019

HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody responses.

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Role of secondary level laboratories in strengthening quality at primary level health facilities’ laboratories: an innovative approach to ensure accurate HIV, tuberculosis, and malaria test results in resource-limited settings

December 11, 2012 - 07:12 -- Open Access
Author(s): 
Tsegahun Manyazewal, Antonio D. Paterniti, Robert R. Redfield, Francesco Marinucci
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 75, Issue 1, January 2013, Pages 55–59
MalariaWorld

Providing regular external quality assessment of primary level laboratories and timely feedback is crucial to ensure the reliability of testing capacity of the whole laboratory network.

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