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HIV

HIV, tuberculosis, and malaria: how can the impact of COVID-19 be minimised

July 20, 2020 - 15:17 -- Open Access
Author(s): 
Sands P
Reference: 
Lancet Glob Health. 2020 Jul 13:S2214-109X (20)30317-X

In The   Lancet   Global   Health,   Alexandra   Hogan   and   colleagues1  report  the  findings  of  a  modelling  study  in  which  they  estimate  the  number  of  excess  deaths  from  HIV,  tuberculosis,  and  malaria  that  could  plausibly  occur   as   a   consequence   of   the   COVID-19   pandemic.  

DFIQ, a Novel Quinoline Derivative, Shows Anticancer Potential by Inducing Apoptosis and Autophagy in NSCLC Cell and In Vivo Zebrafish Xenograft Models

June 1, 2020 - 16:20 -- Open Access
Author(s): 
Huang HW, Bow YD, Wang CY, Chen YC, Fu PR, Chang KF, Wang TW, Tseng CH, Chen YL, Chiu CC
Reference: 
Cancers (Basel). 2020 May 25; 12(5):E1348

Lung cancer is one of the deadliest cancers worldwide due to chemoresistance in patients with late-stage disease. Quinoline derivatives show biological activity against HIV, malaria, bacteriuria, and cancer. DFIQ is a novel synthetic quinoline derivative that induces cell death in both in vitro and in vivo zebrafish xenograft models. DFIQ induced cell death, including apoptosis, and the IC50 values were 4.16 and 2.31 μM at 24 and 48 h, respectively.

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

September 10, 2019 - 15:15 -- Open Access
Author(s): 
Eliud O. Odhiambo, Dibyadyuti Datta, Bernard Guyah, George Ayodo, Bartholomew N. Ondigo, Benard O. Abong’o, Chandy C. John and Anne E. P. Frosch
Reference: 
Malaria Journal 2019 18:297, 30 August 2019

HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lymphopenia and immune activation affect malaria-specific antibody responses.

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Role of secondary level laboratories in strengthening quality at primary level health facilities’ laboratories: an innovative approach to ensure accurate HIV, tuberculosis, and malaria test results in resource-limited settings

December 11, 2012 - 07:12 -- Open Access
Author(s): 
Tsegahun Manyazewal, Antonio D. Paterniti, Robert R. Redfield, Francesco Marinucci
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 75, Issue 1, January 2013, Pages 55–59
MalariaWorld

Providing regular external quality assessment of primary level laboratories and timely feedback is crucial to ensure the reliability of testing capacity of the whole laboratory network.

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