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plasmodium chabaudi

NOT Open Access | Coinfection with Blood-Stage Plasmodium Promotes Systemic Type I Interferon Production during Pneumovirus Infection but Impairs Inflammation and Viral Control in the Lung

April 30, 2015 - 12:50 -- NOT Open Access
Author(s): 
Chelsea L. Edwards, Vivian Zhang, Ashraful Haque, et al.
Reference: 
Clin Vaccine Immunol May 2015 vol. 22 no. 5 477-483

Acute lower respiratory tract infections (ALRTI) are the leading cause of global childhood mortality, with human respiratory syncytial virus (hRSV) being a major cause of viral ALRTI in young children worldwide.

Person: 

Disruption of IL-21 Signaling Affects T Cell-B Cell Interactions and Abrogates Protective Humoral Immunity to Malaria

March 16, 2015 - 08:45 -- Open Access
Author(s): 
Damián Pérez-Mazliah, Dorothy Hui Lin Ng, Ana Paula Freitas do Rosário, Sarah McLaughlin, Béatris Mastelic-Gavillet, Jan Sodenkamp, Garikai Kushinga, Jean Langhorne
Reference: 
PLoS Pathog 11(3): e1004715

Interleukin-21 signaling is important for germinal center B-cell responses, isotype switching and generation of memory B cells.

Correction: disrupting rhythms in Plasmodium chabaudi: costs accrue quickly and independently of how infections are initiated

December 22, 2014 - 13:56 -- Open Access
Author(s): 
O'Donnell AJ, Mideo N, Reece SE
Reference: 
Malaria Journal 2014, 13 :503 (17 December 2014)

Some of the data in the article [1] were inadvertently mislabelled.

CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria

May 28, 2014 - 07:29 -- Open Access
Author(s): 
Lei Shong Lau, Daniel Fernandez-Ruiz, William R. Heath, et al.
Reference: 
PLoS Pathog 10(5): e1004135

To follow the fate of CD8+ T cells responsive to Plasmodium berghei ANKA (PbA) infection, we generated an MHC I-restricted TCR transgenic mouse line against this pathogen.

NOT Open Access | IFN-γ–Induced Priming Maintains Long-Term Strain-Transcending Immunity against Blood-Stage Plasmodium chabaudi Malaria

November 5, 2013 - 12:55 -- NOT Open Access
Author(s): 
Henrique Borges da Silva, Érika Machado de Salles, Raquel Hoffmann Panatieri, Silvia Beatriz Boscardin, Sérgio Marcelo Rodríguez-Málaga, José Maria Álvarez, and Maria Regina D’Império Lima
Reference: 
The Journal of Immunology November 15, 2013 vol. 191 no. 10 5160-5169
MalariaWorld

The mechanism by which protective immunity to Plasmodium is lost in the absence of continued exposure to this parasite has yet to be fully elucidated.

Disrupting rhythms in Plasmodium chabaudi: costs accrue quickly and independently of how infections are initiated

October 31, 2013 - 07:02 -- Open Access
Author(s): 
O'Donnell AJ, Mideo N, Reece SE
Reference: 
Malaria Journal 2013, 12 :372 (26 October 2013)
MalariaWorld

It is beneficial for parasites to be in synchronization with their host's rhythm, regardless of the route of infection or the parasite stage inoculated.

NOT Open Access | Acute Plasmodium chabaudi Infection Dampens Humoral Responses to a Secondary T-Dependent Antigen but Enhances Responses to a Secondary T-Independent Antigen

October 22, 2013 - 07:35 -- NOT Open Access
Author(s): 
Joel R. Wilmore, Alexander C. Maue, Julie S. Lefebvre, Laura Haynes, and Rosemary Rochford
Reference: 
The Journal of Immunology November 1, 2013 vol. 191 no. 9 4731-4739
MalariaWorld

High rates of coinfection occur in malaria endemic regions, leading to more severe disease outcomes.

Quantifying variation in the potential for antibody-mediated apparent competition among nine genotypes of the rodent malaria parasite Plasmodium chabaudi

October 16, 2013 - 18:37 -- Open Access
Author(s): 
Karen J. Fairlie-Clarke, Judith E. Allen, Andrew F. Read, Andrea L. Graham
Reference: 
Infection, Genetics and Evolution, Volume 20, December 2013, Pages 270-275
MalariaWorld

Here, we quantify the potential for antibodies induced by one clone to bind another (i.e., to cause antibody-mediated apparent competition) for nine genetically distinct P. chabaudi clones.

Not Open Access | Acute Plasmodium chabaudi Infection Dampens Humoral Responses to a Secondary T-Dependent Antigen but Enhances Responses to a Secondary T-Independent Antigen

October 2, 2013 - 16:07 -- NOT Open Access
Author(s): 
Joel R. Wilmore, Alexander C. Maue, Julie S. Lefebvre, Laura Haynes, and Rosemary Rochford
Reference: 
The Journal of Immunology September 30, 2013 1301450
MalariaWorld

These data suggest that during P. chabaudi infection, there is a shift toward an extrafollicular Ab response that could be responsible for decreased Ab responses to secondary T-dependent Ags.

The Impact of Genetic Susceptibility to Systemic Lupus Erythematosus on Placental Malaria in Mice

May 22, 2013 - 06:59 -- Open Access
Author(s): 
Michael Waisberg, Christina K. Lin, Chiung-Yu Huang, Mirna Pena, Marlene Orandle, Silvia Bolland, Susan K. Pierce
Reference: 
PLoS ONE 8(5): e62820
MalariaWorld

Severe malaria, including cerebral malaria (CM) and placental malaria (PM), have been recognized to have many of the features of uncontrolled inflammation.

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