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plasmodium chabaudi

A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

July 15, 2019 - 15:12 -- Open Access
Sylvie M. Mimche, Choon-myung Lee, Edward T. Morgan, et al.
Malaria Journal 2019 18:234, 12 July 2019

Given the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizing enzymes. Previous studies have shown reduced clearance of quinine, a treatment for Plasmodium infection, in individuals with malaria.

Plasticity and genetic variation in traits underpinning asexual replication of the rodent malaria parasite, Plasmodium chabaudi

July 8, 2019 - 16:51 -- Open Access
Philip L. G. Birget, Kimberley F. Prior, Nicholas J. Savill, Lewis Steer and Sarah E. Reece
Malaria Journal 2019 18:222, 1 July 2019

The ability of malaria (Plasmodium) parasites to adjust investment into sexual transmission stages versus asexually replicating stages is well known, but plasticity in other traits underpinning the replication rate of asexual stages in the blood has received less attention. Such traits include burst size (the number of merozoites produced per schizont), the duration of the asexual cycle, and invasion preference for different ages of red blood cell (RBC).

Malaria infection promotes a selective expression of kinin receptors in murine liver

July 1, 2019 - 15:39 -- Open Access
Priscilla D. S. Ventura, Carolina P. F. Carvalho, Marcos L. Gazarini, et al.
Malaria Journal 2019 18:213, 24 June 2019

Malaria represents a worldwide medical emergency affecting mainly poor areas. Plasmodium parasites during blood stages can release kinins to the extracellular space after internalization of host kininogen inside erythrocytes and these released peptides could represent an important mechanism in liver pathophysiology by activation of calcium signaling pathway in endothelial cells of vertebrate host. Receptors (B1 and B2) activated by kinins peptides are important elements for the control of haemodynamics in liver and its physiology. The aim of this study was to identify changes in the liver host responses (i.e. kinin receptors expression and localization) and the effect of ACE inhibition during malaria infection using a murine model.

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria

September 5, 2017 - 16:29 -- Open Access
Érika Machado de Salles, Maria Nogueira de Menezes, Maria Regina D’Impe´rio-Lima, et al.
PLoS Pathog 13(8): e1006595

A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria.

Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi

June 21, 2017 - 15:37 -- Open Access
Lorena González-López, Rebeca Carballar-Lejarazú, Fidel de la Cruz Hernández-Hernández, et al.
PLoS ONE 12(6): e0176533

Ubiquitination tags proteins for different functions within the cell. One of the most abundant and studied ubiquitin modification is the Lys48 polyubiquitin chain that modifies proteins for their destruction by proteasome.

ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model

May 9, 2017 - 15:46 -- Open Access
Deirdre A. Cunningham, Jing-wen Lin, Jean Langhorne, et al.
Malaria Journal 2017 16:185, 3 May 2017

These results indicate that ICAM-1-mediated cytoadherence is important in the P. chabaudi model of malaria and suggest that for rodent malarias, as for P. falciparum, there may be multiple host and parasite molecules involved in sequestration.

Behavioural and neurological symptoms accompanied by cellular neuroinflammation in IL-10-deficient mice infected with Plasmodium chabaudi

August 26, 2016 - 17:48 -- Open Access
Kyle D. Wilson, Sonja J. Stutz, Lorenzo F. Ochoa, Gustavo A. Valbuena, Petra D. Cravens, Kelly T. Dineley, Gracie Vargas and Robin Stephens
Malaria Journal 2016 15:428, 24 August 2016

These studies demonstrate exacerbated neuroinflammation concurrent with development of behavioural symptoms in P. chabaudi infection of IL-10−/− animals.


NOT Open Access| Blood-stage malaria of Plasmodium chabaudi induces differential Tlr expression in the liver of susceptible and vaccination-protected Balb/c mice

May 3, 2016 - 15:23 -- NOT Open Access
Saleh Al-Quraishy, Mohamed A. Dkhil, Suliman Alomar, Abdel Azeem S. Abdel-Baki, Denis Delic, Frank Wunderlich & Marcos J. Araúzo-Bravo
Parasitology Research, May 2016, Volume 115, Issue 5, pp 1835-1843

Protective vaccination induces self-healing of otherwise lethal blood-stage infections of Plasmodium chabaudi malaria.

Quantifying Transmission Investment in Malaria Parasites

March 3, 2016 - 14:34 -- Open Access
Megan A. Greischar, Nicole Mideo, Andrew F. Read, Ottar N. Bjørnstad
PLoS Comput Biol 12(2): e1004718

Many microparasites infect new hosts with specialized life stages, requiring a subset of the parasite population to forgo proliferation and develop into transmission forms.

IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection

December 16, 2015 - 16:02 -- Open Access
Victor H. Carpio, Michael M. Opata, Marelle E. Montañez, Pinaki P. Banerjee, Alexander L. Dent, Robin Stephens
PLoS ONE 10(12): e0144654

CD4 T cells are required to fight malaria infection by promoting both phagocytic activity and B cell responses for parasite clearance.


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