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plasmodium chabaudi

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

June 3, 2020 - 15:54 -- Open Access
Subudhi AK, O'Donnell AJ, Pain A, et al.
Nat Commun. 2020 Jun 2; 11(1):2763

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown.

ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS

May 4, 2020 - 14:03 -- Open Access
Latham LE, Wikenheiser DJ, Stumhofer JS
PLoS Pathog 16(4): e1008527

The co-stimulatory molecule ICOS is associated with the induction and regulation of T helper cell responses, including the differentiation of follicular helper T (Tfh) cells and the formation and maintenance of memory T cells. However, the role of ICOS signaling in secondary immune responses is largely unexplored. Here we show that memory T cell formation and maintenance are influenced by persistent infection with P. chabaudi chabaudi AS infection, as memory T cell numbers decline in wild-type and Icos-/- mice after drug-clearance.

Moringa oleifera treatment increases Tbet expression in CD4+ T cells and remediates immune defects of malnutrition in Plasmodium chabaudi-infected mice

February 10, 2020 - 16:24 -- Open Access
Jennifer Pilotos, Kadra Abdu Ibrahim, Chishimba Nathan Mowa and Michael Makokha Opata
Malaria Journal 2020 19:62, 7 February 2020

Malaria is a worldwide problem that affects millions of people yearly. In rural areas where anti-malarial drugs are not easily accessible, many people use herbal treatments, such as Moringa oleifera, to treat a variety of diseases and ailments including malaria. While Moringa is reported to possess potent and curative anti-malarial properties, previous studies have mostly been restricted to assessment of parasitaemia. In this study, the effect of Moringa on malaria immunity in a murine model was investigated.

NOT Open Access | Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity

July 16, 2019 - 16:49 -- NOT Open Access
Edrous Alamer, Victor H. Carpio, Robin Stephens, et al.
Parasitology Research, July 2019, Volume 118, Issue 7, pp 2277–2285

Malaria-associated bacteremia accounts for up to one-third of deaths from severe malaria, and non-typhoidal Salmonella (NTS) has been reported as a major complication of severe malarial infection.

Medical Treatment: 

A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

July 15, 2019 - 15:12 -- Open Access
Sylvie M. Mimche, Choon-myung Lee, Edward T. Morgan, et al.
Malaria Journal 2019 18:234, 12 July 2019

Given the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizing enzymes. Previous studies have shown reduced clearance of quinine, a treatment for Plasmodium infection, in individuals with malaria.

Plasticity and genetic variation in traits underpinning asexual replication of the rodent malaria parasite, Plasmodium chabaudi

July 8, 2019 - 16:51 -- Open Access
Philip L. G. Birget, Kimberley F. Prior, Nicholas J. Savill, Lewis Steer and Sarah E. Reece
Malaria Journal 2019 18:222, 1 July 2019

The ability of malaria (Plasmodium) parasites to adjust investment into sexual transmission stages versus asexually replicating stages is well known, but plasticity in other traits underpinning the replication rate of asexual stages in the blood has received less attention. Such traits include burst size (the number of merozoites produced per schizont), the duration of the asexual cycle, and invasion preference for different ages of red blood cell (RBC).

Malaria infection promotes a selective expression of kinin receptors in murine liver

July 1, 2019 - 15:39 -- Open Access
Priscilla D. S. Ventura, Carolina P. F. Carvalho, Marcos L. Gazarini, et al.
Malaria Journal 2019 18:213, 24 June 2019

Malaria represents a worldwide medical emergency affecting mainly poor areas. Plasmodium parasites during blood stages can release kinins to the extracellular space after internalization of host kininogen inside erythrocytes and these released peptides could represent an important mechanism in liver pathophysiology by activation of calcium signaling pathway in endothelial cells of vertebrate host. Receptors (B1 and B2) activated by kinins peptides are important elements for the control of haemodynamics in liver and its physiology. The aim of this study was to identify changes in the liver host responses (i.e. kinin receptors expression and localization) and the effect of ACE inhibition during malaria infection using a murine model.

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria

September 5, 2017 - 16:29 -- Open Access
Érika Machado de Salles, Maria Nogueira de Menezes, Maria Regina D’Impe´rio-Lima, et al.
PLoS Pathog 13(8): e1006595

A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria.

Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi

June 21, 2017 - 15:37 -- Open Access
Lorena González-López, Rebeca Carballar-Lejarazú, Fidel de la Cruz Hernández-Hernández, et al.
PLoS ONE 12(6): e0176533

Ubiquitination tags proteins for different functions within the cell. One of the most abundant and studied ubiquitin modification is the Lys48 polyubiquitin chain that modifies proteins for their destruction by proteasome.

ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model

May 9, 2017 - 15:46 -- Open Access
Deirdre A. Cunningham, Jing-wen Lin, Jean Langhorne, et al.
Malaria Journal 2017 16:185, 3 May 2017

These results indicate that ICAM-1-mediated cytoadherence is important in the P. chabaudi model of malaria and suggest that for rodent malarias, as for P. falciparum, there may be multiple host and parasite molecules involved in sequestration.


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