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plasmodium chabaudi

Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model

June 29, 2021 - 13:53 -- Open Access
Author(s): 
Dacheux M, Chaouch S, Deregnaucourt C, et al.
Reference: 
Biochimie. 2021 Jun 24:S0300-9084(21)00155-3

We previously showed that injection of recombinant human group IIA secreted phospholipase A2 (hGIIA sPLA2) to Plasmodium chabaudi-infected mice lowers parasitaemia by 20%. Here, we show that transgenic (TG) mice overexpressing hGIIA sPLA2 have a peak of parasitaemia about 30% lower than WT littermates. During infection, levels of circulating sPLA2, enzymatic activity and plasma lipid peroxidation were maximal at day-14, the peak of parasitaemia.

NOT Open Access | CD49d marks Th1 and Tfh-like antigen-specific CD4 + T cells during Plasmodium chabaudi infection

May 5, 2021 - 08:40 -- NOT Open Access
Author(s): 
Jian JY, Inoue SI, Yui K, et al.
Reference: 
Int Immunol. 2021 Apr 29:dxab020

Upon activation, specific CD4 + T cells upregulate the expression of CD11a and CD49d, surrogate markers of pathogen-specific CD4 + T cells. However, using TCR transgenic mice specific for a Plasmodium antigen, termed PbT-II, we found that activated CD4 + T cells develop not only to CD11a hiCD49d hi cells, but also to CD11a hiCD49d lo cells during acute Plasmodium infection. CD49d hi PbT-II cells, localized in the red pulp of spleens, expressed transcription factor T-bet, and produced IFN-γ, indicating that they were Th1-type cells.

NOT Open Access | Plasmodium chabaudi Affects Mast Cell Degranulation as Measured by Carbon-Fiber Microelectrode Amperometry

April 20, 2021 - 15:37 -- NOT Open Access
Author(s): 
Xiong-Hang K, Haynes CL
Reference: 
ACS Infect Dis. 2021 Apr 15

Mast cells (MCs) are effector cells of the immune system commonly known for their role in asthma and allergy. They are present throughout biological systems in various tissues, serving as an interface between the biological system and environment. Previous work characterizing the impact of malaria on MCs revealed contradictory results, showing minimal to strong correlation between MC degranulation and disease progression.

Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

March 23, 2021 - 14:56 -- Open Access
Author(s): 
Nahrendorf W, Ivens A, Spence PJ
Reference: 
Elife. 2021 Mar 23;10:e63838

Immunity to malaria is often considered slow to develop but this only applies to defense mechanisms that function to eliminate parasites (resistance). In contrast, immunity to severe disease can be acquired quickly and without the need for improved pathogen control (tolerance). Using Plasmodium chabaudi, we show that a single malaria episode is sufficient to induce host adaptations that can minimise inflammation, prevent tissue damage and avert endothelium activation, a hallmark of severe disease.

Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen

January 14, 2021 - 08:45 -- Open Access
Author(s): 
Dos Santos LI, Torres TA, Diniz SQ, Gonçalves R, Caballero-Flores G, Núñez G, Gazzinelli RT, Maloy KJ, Ribeiro do V Antonelli L
Reference: 
Cell Rep. 2021 Jan 12;34(2):108613

Individuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr-) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr- bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality.

Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells

November 19, 2020 - 13:13 -- Open Access
Author(s): 
Araúzo-Bravo MJ, Delic D, Gerovska D, Wunderlich F
Reference: 
Vaccines (Basel). 2020 Nov 13;8(4):E677

The role of natural killer (NK) cells in the liver as first-line post infectionem (p.i.) effectors against blood-stage malaria and their responsiveness to protective vaccination is poorly understood. Here, we investigate the effect of vaccination on NK cell-associated genes induced in the liver by blood-stage malaria of Plasmodium chabaudi. Female Balb/c mice were vaccinated at weeks 3 and 1 before being infected with 106P. chabaudi-parasitized erythrocytes.

Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes

October 15, 2020 - 08:52 -- Open Access
Author(s): 
Kamiya T, Greischar MA, Schneider DS, Mideo N
Reference: 
PLoS Comput Biol. 2020 Oct 8;16(10):e1008211

To understand why some hosts get sicker than others from the same type of infection, it is essential to explain how key processes, such as host responses to infection and parasite growth, are influenced by various biotic and abiotic factors. In many disease systems, the initial infection dose impacts host morbidity and mortality. To explore drivers of dose-dependence and individual variation in infection outcomes, we devised a mathematical model of malaria infection that allowed host and parasite traits to be linear functions (reaction norms) of the initial dose.

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

August 9, 2020 - 16:31 -- Open Access
Author(s): 
Zhao Y, Hosking C, Cunningham D, Langhorne J, Lin JW
Reference: 
Sci Data. 2020 Aug 4;7(1):253

Malaria is a devastating infectious disease and the immune response is complex and dynamic during a course of a malarial infection. Rodent malaria models allow detailed time-series studies of the host response in multiple organs. Here, we describe two comprehensive datasets containing host transcriptomic data from both the blood and spleen throughout an acute blood stage infection of virulent or avirulent Plasmodium chabaudi infection in C57BL/6 mice.

T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria

July 28, 2020 - 15:07 -- Open Access
Author(s): 
Carpio VH, Aussenac F, Puebla-Clark L, Wilson KD, Villarino AV, Dent AL, Stephens R
Reference: 
iScience. 2020 Jul 24;23(7):101310

Hybrid Th1/Tfh cells (IFN-γ+IL-21+CXCR5+) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ+ T cells control parasitemia, whereas antibody and IL-21+Bcl6+ T cells effect final clearance, suggesting an evolutionary driver for the hybrid population. We found that CD4-intrinsic Bcl6, Blimp-1, and STAT3 coordinately regulate expression of the Th1 master regulator T-bet, supporting plasticity of CD4 T cells.

The skeletal muscles of mice infected with Plasmodium berghei and Plasmodium chabaudi reveal a crosstalk between lipid mediators and gene expression

July 15, 2020 - 15:22 -- Open Access
Author(s): 
Mauro Toledo Marrelli, Zhiying Wang, Jian Huang and Marco Brotto
Reference: 
Malaria Journal 2020 19:254, 14 July 2020

Malaria is one of the most prevalent infectious disease in the world with 3.2 billion humans at risk. Malaria causes splenomegaly and damage in other organs including skeletal muscles. Skeletal muscles comprise nearly 50% of the human body and are largely responsible for the regulation and modulation of overall metabolism. It is essential to understand how malaria damages muscles in order to develop effective preventive measures and/or treatments. Using a pre-clinical animal model, the potential molecular mechanisms of Plasmodium infection affecting skeletal muscles of mice were investigated.

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