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plasmodium chabaudi

Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes

October 15, 2020 - 08:52 -- Open Access
Kamiya T, Greischar MA, Schneider DS, Mideo N
PLoS Comput Biol. 2020 Oct 8;16(10):e1008211

To understand why some hosts get sicker than others from the same type of infection, it is essential to explain how key processes, such as host responses to infection and parasite growth, are influenced by various biotic and abiotic factors. In many disease systems, the initial infection dose impacts host morbidity and mortality. To explore drivers of dose-dependence and individual variation in infection outcomes, we devised a mathematical model of malaria infection that allowed host and parasite traits to be linear functions (reaction norms) of the initial dose.

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

August 9, 2020 - 16:31 -- Open Access
Zhao Y, Hosking C, Cunningham D, Langhorne J, Lin JW
Sci Data. 2020 Aug 4;7(1):253

Malaria is a devastating infectious disease and the immune response is complex and dynamic during a course of a malarial infection. Rodent malaria models allow detailed time-series studies of the host response in multiple organs. Here, we describe two comprehensive datasets containing host transcriptomic data from both the blood and spleen throughout an acute blood stage infection of virulent or avirulent Plasmodium chabaudi infection in C57BL/6 mice.

T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria

July 28, 2020 - 15:07 -- Open Access
Carpio VH, Aussenac F, Puebla-Clark L, Wilson KD, Villarino AV, Dent AL, Stephens R
iScience. 2020 Jul 24;23(7):101310

Hybrid Th1/Tfh cells (IFN-γ+IL-21+CXCR5+) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ+ T cells control parasitemia, whereas antibody and IL-21+Bcl6+ T cells effect final clearance, suggesting an evolutionary driver for the hybrid population. We found that CD4-intrinsic Bcl6, Blimp-1, and STAT3 coordinately regulate expression of the Th1 master regulator T-bet, supporting plasticity of CD4 T cells.

The skeletal muscles of mice infected with Plasmodium berghei and Plasmodium chabaudi reveal a crosstalk between lipid mediators and gene expression

July 15, 2020 - 15:22 -- Open Access
Mauro Toledo Marrelli, Zhiying Wang, Jian Huang and Marco Brotto
Malaria Journal 2020 19:254, 14 July 2020

Malaria is one of the most prevalent infectious disease in the world with 3.2 billion humans at risk. Malaria causes splenomegaly and damage in other organs including skeletal muscles. Skeletal muscles comprise nearly 50% of the human body and are largely responsible for the regulation and modulation of overall metabolism. It is essential to understand how malaria damages muscles in order to develop effective preventive measures and/or treatments. Using a pre-clinical animal model, the potential molecular mechanisms of Plasmodium infection affecting skeletal muscles of mice were investigated.

NOT Open Access | Biosynthesized silver nanoparticles regulate the iron status in the spleen of Plasmodium chabaudi-infected mice

July 14, 2020 - 09:49 -- NOT Open Access
Murshed M, Dkhil MA, Al-Shaebi EM, Qasem MAA, Mares MM, Aljawdah HMA, Alojayri G, Abdel-Gaber R, Al-Quraishy S
Environ Sci Pollut Res Int. 2020 Jul 11.

Malaria is a dangerous disease affecting millions around the globe. Biosynthesized nanoparticles are used against a variety of diseases including malaria worldwide. Here, silver nanoparticles (AgNPs) synthesized from the leaf extracts of Indigofera oblongifolia have been used in the treatment of mice infected with Plasmodium chabaudi to evaluate the expression of iron regulatory genes in the spleen.

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

June 3, 2020 - 15:54 -- Open Access
Subudhi AK, O'Donnell AJ, Pain A, et al.
Nat Commun. 2020 Jun 2; 11(1):2763

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown.

ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS

May 4, 2020 - 14:03 -- Open Access
Latham LE, Wikenheiser DJ, Stumhofer JS
PLoS Pathog 16(4): e1008527

The co-stimulatory molecule ICOS is associated with the induction and regulation of T helper cell responses, including the differentiation of follicular helper T (Tfh) cells and the formation and maintenance of memory T cells. However, the role of ICOS signaling in secondary immune responses is largely unexplored. Here we show that memory T cell formation and maintenance are influenced by persistent infection with P. chabaudi chabaudi AS infection, as memory T cell numbers decline in wild-type and Icos-/- mice after drug-clearance.

Moringa oleifera treatment increases Tbet expression in CD4+ T cells and remediates immune defects of malnutrition in Plasmodium chabaudi-infected mice

February 10, 2020 - 16:24 -- Open Access
Jennifer Pilotos, Kadra Abdu Ibrahim, Chishimba Nathan Mowa and Michael Makokha Opata
Malaria Journal 2020 19:62, 7 February 2020

Malaria is a worldwide problem that affects millions of people yearly. In rural areas where anti-malarial drugs are not easily accessible, many people use herbal treatments, such as Moringa oleifera, to treat a variety of diseases and ailments including malaria. While Moringa is reported to possess potent and curative anti-malarial properties, previous studies have mostly been restricted to assessment of parasitaemia. In this study, the effect of Moringa on malaria immunity in a murine model was investigated.

NOT Open Access | Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity

July 16, 2019 - 16:49 -- NOT Open Access
Edrous Alamer, Victor H. Carpio, Robin Stephens, et al.
Parasitology Research, July 2019, Volume 118, Issue 7, pp 2277–2285

Malaria-associated bacteremia accounts for up to one-third of deaths from severe malaria, and non-typhoidal Salmonella (NTS) has been reported as a major complication of severe malarial infection.

Medical Treatment: 

A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

July 15, 2019 - 15:12 -- Open Access
Sylvie M. Mimche, Choon-myung Lee, Edward T. Morgan, et al.
Malaria Journal 2019 18:234, 12 July 2019

Given the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizing enzymes. Previous studies have shown reduced clearance of quinine, a treatment for Plasmodium infection, in individuals with malaria.


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