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Rapid and quantitative antimalarial drug efficacy testing via the magneto-optical detection of hemozoin

August 24, 2020 - 15:07 -- Open Access
Molnár P, Orbán Á, Izrael R, Babai R, Marton L, Butykai Á, Karl S, Vértessy BG, Kézsmárki I
Sci Rep. 2020 Aug 20;10(1):14025

Emergence of resistant Plasmodium species makes drug efficacy testing a crucial part of malaria control. Here we describe a novel assay for sensitive, fast and simple drug screening via the magneto-optical detection of hemozoin, a natural biomarker formed during the hemoglobin metabolism of Plasmodium species. By quantifying hemozoin production over the intraerythrocytic cycle, we reveal that hemozoin formation is already initiated by ~ 6-12 h old ring-stage parasites.

Digging for care-seeking behaviour among gold miners in the Guyana hinterland: a qualitative doer non-doer analysis of social and behavioural motivations for malaria testing and treatment

July 7, 2020 - 13:55 -- Open Access
Shirley D. Yan, Jennifer Orkis, Saifra Khan Sohail, Sean Wilson, TrishAnn Davis and J. Douglas Storey
Malaria Journal 2020 19:235, 6 July 2020

Although Guyana has made significant progress toward malaria control, limited access to malaria testing and treatment services threatens those gains. Mining activities create breeding environments for mosquitoes, and the migrant and mobile mining populations are hard to reach with information and services. The Ministry of Public Health (MoPH) has trained volunteers to test and treat malaria cases in remote regions. However, it remains unclear how miners perceive these testers, the services they provide, or what their malaria care-seeking behaviour is in general. To better address these challenges, Breakthrough ACTION Guyana and MoPH conducted qualitative research from October to November 2018 in Regions 7 and 8 in Guyana.

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