A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters macrophage cytokine profiles, leads to higher arginase level and activity, and decreased nitric oxide synthase activity. This leads to more productive intracellular bacterial infections but is protective against malarial toxin hemozoin. Proteomics of macrophages reveal decreased liver X receptor (LXR) activation, inflammation and antibacterial defense in P47S macrophages.
To test that hypothesis, two subcolonies of both An. gambiae and An. coluzzii were established that were fixed for alternative 2La arrangements (2La or 2L+a) on an otherwise homosequential and shared genetic background.
You are invited to join us for an informal dialogue on African Malaria at the Pardee Center of Boston University, 67 Bay State Road near the Kenmore Square Station of the MBTA, We will begin with coffee and tea at 9:30 am. continuing until 11:30 when a simple box lunch will be provided.
Our host this time is Prof. Jim McCann of the African History Dept of BU. Jim has recently returned from Ethiopia where he and colleagues have been conducting field research on agriculture and malaria. Jim is also writing a book on malaria in Ethiopia which will soon be published.
This study assessed progress up to 2010 towards global malaria impact targets, in relation to Global Fund and other donor and domestic malaria programme financing over 2003 to 2009.
Although adjunctive therapy trials continue, the best hope for African children may lie in disease prevention. Strategies include bednets, chemoprophylaxis and vaccine development.
The larvae of An. gambiae s.s laboratory colony and An. gambiae s.l of wild populations were assayed and the larval mortality was observed at 12, 24 and 48 h after exposure period with the concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ppm.