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African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

February 3, 2020 - 16:33 -- Open Access
Kumar Sachin Singh, Julia I-Ju Leu, Farokh Dotiwala, et al.
Nat Commun. 2020; 11:473

A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters macrophage cytokine profiles, leads to higher arginase level and activity, and decreased nitric oxide synthase activity. This leads to more productive intracellular bacterial infections but is protective against malarial toxin hemozoin. Proteomics of macrophages reveal decreased liver X receptor (LXR) activation, inflammation and antibacterial defense in P47S macrophages.

Cuticular differences associated with aridity acclimation in African malaria vectors carrying alternative arrangements of inversion 2La

May 6, 2014 - 17:24 -- Open Access
Reidenbach KR, Cheng C, Liu F, Liu C, Besansky NJ, Syed Z
Parasites & Vectors 2014, 7 :176 (10 April 2014)

To test that hypothesis, two subcolonies of both An. gambiae and An. coluzzii were established that were fixed for alternative 2La arrangements (2La or 2L+a) on an otherwise homosequential and shared genetic background.

African Malaria Dialogue meets at Boston University on Friday morning 31 January 2014

January 26, 2014 - 00:35 -- William Jobin

You are invited to join us for an informal dialogue on African Malaria at the Pardee Center of Boston University, 67 Bay State Road near the Kenmore Square Station of the MBTA, We will begin with coffee and tea at 9:30 am. continuing until 11:30 when a simple box lunch will be provided.

Our host this time is Prof. Jim McCann of the African History Dept of BU. Jim has recently returned from Ethiopia where he and colleagues have been conducting field research on agriculture and malaria. Jim is also writing a book on malaria in Ethiopia which will soon be published.

Progress towards malaria control targets in relation to national malaria programme funding

January 15, 2013 - 15:08 -- Open Access
Korenromp EL, Hosseini M, Newman RD, Cibulskis RE
Malaria Journal 2013, 12:18 (14 January 2013)

This study assessed progress up to 2010 towards global malaria impact targets, in relation to Global Fund and other donor and domestic malaria programme financing over 2003 to 2009.

Pediatric cerebral malaria: a scourge of Africa

December 19, 2012 - 11:44 -- Open Access
Douglas G Postels, Yamikani F Chimalizeni, Macpherson Mallewa, Michael J Boivin & Karl B Seydel
Future Neurology, January 2013, Vol. 8, No. 1, Pages 67-85

Although adjunctive therapy trials continue, the best hope for African children may lie in disease prevention. Strategies include bednets, chemoprophylaxis and vaccine development.

Toxicity of essential oil from Indian borage on the larvae of the African malaria vector mosquito, Anopheles gambiae

December 5, 2012 - 13:56 -- Open Access
Kweka EJ, Senthilkumar A, Venkatesalu V
Parasites & Vectors 2012, 5:277 (3 December 2012)

The larvae of An. gambiae s.s laboratory colony and An. gambiae s.l of wild populations were assayed and the larval mortality was observed at 12, 24 and 48 h after exposure period with the concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 ppm.

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