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plasmdium falciparum

Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in Anopheles sinensis

April 26, 2016 - 16:21 -- Open Access
Chang X, Zhong D, Yan G, et al.
Parasites & Vectors 2016, 9 :228 (23 April 2016)

Despite the importance of kdr mutations in pyrethroid resistance, the evolutionary origin of the kdr mutations is unknown. This study aims to examine the evolutionary genetics of kdr mutations in relation to spatial population genetic structure of An. sinensis.

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals

March 17, 2015 - 14:10 -- Open Access
Susanne H. Hodgson, Katie J. Ewer, Adrian V. S. Hill, et al.
J Infect Dis. (2015) 211 (7): 1076-1086

We conducted an open-label, 2-site, partially randomized Plasmodium falciparum sporozoite controlled human malaria infection (CHMI) study to compare the clinical efficacy of ChAd63-MVA CS with ChAd63-MVA ME-TRAP.

NOT Open Access | Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiota

January 14, 2015 - 18:05 -- NOT Open Access
Guillaume Carissimo, Emilie Pondeville, Kenneth D. Vernick, et al.
Proceedings of the National Academy of Sciences of the USA vol. 112 no. 2

We compare them with the responses of the post-midgut systemic compartment, which is the site of the subsequent disseminated viral infection. Normal viral infection of the midgut requires bacterial flora and is inhibited by the activities of immune deficiency (Imd), JAK/STAT, and Leu-rich repeat immune factors.

Not Open Access | Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

November 5, 2014 - 17:16 -- NOT Open Access
Christopher J L Murray, Katrina F Ortblad, Theo Vos, et al.
The Lancet, Volume 384, Issue 9947, 13–19 September 2014, Pages 1005-1070

We analysed data for corrected case-notifications, expert opinions on the case-detection rate, prevalence surveys, and estimated cause-specific mortality using Bayesian meta-regression to generate consistent trends in all parameters.

Performance of community health workers managing malaria, pneumonia and diarrhoea under the community case management programme in central Uganda: a cross sectional study

September 25, 2014 - 11:46 -- Open Access
Bagonza J, Kibira SP, Rutebemberwa E
Malaria Journal 2014, 13 :367 (18 September 2014)

This study assessed factors influencing performance of CHWs managing malaria, pneumonia and diarrhoea under the Integrated Community Case Management (iCCM) programme in Wakiso district, central Uganda.

Preventive effect of permethrin-impregnated long-lasting insecticidal nets on the blood feeding of three major pyrethroid-resistant malaria vectors in western Kenya

August 22, 2014 - 17:27 -- Open Access
Kawada H, Ohashi K, Dida GO, Sonye G, Njenga SM, Mwandawiro C, Minakawa N
Parasites & Vectors 2014, 7 :383 (20 August 2014)

To investigate the behavioral pattern of mosquitoes in the houses where LLINs were used, indoor mosquito trappings of Anopheles gambiae s.s., An. arabiensis, and An. funestus s.s. were performed with Centers for Disease Control and Prevention (CDC) miniature light trap equipped with a collection bottle rotator at 2-hour intervals between 4:00 pm and 8:00 am.

Molecular characterization of the malaria vector Anopheles barbirostris van der Wulp in Sri Lanka

August 11, 2014 - 17:38 -- Open Access
Gajapathy K, Jude PJ, Goodacre SL, Peiris LB, Ramasamy R, Surendran SN
Parasites & Vectors 2014, 7 :348 (29 July 2014)

The present study characterizes Sri Lankan An. barbirostris using mtDNA cytochrome oxidase subunit I (COI) and ribosomal RNA internal transcribed spacer 2 (ITS2) gene sequences.

Not Open Access | The essential role of infection-detection technologies for malaria elimination and eradication

May 6, 2014 - 17:36 -- NOT Open Access
Kathleen Tietje, Kenneth Hawkins, Christine Clerk, Kelly Ebels, Sarah McGray, Chris Crudder, Lucy Okell, Paul LaBarre
Trends in Parasitology, Volume 30, Issue 5, May 2014, Pages 259-266

Here we review recent research on epidemiology and biology related to malaria elimination and operational factors that influence E&E strategies. We further propose use-scenarios and a target product profile framework to define and prioritize the required attributes of infection-detection technologies.

Cuticular differences associated with aridity acclimation in African malaria vectors carrying alternative arrangements of inversion 2La

May 6, 2014 - 17:24 -- Open Access
Reidenbach KR, Cheng C, Liu F, Liu C, Besansky NJ, Syed Z
Parasites & Vectors 2014, 7 :176 (10 April 2014)

To test that hypothesis, two subcolonies of both An. gambiae and An. coluzzii were established that were fixed for alternative 2La arrangements (2La or 2L+a) on an otherwise homosequential and shared genetic background.

A push-pull system to reduce house entry of malaria mosquitoes

April 9, 2014 - 19:24 -- Open Access
Menger DJ, Otieno B, de Rijk M, Mukabana W, van Loon JJ, Takken W
Malaria Journal 2014, 13 :119 (27 March 2014)

The outcome of this study suggests that a push-pull system based on attractive and repellent volatiles may successfully be employed to target mosquito vectors of human disease.


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