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plasmodium yoelii

UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies

January 26, 2016 - 19:25 -- Open Access
Author(s): 
Jian Li, Baowei Cai, Xin-zhuan Su, et al.
Reference: 
Malaria Journal 2016 15:30, 20 January 2016

The discoveries of UTR introns and differentially spliced introns between P. yoelii subspecies raise interesting questions on the potential role of these introns in regulating gene expression and evolution of malaria parasites.

NOT Open Access | Dendritic cells subsets mediated immune response during Plasmodium berghei ANKA and Plasmodium yoelii infection

May 19, 2015 - 06:15 -- NOT Open Access
Author(s): 
Tarun Keswani, Anirban Sengupta, Samrat Sarkar, Arindam Bhattacharyya
Reference: 
Cytokine, Volume 73, Issue 2, June 2015, Pages 198–206

The roles of dendritic cells (DCs) in mediating immunity against Plasmodium infection have been extensively investigated, but immune response during pathogenesis of malaria is still poorly understood.

Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA

May 4, 2015 - 10:35 -- Open Access
Author(s): 
Yanwei Qi, Feng Zhu, Xin-zhuan Su, et al.
Reference: 
mBio.00117-15, 10 March 2015 mBio vol. 6 no. 2 e00117-15

One unique feature of malaria parasites is the differential transcription of structurally distinct rRNA (rRNA) genes at different developmental stages:

Hybridization and pre-zygotic reproductive barriers in Plasmodium

April 11, 2015 - 11:40 -- Open Access
Author(s): 
Ramiro RS, Khan SM, Franke-Fayard B, Janse CJ, Obbard DJ, Reece SE
Reference: 
Proc Biol Sci. 2015 May 7;282(1806)

We use the rodent malaria parasites P. berghei and P. yoelii to investigate the ecology of mixed-species mating groups, identify proteins involved in pre-zygotic barriers, and examine their evolution.

NOT Open Access | CD47 regulates the phagocytic clearance and replication of the Plasmodium yoelii malaria parasite

March 11, 2015 - 16:16 -- NOT Open Access
Author(s): 
Rajdeep Banerjee, Sanjay Khandelwal, Yukiko Kozakai, Bikash Sahu, and Sanjai Kumar
Reference: 
PNAS March 10, 2015 vol. 112 no. 10 3062-3067

Several Plasmodium species exhibit a strong age-based preference for the red blood cells (RBC) they infect, which in turn is a major determinant of disease severity and pathogenesis.

NOT Open Access | Plasmodium Suppresses Expansion of T Cell Responses to Heterologous Infections

January 7, 2015 - 09:22 -- NOT Open Access
Author(s): 
Chelsi E. White, Nicolas F. Villarino, Sarah S. Sloan, Vitaly V. Ganusov, and Nathan W. Schmidt
Reference: 
The Journal of Immunology January 15, 2015 vol. 194 no. 2 697-708

Plasmodium remains a major pathogen causing malaria and impairing defense against other infections.

Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System

September 4, 2014 - 12:06 -- Open Access
Author(s): 
Cui Zhang, Bo Xiao, Jing Yuan, et al.
Reference: 
mBio.01414-14 1 July 2014 mBio vol. 5 no. 4 e01414-14

Malaria parasites are unicellular organisms residing inside the red blood cells, and current methods for editing the parasite genes have been inefficient.

Artesunate versus Chloroquine Infection–Treatment–Vaccination Defines Stage-Specific Immune Responses Associated with Prolonged Sterile Protection against Both Pre-erythrocytic and Erythrocytic Plasmodium yoelii Infection

July 22, 2014 - 09:40 -- Open Access
Author(s): 
Xiaohong Peng, Gladys J. Keitany, Marissa Vignali, Lin Chen, Claire Gibson, Kimberly Choi, Fusheng Huang, and Ruobing Wang
Reference: 
The Journal of Immunology August 1, 2014 vol. 193 no. 3 1268-1277

Sterile protection against malaria infection can be achieved through vaccination of mice and humans with whole Plasmodium spp. parasites.

NOT Open Access | Antimalarial efficacy, cytotoxicity, and genotoxicity of methanolic stem bark extract from Hintonia latiflora in a Plasmodium yoelii yoelii lethal murine malaria model

March 19, 2014 - 13:17 -- NOT Open Access
Author(s): 
Norma Rivera , Perla Y. López , Marcela Rojas , Teresa I. Fortoul , Diana Y. Reynada , Alberto J. Reyes , Ernesto Rivera , Hiram I. Beltrán & Filiberto Malagón
Reference: 
Parasitology Research, April 2014, Volume 113, Issue 4, pp 1529-1536

Traditional medicines have been used to treat malaria for thousands of years and are the source of artemisinin and quinine derivatives.

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

February 10, 2014 - 09:32 -- Open Access
Author(s): 
Jian Wu, Linjie Tian, Xin-zhuan Su, et al.
Reference: 
PNAS, January 28, 2014, vol. 111 no. 4

Malaria infection triggers vigorous host immune responses; however, the parasite ligands, host receptors, and the signaling pathways responsible for these reactions remain unknown or controversial.

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