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plasmodium yoelii

A novel Plasmodium yoelii pseudokinase, PypPK1, is involved in erythrocyte invasion and exflagellation center formation

January 27, 2020 - 13:22 -- Open Access
Ishizaki T, Chaiyawong N, Hakimi H, Asada M, Tachibana M, Ishino T, Yahata K, Kaneko O
Parasitology International, 14 January 2020, 102056

Malaria parasites proliferate by repeated invasion of and multiplication within erythrocytes in the vertebrate host. Sexually committed intraerythrocytic parasites undergo sexual stage differentiation to become gametocytes. After ingestion by the mosquito, male and female gametocytes egress from erythrocytes and fertilize within the mosquito midgut. A complex signaling pathway likely responds to environmental events to trigger gametogenesis and regulate fertilization; however, such knowledge remains limited for malaria parasites.

Plasmodium yoelii Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity

January 14, 2020 - 12:00 -- Open Access
Peng YC, Qi Y, Su XZ, et al.
mBio. 2020 Jan 7;11(1). pii: e02995-19

Erythrocyte-binding-like (EBL) proteins are known to play an important role in malaria parasite invasion of red blood cells (RBCs); however, any roles of EBL proteins in regulating host immune responses remain unknown. Here, we show that Plasmodium yoelii EBL (PyEBL) can shape disease severity by modulating the surface structure of infected RBCs (iRBCs) and host immune responses. We identified an amino acid substitution (a change of C to Y at position 741 [C741Y]) in the protein trafficking domain of PyEBL between isogenic P. yoellii nigeriensis strain N67 and N67C parasites that produce different disease phenotypes in C57BL/6 mice.

Validation of Plasmodium vivax centromere and promoter activities using Plasmodium yoelii

December 30, 2019 - 14:48 -- Open Access
Thawnashom K, Kaneko M, Xangsayarath P, Chaiyawong N, Yahata K, Asada M, Adams JH, Kaneko O
PLoS ONE 14(12): e0226884

Plasmodium vivax is the leading cause of malaria outside Africa and represents a significant health and economic burden on affected countries. A major obstacle for P. vivax eradication is the dormant hypnozoite liver stage that causes relapse infections and the limited antimalarial drugs that clear this stage. Advances in studying the hypnozoite and other unique biological aspects of this parasite are hampered by the lack of a continuous in vitro laboratory culture system and poor availability of molecular tools for genetic manipulation. In this study, we aim to develop molecular tools that can be used for genetic manipulation of P. vivax.

Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood

July 31, 2018 - 15:26 -- Open Access
Sean C. Murphy, Andrew S. Ishizuka, Robert A. Seder, et al.
Malaria Journal 2018 17:275, 27 July 2018

Beyond the first few hours after injection, sporozoite-derived Plasmodium 18S rRNA was not detected in peripheral blood.

Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes

February 10, 2018 - 15:51 -- Open Access
Taeko Moriyasu, Risa Nakamura, Sharmina Deloer, Masachika Senba, Masato Kubo, Megumi Inoue, Richard Culleton, Shinjiro Hamano
PLoS Negl Trop Dis 12(1): e0006197

Malaria and schistosomiasis are major parasitic diseases causing morbidity and mortality in the tropics.

Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development

January 3, 2018 - 14:42 -- Open Access
Cui Zhang, Zhenkui Li, Huiting Cui, Yuanyuan Jiang, Zhenke Yang, Xu Wang, Han Gao, Cong Liu, Shujia Zhang, Xin-zhuan Su and Jing Yuan
mBio vol. 8 no. 6, 12 December 2017 e01986-17

Malaria parasites have a complex life cycle with multiple developmental stages in mosquito and vertebrate hosts, and different developmental stages express unique sets of genes.

NOT Open Access | Correlation between in vitro and in vivo antimalarial activity of compounds using CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and CQ-resistant strain of P. yoelii

June 27, 2017 - 18:04 -- NOT Open Access
Kumkum Srivastava, Pooja Agarwal, Awakash Soni & S.K. Puri
Parasitology Research, July 2017, Volume 116, Issue 7, pp 1849–1854

Present efforts have been made to establish a correlation between in vitro and in vivo antimalarial activity using MIC, IC50 and IC90 values against CQ-sensitive (3D7) and CQ-resistant (K1) strains of Plasmodium falciparum and in vivo activity against Plasmodium yoelii.

Within-host selection of drug resistance in a mouse model of repeated interrupted treatment of Plasmodium yoelii infection

May 25, 2017 - 14:37 -- Open Access
Suci Nuralitha, Josephine E. Siregar, Din Syafruddin, Andy I. M. Hoepelman and Sangkot Marzuki
Malaria Journal 2017 16:216, 23 May 2017

RIT of P. yoelii infected mice led to rapid development of resistance to atovaquone and pyrimethamine.

NOT Open Access | Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality

December 22, 2016 - 12:31 -- NOT Open Access
Xiao Yu, Baowei Cai, Rong-Fu Wang, et al.
Immunity, Volume 45, Issue 5, 15 November 2016, Pages 1093–1107

Type I interferon (IFN) is critical for controlling pathogen infection; however, its regulatory mechanisms in plasmacytoid cells (pDCs) still remain unclear.

STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria

December 21, 2016 - 16:40 -- Open Access
Emily Spaulding, David Fooksman, Jamie M. Moore, Alex Saidi, Catherine M. Feintuch, Boris Reizis, Laurent Chorro, Johanna Daily, Grégoire Lauvau
PLoS Pathog 12(10): e1005975

Malaria remains a global health burden causing significant morbidity, yet the mechanisms underlying disease outcomes and protection are poorly understood.


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