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artemisia annua

Potential Emergence of Plasmodium Resistance to Artemisinin Induced by the Use of Artemisia annua for Malaria and COVID-19 Prevention in Sub-African Region

November 27, 2021 - 13:09 -- Open Access
Author(s): 
Ataba E, Dorkenoo AM, Nguepou CT, Bakai T, Tchadjobo T, Kadzahlo KD, Yakpa K, Atcha-Oubou T
Reference: 
Acta Parasitol. 2021 Nov 19:1-6

Plasmodium resistance to antimalarial drugs is an obstacle to the elimination of malaria in endemic areas. This situation is particularly dramatic for Africa, which accounts for nearly 92% of malaria cases worldwide. Drug pressure has been identified as a key factor in the emergence of antimalarial drug resistance. Indeed, this pressure is favoured by several factors, including the use of counterfeit forms of antimalarials, inadequate prescription controls, poor adherence to treatment regimens, dosing errors, and the increasing use of other forms of unapproved antimalarials.

Aging affects artemisinin synthesis in Artemisia annua

June 1, 2021 - 12:54 -- Open Access
Author(s): 
Li J, Chu XH, Wang XY, Feng BM, Yu ZX
Reference: 
Sci Rep. 2021 May 28;11(1):11297

Artemisinin (ART) is the most effective component in malaria treatment, however, the extremely low content restricts its clinical application. Therefore, it is urgent to increase the yield of ART. ART gradually accumulates with aging, small RNA (sRNA) and transcriptome analysis were applied on the leaves of 2-week-old (2 w) and 3-month-old (3 m) A. annua respectively.

NOT Open Access | AaWRKY9 contributes to light- and jasmonate-mediated to regulate the biosynthesis of artemisinin in Artemisia annua

May 12, 2021 - 09:04 -- NOT Open Access
Author(s): 
Fu X, Peng B, Tang K, et al.
Reference: 
New Phytol. 2021 May 1

Artemisinin, isolated from Artemisia annua L., is recommended as the preferred drug to fight malaria. Previous research showed that JA mediated promotion of artemisinin accumulation was dependent on light. However, the mechanism underlying the interaction of light and JA in the regulation of artemisinin accumulation is still unknown. We identified a WRKY transcription factor, AaWRKY9, using transcriptome analysis.

JA and ABA activated AaGSW1-AaTCP15/AaORA transcriptional cascade promotes artemisinin biosynthesis in Artemisia annua

February 8, 2021 - 10:21 -- Open Access
Author(s): 
Ma YN, Xu DB, Tang KX, et al.
Reference: 
Plant Biotechnol J. 2021 Feb 4

Artemisinin, a sesquiterpene lactone widely used in malaria treatment was discovered in the medicinal plant Artemisia annua. The biosynthesis of artemisinin is efficiently regulated by jasmonate (JA) and abscisic acid (ABA) via regulatory factors. However, the mechanisms linking JA and ABA signaling with artemisinin biosynthesis through an associated regulatory network of downstream transcription factors (TFs) remain enigmatic.

NOT Open Access | Artemisia annua - Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications

January 26, 2021 - 15:19 -- NOT Open Access
Author(s): 
Ekiert H, Świątkowska J, Klin P, Rzepiela A, Szopa A
Reference: 
Planta Med. 2021 Jan 22

Artemisia annua (annual mugwort) is a species that has long been used in traditional Asian medicine, mainly Chinese and Hindu. The species is widespread and known as a medicinal plant not only in Asia but also in Europe, in both Americas, and Australia. The species has become a subject of particular interest due to the 2015 Nobel Prize awarded for detecting the sesquiterpene lactone artemisinin in it and proving its antimalarial activities. The raw materials obtained from this species are Artemisiae annuae folium and Artemisiae annuae herba.

Artemisia annua, a Traditional Plant Brought to Light

July 20, 2020 - 16:01 -- Open Access
Author(s): 
Septembre-Malaterre A, Lalarizo Rakoto M, Gasque P, et al.
Reference: 
Int J Mol Sci. 2020 Jul 15;21(14):E4986

Traditional remedies have been used for thousand years for the prevention and treatment of infectious diseases, particularly in developing countries. Of growing interest, the plant Artemisia annua, known for its malarial properties, has been studied for its numerous biological activities including metabolic, anti-tumor, anti-microbial and immunomodulatory properties.

Arbuscular Mycorrhizal Fungus Rhizophagus irregularis Influences Artemisia annua Plant Parameters and Artemisinin Content under Different Soil Types and Cultivation Methods

June 18, 2020 - 11:04 -- Open Access
Author(s): 
Domokos E, Bíró-Janka B, Bálint J, Molnár K, Fazakas C, Jakab-Farkas L, Domokos J, Albert C, Mara G, Balog A
Reference: 
Microorganisms. 2020 Jun 15; 8(6):E899

Artemisinin extracted from Artemisia annua has been used efficiently in malaria treatment since 2005. In this study, the variations in plant parameters (plant biomass, glandular trichome density, essential oil total chemical content, artemisinin production, and polyphenol oxidase (PPO) activity) were tested under different soil types (Luvisol, Gleysol, Anthrosol and sterile peat) and cultivation conditions (potted plants in semi-open field, and open field experiments) for plants inoculated with arbuscular mycorrhizal fungus (AMF) Rizophagus irregularis.

Dried Leaf Artemisia Annua Improves Bioavailability of Artemisinin via Cytochrome P450 Inhibition and Enhances Artemisinin Efficacy Downstream

February 17, 2020 - 12:34 -- Open Access
Author(s): 
Desrosiers MR, Mittelman A, Weathers PJ
Reference: 
Biomolecules. 2020 Feb 7;10(2). pii: E254

Artemisia annua L. and artemisinin, have been used for millennia to treat malaria. We used human liver microsomes (HLM) and rats to compare hepatic metabolism, tissue distribution, and inflammation attenuation by dried leaves of A. annua (DLA) and pure artemisinin. For HLM assays, extracts, teas, and phytochemicals from DLA were tested and IC50 values for CYP2B6 and CYP3A4 were measured.

NOT Open Access | Determination of dihydroartemisinic acid in Artemisia annua L. by gas chromatography with flame ionization detection

August 26, 2016 - 15:12 -- NOT Open Access
Author(s): 
Na Tian, Yuwei Tang, Dongming Tian, Zhonghua Liu, Shuoqian Liu
Reference: 
Biomedical Chromatography

Dihydroartemisinic acid (DHAA) is the direct precursor to artemisinin, an effective anti-malaria compound from Artemisia annua L. (A. annua), and it can be transformed to artemisinin without the catalysis of enzyme.

Not Open Access | Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria

January 24, 2014 - 18:25 -- NOT Open Access
Author(s): 
Pamela J. Weathers, Nikole J. Jordan, Praphapan Lasin, Melissa J. Towler
Reference: 
Journal of Ethnopharmacology, Volume 151, Issue 2, 3 February 2014, Pages 858-863

This study provides evidence showing how both artemisinin and flavonoids are affected by digestion and dietary components for an orally consumed plant delivered therapeutic and that artemisinin delivered via dried leaves would likely be more bioavailable if provided as a tablet instead of a capsule.

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