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artemisia annua

NOT Open Access | Determination of dihydroartemisinic acid in Artemisia annua L. by gas chromatography with flame ionization detection

August 26, 2016 - 15:12 -- NOT Open Access
Author(s): 
Na Tian, Yuwei Tang, Dongming Tian, Zhonghua Liu, Shuoqian Liu
Reference: 
Biomedical Chromatography

Dihydroartemisinic acid (DHAA) is the direct precursor to artemisinin, an effective anti-malaria compound from Artemisia annua L. (A. annua), and it can be transformed to artemisinin without the catalysis of enzyme.

Not Open Access | Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria

January 24, 2014 - 18:25 -- NOT Open Access
Author(s): 
Pamela J. Weathers, Nikole J. Jordan, Praphapan Lasin, Melissa J. Towler
Reference: 
Journal of Ethnopharmacology, Volume 151, Issue 2, 3 February 2014, Pages 858-863

This study provides evidence showing how both artemisinin and flavonoids are affected by digestion and dietary components for an orally consumed plant delivered therapeutic and that artemisinin delivered via dried leaves would likely be more bioavailable if provided as a tablet instead of a capsule.

Not Open Access | The complexity of medicinal plants: The traditional Artemisia annua formulation, current status and future perspectives

October 16, 2013 - 18:54 -- NOT Open Access
Author(s): 
Frank van der Kooy, Shaun Edward Sullivan
Reference: 
Journal of Ethnopharmacology, Volume 150, Issue 1, 28 October 2013, Pages 1-13
MalariaWorld

This review aims to highlight the complexities we face in the general study of medicinal plants at the hand of three levels of complexity. These levels consist of (a) the chemistry of the medicinal plant, (b) the influence of the preparation method on the chemistry of the final formulation and (c) the influence of metabolism on the chemistry of the formulation.

Rational engineering plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency

February 28, 2013 - 15:30 -- Open Access
Author(s): 
Jian-Xu Li, Xin Fang, Qin Zhao, Ju-Xin Ruan, Chang-Qing Yang, Ling-Jian Wang, David J Miller, Juan A Faraldos, Rudolf K Allemann, Xiao-Ya Chen and Peng Zhang
Reference: 
Biochem. J. (2013)
MalariaWorld

Here, we report a new sesquiterpene synthase from A. annua, α-bisabolol synthase (AaBOS), which has high sequence identity to amorpha-4,11-diene synthase (AaADS), a key enzyme in artemisinin biosynthesis.

Should Artemisia annua (wormwood) tea be used as a prophylactic in endemic countries?

December 18, 2012 - 14:56 -- Bart G.J. Knols

This expert blog was contributed by Dr. Merlin Willcox, Honorary Secretary of the Research Initiative on Traditional Antimalarial Methods (RITAM), in response to the outcome of a poll on MalariaWorld and recent contributions regarding the use of Artemisia tea as a remedy for malaria.

As a scientist and medical doctor, I am interested in herbal medicines for malaria. No one can deny that they have been the source of the two most important and effective families of antimalarial drugs. Furthermore many people still rely on various herbal remedies for treating uncomplicated malaria. Much of my own research has aimed to investigate these objectively and to find the most effective remedies.
 
Artemisia annua is a very interesting plant and is the source of the most powerful antimalarial drug ever discovered, artemisinin. There are a few clinical trials which even show that it can be used as an “emergency, first-aid” treatment for malaria in semi-immune adults. However there are no published clinical trials which prove effect on the prevention of malaria, and no published clinical trials which demonstrate effectiveness in young children...

Free Book for MalariaWorld Members!

November 27, 2012 - 21:45 -- Bart G.J. Knols

This week I was contacted by Dr. Dana Dalrymple with a very unusual offer. He wishes to provide all MalariaWorld subscribers free access to his book 'Artemisia annua, Artemisinin, ACTs & Malaria Control in Africa' published just seven months ago. This is truly remarkable and we highly appreciate this gesture!

In his email he said: "This will get it to the heart of the international malaria community and doubtless reach many who otherwise may not have heard of, or had access to, it." That is the spirit of truly open and global collaboration we aim to achieve with MalariaWorld. So a big 'Thank you' to Dr. Dalrymple! If you download it, why not send him a private message through the platform (available to subcribers) to let him know you appreciate his action...

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