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artemisia annua

Artemisia annua, a Traditional Plant Brought to Light

July 20, 2020 - 16:01 -- Open Access
Septembre-Malaterre A, Lalarizo Rakoto M, Gasque P, et al.
Int J Mol Sci. 2020 Jul 15;21(14):E4986

Traditional remedies have been used for thousand years for the prevention and treatment of infectious diseases, particularly in developing countries. Of growing interest, the plant Artemisia annua, known for its malarial properties, has been studied for its numerous biological activities including metabolic, anti-tumor, anti-microbial and immunomodulatory properties.

Arbuscular Mycorrhizal Fungus Rhizophagus irregularis Influences Artemisia annua Plant Parameters and Artemisinin Content under Different Soil Types and Cultivation Methods

June 18, 2020 - 11:04 -- Open Access
Domokos E, Bíró-Janka B, Bálint J, Molnár K, Fazakas C, Jakab-Farkas L, Domokos J, Albert C, Mara G, Balog A
Microorganisms. 2020 Jun 15; 8(6):E899

Artemisinin extracted from Artemisia annua has been used efficiently in malaria treatment since 2005. In this study, the variations in plant parameters (plant biomass, glandular trichome density, essential oil total chemical content, artemisinin production, and polyphenol oxidase (PPO) activity) were tested under different soil types (Luvisol, Gleysol, Anthrosol and sterile peat) and cultivation conditions (potted plants in semi-open field, and open field experiments) for plants inoculated with arbuscular mycorrhizal fungus (AMF) Rizophagus irregularis.

Dried Leaf Artemisia Annua Improves Bioavailability of Artemisinin via Cytochrome P450 Inhibition and Enhances Artemisinin Efficacy Downstream

February 17, 2020 - 12:34 -- Open Access
Desrosiers MR, Mittelman A, Weathers PJ
Biomolecules. 2020 Feb 7;10(2). pii: E254

Artemisia annua L. and artemisinin, have been used for millennia to treat malaria. We used human liver microsomes (HLM) and rats to compare hepatic metabolism, tissue distribution, and inflammation attenuation by dried leaves of A. annua (DLA) and pure artemisinin. For HLM assays, extracts, teas, and phytochemicals from DLA were tested and IC50 values for CYP2B6 and CYP3A4 were measured.

NOT Open Access | Determination of dihydroartemisinic acid in Artemisia annua L. by gas chromatography with flame ionization detection

August 26, 2016 - 15:12 -- NOT Open Access
Na Tian, Yuwei Tang, Dongming Tian, Zhonghua Liu, Shuoqian Liu
Biomedical Chromatography

Dihydroartemisinic acid (DHAA) is the direct precursor to artemisinin, an effective anti-malaria compound from Artemisia annua L. (A. annua), and it can be transformed to artemisinin without the catalysis of enzyme.

Not Open Access | Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria

January 24, 2014 - 18:25 -- NOT Open Access
Pamela J. Weathers, Nikole J. Jordan, Praphapan Lasin, Melissa J. Towler
Journal of Ethnopharmacology, Volume 151, Issue 2, 3 February 2014, Pages 858-863

This study provides evidence showing how both artemisinin and flavonoids are affected by digestion and dietary components for an orally consumed plant delivered therapeutic and that artemisinin delivered via dried leaves would likely be more bioavailable if provided as a tablet instead of a capsule.

Not Open Access | The complexity of medicinal plants: The traditional Artemisia annua formulation, current status and future perspectives

October 16, 2013 - 18:54 -- NOT Open Access
Frank van der Kooy, Shaun Edward Sullivan
Journal of Ethnopharmacology, Volume 150, Issue 1, 28 October 2013, Pages 1-13

This review aims to highlight the complexities we face in the general study of medicinal plants at the hand of three levels of complexity. These levels consist of (a) the chemistry of the medicinal plant, (b) the influence of the preparation method on the chemistry of the final formulation and (c) the influence of metabolism on the chemistry of the formulation.

Rational engineering plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency

February 28, 2013 - 15:30 -- Open Access
Jian-Xu Li, Xin Fang, Qin Zhao, Ju-Xin Ruan, Chang-Qing Yang, Ling-Jian Wang, David J Miller, Juan A Faraldos, Rudolf K Allemann, Xiao-Ya Chen and Peng Zhang
Biochem. J. (2013)

Here, we report a new sesquiterpene synthase from A. annua, α-bisabolol synthase (AaBOS), which has high sequence identity to amorpha-4,11-diene synthase (AaADS), a key enzyme in artemisinin biosynthesis.

Should Artemisia annua (wormwood) tea be used as a prophylactic in endemic countries?

December 18, 2012 - 14:56 -- Bart G.J. Knols

This expert blog was contributed by Dr. Merlin Willcox, Honorary Secretary of the Research Initiative on Traditional Antimalarial Methods (RITAM), in response to the outcome of a poll on MalariaWorld and recent contributions regarding the use of Artemisia tea as a remedy for malaria.

As a scientist and medical doctor, I am interested in herbal medicines for malaria. No one can deny that they have been the source of the two most important and effective families of antimalarial drugs. Furthermore many people still rely on various herbal remedies for treating uncomplicated malaria. Much of my own research has aimed to investigate these objectively and to find the most effective remedies.
Artemisia annua is a very interesting plant and is the source of the most powerful antimalarial drug ever discovered, artemisinin. There are a few clinical trials which even show that it can be used as an “emergency, first-aid” treatment for malaria in semi-immune adults. However there are no published clinical trials which prove effect on the prevention of malaria, and no published clinical trials which demonstrate effectiveness in young children...

Free Book for MalariaWorld Members!

November 27, 2012 - 21:45 -- Bart G.J. Knols

This week I was contacted by Dr. Dana Dalrymple with a very unusual offer. He wishes to provide all MalariaWorld subscribers free access to his book 'Artemisia annua, Artemisinin, ACTs & Malaria Control in Africa' published just seven months ago. This is truly remarkable and we highly appreciate this gesture!

In his email he said: "This will get it to the heart of the international malaria community and doubtless reach many who otherwise may not have heard of, or had access to, it." That is the spirit of truly open and global collaboration we aim to achieve with MalariaWorld. So a big 'Thank you' to Dr. Dalrymple! If you download it, why not send him a private message through the platform (available to subcribers) to let him know you appreciate his action...

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