malaria parasite

NOT Open Access | Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum

Tags:

Ozonide Antimalarials Alkylate Heme, malaria parasite, plasmodium falciparum

Author(s):

Giannangelo C, Anderson D, Wang X, Vennerstrom JL, Charman SA, Creek DJ

Reference:

ACS Infect. Dis. 2019, 5, 12, 2076-2086

The mechanism of action of ozonide antimalarials involves activation by intraparasitic iron and the formation of highly reactive carbon-centered radicals that alkylate malaria parasite proteins. Given free intraparasitic heme is generally thought to be the iron source responsible for ozonide activation and its likely close proximity to the activated drug, we investigated heme as a possible molecular target of the ozonides.

Not Open Access | Unusual dynamics of the divergent malaria parasite PfAct1 actin filament

Tags:

Unusual dynamics, malaria parasite, PfAct1 actin filament

Author(s):

Hailong Lu, Patricia M. Fagnant, and Kathleen M. Trybus

Reference:

PNAS October 8, 2019 116 (41) 20418-20427

Gliding motility and host cell invasion by the apicomplexan parasite Plasmodium falciparum (Pf), the causative agent of malaria, is powered by a macromolecular complex called the glideosome that lies between the parasite plasma membrane and the inner membrane complex.

Medical Condition:

Plasmodium falciparum (Pf)

NOT Open Access | The Molecular Basis of Erythrocyte Invasion by Malaria Parasites

Tags:

malaria parasite

Author(s):

Alan F. Cowman, Christopher J. Tonkin, Wai-Hong Tham, Manoj T. Duraisingh

Reference:

Cell Host & Microbe, Volume 22, Issue 2, 9 August 2017, Pages 232-245

Plasmodium species cause malaria by proliferating in human erythrocytes.

Medical Condition:

plasmodium species

Not Open Access: Nanoparticle-Based Histidine-Rich Protein-2 Assay for the Detection of the Malaria Parasite Plasmodium falciparum

Tags:

malaria parasite, plasmodium falciparum

Author(s):

Yagahira E. Castro-Sesquen, Chloe Kim, Robert H. Gilman, David J. Sullivan, and Peter C. Searson

Reference:

Am J Trop Med Hyg 15-0772

The assay uses magnetic beads conjugated with anti-HRP2 antibody for protein capture and concentration, and antibody-conjugated quantum dots for optical detection. Western blot analysis demonstrated that magnetic beads allow the concentration of HRP2 protein in urine by 20-fold.

Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite

Tags:

Plasmodium knowlesi, malaria parasite

Author(s):

Selasi Dankwa, Caeul Lim, Manoj T. Duraisingh, et al.

Reference:

Nature Communications 7

We show that two P. knowlesi invasion ligands, PkDBPβ and PkDBPγ, bind specifically to Neu5Gc-containing receptors. A human-adapted P. knowlesi line invades human RBCs independently of Neu5Gc, with duplication of the sialic acid-independent invasion ligand, PkDBPα and loss of PkDBPγ.

Not Open Access | Malaria Parasite Density Estimation using Actual and Assumed White Blood Cells Count in Children in Eastern Sudan

Tags:

malaria parasite, children

Author(s):

Jalal A. Bilal, Gasim I. Gasim, Amani H. Karsani, Leana M. Elbashir and Ishag Adam

Reference:

J Trop Pediatr (2016) 62 (2): 171-175.

This study was conducted to determine the malaria parasite density among children using actual white blood cell (WBC) and the assumed WBC counts (8.0 × 109/l).

Country:

Sudan

Landscape and dynamics of transcription initiation in the malaria parasite Plasmodium falciparum

Tags:

malaria parasite, plasmodium falciparum

Author(s):

Sophie Adjalley, Christophe Chabbert, Bernd Klaus, Vicent Pelechano, Lars Steinmetz

Reference:

Bio Rxiv

This detailed analysis of TSS usage enabled us to define architectural features of plasmodial promoters. We demonstrate that TSS selection and strength are constrained by local nucleotide composition.

Not Open Access | A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum

Tags:

malaria parasite, plasmodium falciparum

Author(s):

Rosa V. Marchetti, Adele M. Lehane, Sarah H. Shafik, Markus Winterberg, Rowena E. Martin & Kiaran Kirk

Reference:

Nature Communications 6, Article number: 6721

In this study, we show that the human malaria parasite Plasmodium falciparum expresses at its surface a member of the microbial formate–nitrite transporter family (PfFNT), which, when expressed in Xenopus laevis oocytes, transports both formate and lactate.

Active case surveillance, passive case surveillance and asymptomatic malaria parasite screening illustrate different age distribution, spatial clustering and seasonality in western Kenya

Tags:

malaria parasite, malaria

Author(s):

Guofa Zhou, Yaw A Afrane, Sameer Malla, Andrew K Githeko, Guiyun Yan

Reference:

Malaria Journal 2015, 14:41 (28 January 2015)

The results revealed a significant difference in the age distribution of clinical cases between passive and active case surveillance, and between clinical case rate and asymptomatic parasite rate.

Country:

Kenya

A comprehensive evaluation of rodent malaria parasite genomes and gene expression

Tags:

malaria parasite, plasmodium falciparum

Author(s):

Thomas D Otto, Ulrike Böhme, Chris J Janse, et al.

Reference:

BMC Biology 2014, 12:86 (30 October 2014)

We have produced RNA-seq data and utilised it to improve gene-model prediction and to provide quantitative, genome-wide, data on gene expression. Comparison of the RMP genomes with the genome of the human malaria parasite P. falciparum and RNA-seq mapping permitted gene annotation at base-pair resolution.

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