Rapid diagnostic tests (RDTs) are selected based on their performances. Here, we compared the diagnostic performance of different malaria RDTs.
rapid diagnostic tests (RDTs)
Greece has been malaria-free since 1974. In October 2011, following an outbreak of 36 locally acquired malaria (LAM) cases in Evrotas Municipality, a Pro-Active Case Detection (PACD) program for malaria was implemented among migrants from malaria-endemic countries, to support early diagnosis and treatment of cases. We evaluated the PACD program for the years 2012–2017 using indicators such as the number of locally acquired cases, the detection rate/sensitivity and the timeliness of diagnosis and treatment.
Symptomatic malaria is predominantly a disease of childhood in areas of higher transmission (i.e. much of sub-Saharan Africa). Most cases of severe malaria occur in children less than 5 years of age. In these regions both malaria and sepsis are major causes of childhood death, yet the clinical distinction between the two is difficult, particularly if there is no obvious focus of infection. Furthermore, severe malaria predisposes to bacterial infections, particularly with Salmonella sp, so a very sick child may have both.
Malaria remains the biggest threat to public health, especially among pregnant women and young children in sub-Saharan Africa. Prompt and accurate diagnosis is critical for effective case management and detection of drug resistance. Conventionally, microscopy and rapid diagnostic tests (RDTs) are the tools of choice for malaria diagnosis. RDTs are simple to use and have been extensively used in the diagnosis of malaria among travelers to malaria-endemic regions, routine case management, and surveillance studies.
Variations in geographic and seasonal malaria commodity needs should be considered in CHW kit distribution planning in Mozambique.
Ensuring adequate and timely supplies of RDTs and ACT to PPM sites is critical.
Falciparum malaria persists in hard-to-reach areas or demographic groups that are missed by conventional healthcare systems but could be reached by trained community members in a malaria post (MP).
Most outlets never stocked RDTs; therefore, testing prior to treatment was unlikely for customers seeking treatment in the private retail sector.
The study suggests that HRP2-based RDTs are the most appropriate point-of-care test currently available for use during pregnancy especially for symptomatic women, but will still miss some PCR-positive women.
These findings highlight the importance of increased community sensitization as part of mass treatment campaigns for improving campaign coverage and acceptance