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Technology

Persistence Pays: piggyBac Remobilization in Anopheles

October 13, 2011 - 11:52 -- Mark Benedict
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Dave O’brochta of the University of Maryland has long insisted that merely developing the capacity to perform germline transformation of mosquitoes is not enough to claim a full-blown forward-genetic manipulation system. However, once transposable elements and vectors were available for Aedes and Anopheles, the enthusiasm for developing fundamentally new information about germline transformation waned – at least for many who would use it. Not for all though.

 

Open Access | Perspective: Malaria in Africa Can Be Eliminated

October 10, 2011 - 07:43 -- Patrick Sampao
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Author(s): 
Carlos C. Campbell and Richard W. Steketee
Reference: 
Am J Trop Med Hyg 2011 85:584-585

MalariaWorldEvidence suggests that this is a feasible goal using currently available interventions, augmented with newer tools such as vaccines, which are in development.

Open Access | Field and Laboratory Evaluation of Bioefficacy of an Insect Growth Regulator (Dimilin) as a Larvicide against Mosquito and Housefly Larvae

September 27, 2011 - 07:17 -- Patrick Sampao
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Author(s): 
Shandala Msangi, Ester Lyatuu, and Eliningaya J. Kweka
Reference: 
Journal of Tropical Medicine, Volume 2011 (2011)

The inhibitory function of Dimilin (Diflubenzuron), mostly a chitin synthesis regulator, on the ecdysis of mosquitoes (Anopheles gambiae s.l., Culex quinquefasciatus) and housefly was evaluated in the field and in laboratory.

Why Open Access 2.0 Ultimately Leads to Better Science

September 20, 2011 - 09:15 -- Tom Olijhoek

Apart from all the other arguments in favour of open access there may be two less obvious reasons to support it. These reasons are that it may contribute to better science by counter-acting the publication bias in the current publication system, and by discouraging selective publishing on the part of the author.

Open Access | A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs

September 6, 2011 - 07:51 -- Kabogo Ndegwa
Author(s): 
James S. McCarthy, Silvana Sekuloski, Andrew J. Humberstone, et al.
Reference: 
PLoS ONE 6(8): e21914

This system offers a flexible and safe approach to testing the in vivo activity of novel antimalarials.

Open Access | Worldwide Genetic Variability of the Duffy Binding Protein: Insights into Plasmodium vivax Vaccine Development

August 9, 2011 - 09:14 -- Kabogo Ndegwa
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Author(s): 
Taís Nóbrega de Sousa, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito
Reference: 
PLoS ONE 6(8): e22944

The dependence of Plasmodium vivax on invasion mediated by Duffy binding protein (DBP) makes this protein a prime candidate for development of a vaccine.

Open Access | Investigating preferences for mosquito-control technologies in Mozambique with latent class analysis

July 26, 2011 - 06:40 -- Kabogo Ndegwa
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Author(s): 
Smith RA, Barclay VC, Findeis JL
Reference: 
Malaria Journal 2011, 10:200 (21 July 2011)

To become widely diffused, best practices suggest that end-users should be included in product development to ensure that preferred attributes or traits are considered.

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Outcome of Poster Session on Innovative Alternatives to DDT held alongside the 5. Meeting of the Stockholm Convention

May 10, 2011 - 08:46 -- Stefanie Keller

Biovision, in support of the implementation of the Global Alliance for Alternatives to DDT, has organised a series of posters to present alternatives to DDT. The posters on innovative products, methods and alternative strategies for malaria vector control have been displayed alongside the Fifth Meeting of the Conference of the Parties to the Stockholm Convention.

Open Access | A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: amodiaquine and sulphadoxine-pyrimethamine

May 5, 2011 - 08:04 -- Kabogo Ndegwa
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Author(s): 
Shrawan Kumar Mishra, Prabhat Singh, Srikanta Kumar Rath
Reference: 
Malaria Journal 2011, 10:109 (2 May 2011)

These observations clearly indicate AQ+SP combination therapy is hepatotoxic in experimental Swiss mice.

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