At the moment I'm waiting at Boston's International airport for a flight to Detroit to visit a friend, but in a couple of days I'll be back here to participate in a Malaria Eradication Course at Harvard's school of public health. I just browsed through the names and positions of the participants enrolled in the course and got a chill... Not many of us doing research will be there.
HELP TO MAKE OPEN ACCESS A WORLDWIDE STANDARD FOR PUBLISHING SCIENCE
A very important point to make about this campaign is that THE PETITION CAN BE SIGNED BY ANYONE over 13 years in age with an email address, and from all parts of the world. So by signing this petition YOU CAN MAKE A DIFFERENCE. The more signatures there are , the louder the message will be and the more chance there will be for rapid change.
If you are willing to sign the petition please go to the website access2research and follow the directives. Alternatively you can go direct to the WEthePEOPLE website.
Please sign and tell your colleagues, family, friends that they can sign too.
This work presents a critical view on some QSAR models, and shows that, due to lack of a rigorous selection of the descriptors entering the models, most of them are unable to accurately indicate the molecular cause of biological activity. Some reasons for the weakness of the published models are discussed.
The Global Health Group at the University of California, San Francisco (UCSF) published 11 country briefings for the Asia Pacific which, for the first time, provide a comprehensive yet succinct overview of the history and current malaria situations in these countries.
We found that PfGAP45 is phosphorylated in response to Phospholipase C (PLC) and calcium signaling. It is phosphorylated by P. falciparum kinases Protein Kinase B (PfPKB) and Calcium Dependent Protein Kinase 1 (PfCDPK1), which are calcium dependent enzymes, at S89, S103 and S149.
There is apparently considerable discussion about early biting shifts in mosquitoes like An. arabiensis. (Why this might be so I hope to describe below – but be warned in a recent submission a referee questioned the number of Charlwood references quoted – I had to reply well they are really the only ones I know, and no one reads them anymore so why not – a bit like insinuating an obscure word that no one has ever read before into a text! - so you might at least know what to expect if I write anymore of them. i.e.
"If you walk over a paddle of water barefoot, the malaria virus and bacteria will get in through the soles of your feet and spread to the rest of the body
I blogged recently that getting the facts out about genetic engineering of mosquitoes would not be enough to persuade those who are hard anti-GM activists that they can be safely developed. I also argued that becoming an activist allowed one to abandon the bothersome constraints of truth. AAAS appears to agree with me, but have they made the right call?
Another group has engineered an anopheline to have a degree of Plasmodium immunity. Some of us hope for a mosquito that is ready to take a trip to the field, but can this one go the distance? Is it advisable?
Multiple cytokines and chemokines were quantified in plasma by luminex, and antigen-specific cytokine production in whole blood was determined by intracellular cytokine staining and flow cytometry, at ages 5, 9, 12 and 24 months.
Background
