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placental malaria

The impact of gravidity, symptomatology and timing of infection on placental malaria

June 26, 2020 - 11:17 -- Open Access
Erin E. Tran, Morgan L. Cheeks, Stephanie L. Gaw, et al.
Malaria Journal 2020 19:227, 24 June 2020

Placental malaria is associated with increased risk of adverse perinatal outcomes. While primigravidity has been reported as a risk factor for placental malaria, little is known regarding the relationship between gravidity, symptomatology and timing of Plasmodium falciparum infection and the development of placental malaria.

VAR2CSA binding phenotype has ancient origin and arose before Plasmodium falciparum crossed to humans: implications in placental malaria vaccine design

November 19, 2019 - 14:43 -- Open Access
Stéphane Gangnard, Arnaud Chêne, Sébastien Dechavanne, Anand Srivastava, Marion Avril, Joseph D. Smith & Benoît Gamain
Scientific Reports volume 9, Article number: 16978 (2019)

We explored the possibility that conserved epitopes could exist between VAR2CSA from the chimpanzee parasite Plasmodium reichenowi and Plasmodium falciparum sequences. Making use of VAR2CSA recombinant proteins originating from both species, we showed that VAR2CSA from P. reichenowi (Pr-VAR2CSA) binds to the placental receptor CSA with high specificity and affinity.

Statistical prediction of immunity to placental malaria based on multi-assay antibody data for malarial antigens

October 3, 2017 - 17:25 -- Open Access
Chathura Siriwardhana, Rui Fang, Ali Salanti, Rose G. F. Leke, Naveen Bobbili, Diane Wallace Taylor and John J. Chen
Malaria Journal 2017 16:391, 29 September 2017

Not surprising, significant differences were observed between PM positive (PM+) and PM negative (PM−) groups for Ab levels to the majority of malaria antigens.

Impact of placental Plasmodium falciparum malaria infection on the Cameroonian maternal and neonate’s plasma levels of some cytokines known to regulate T cells differentiation and function

November 22, 2016 - 17:38 -- Open Access
Jean Claude Djontu, Stalone Siewe Siewe, Rosette Megnekou, et al.
Malaria Journal 2016 15:561, 21 November 2016

Placental malaria downregulates maternal plasma levels of IL-17E, IL-27 and IL-28A and neonates’ plasma levels of IL-17E and IL-28A cytokines, which could help for parasite clearance and increase child birth weight.

Antibody responses to the full-length VAR2CSA and its DBL domains in Cameroonian children and teenagers

November 9, 2016 - 17:16 -- Open Access
Barriere A. Y. Fodjo, Njika Atemnkeng, Anna Babakhanyan, et al.
Malaria Journal 2016 15:532, 4 November 2016

The study suggests that children, including teenage girls acquire Ab to VAR2CSA domains and FV2, but Ab levels are much lower than those needed to protect women from placental infections and repertoire of Ab responses to DBL domains is different from those in pregnant women. Interestingly, children with severe malaria did not have higher Ab levels to VAR2CSA compared to healthy children.

Parasite dynamics in the peripheral blood and the placenta during pregnancy-associated malaria infection

September 27, 2016 - 16:41 -- Open Access
Lauren M. Cohee, Linda Kalilani-Phiri, Patricia Mawindo, Sudhaunshu Joshi, Matthew Adams, Leo Kenefic, Christopher G. Jacob, Terrie E. Taylor and Miriam K. Laufer
Malaria Journal 2016 15:483, 21 September 2016

Placental malaria can occur at any time during pregnancy.

Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

September 21, 2016 - 17:17 -- Open Access
Arnaud Chêne, Sophie Houard, Nicola K. Viebig, et al.
Malaria Journal 2016 15:476, 17 September 2016

Placental malaria caused by Plasmodium falciparum infection constitutes a major health problem manifesting as severe disease and anaemia in the mother, impaired fetal development, low birth weight or spontaneous abortion.

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1

September 10, 2016 - 17:32 -- Open Access
Marina Ayres Pereira, Thomas Mandel Clausen, Ali Salanti, et al.
PLoS Pathog 12(8): e1005831

During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the placenta, causing health problems for both the mother and fetus.

The risk of malaria in Ghanaian infants born to women managed in pregnancy with intermittent screening and treatment for malaria or intermittent preventive treatment with sulfadoxine/pyrimethamine

February 2, 2016 - 19:00 -- Open Access
Timothy Awine, Mark M. Belko, Abraham R. Oduro, Sunny Oyakhirome, Harry Tagbor, Daniel Chandramohan, Paul Milligan, Matthew Cairns, Brian Greenwood and John E. Williams
Malaria Journal 2016 15:46, 28 January 2016

Infants born to women managed with ISTp-AL during pregnancy were not at greatly increased risk of malaria compared with infants born to women who had received IPTp-SP.


A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA

December 15, 2015 - 14:24 -- Open Access
Susan Thrane, Christoph M. Janitzek, Mette Ø. Agerbæk, Sisse B. Ditlev, Mafalda Resende, Morten A. Nielsen, Thor G. Theander, Ali Salanti, Adam F. Sander
PLoS ONE 10(11): e0143071

Placental malaria caused by Plasmodium falciparum is a major cause of mortality and severe morbidity.


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