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anopheles funestus

Not Open Access | A 6.5kb intergenic structural variation enhances P450-mediated resistance to pyrethroids in malaria vectors lowering bed net efficacy

September 29, 2020 - 13:15 -- NOT Open Access
Mugenzi LMJ, Menze BD, Wondji CS, et al.
Mol Ecol. 2020 Sep 24

Elucidating the complex evolutionary armory that mosquitoes deploy against insecticides is crucial to maintain the effectiveness of insecticide-based interventions. Here, we deciphered the role of a 6.5kb structural variation (SV) in driving cytochrome P450-mediated pyrethroid resistance in the malaria vector, Anopheles funestus. Whole-genome pooled sequencing detected an intergenic 6.5kb SV between duplicated CYP6P9a/b P450s in pyrethroid-resistant mosquitoes through a translocation event.

Influence of GST- and P450-based metabolic resistance to pyrethroids on blood feeding in the major African malaria vector Anopheles funestus

September 22, 2020 - 10:33 -- Open Access
Nouage L, Elanga-Ndille E, Binyang A, Tchouakui M, Atsatse T, Ndo C, Kekeunou S, Wondji CS
PLoS One. 2020 Sep 18;15(9):e0230984

Insecticide resistance genes are often associated with pleiotropic effects on various mosquito life-history traits. However, very little information is available on the impact of insecticide resistance on blood feeding process in mosquitoes. Here, using two recently detected DNA-based metabolic markers in the major malaria vector, An. funestus, we investigated how metabolic resistance genes could affect the blood meal intake.

Investigating the molecular basis of multiple insecticide resistance in a major malaria vector Anopheles funestus (sensu stricto) from Akaka-Remo, Ogun State, Nigeria

August 19, 2020 - 16:09 -- Open Access
Atoyebi SM, Tchigossou GM, Djouaka R, et al.
Parasit Vectors. 2020 Aug 18;13(1):423

Understanding the mechanisms used by Anopheles mosquitoes to survive insecticide exposure is key to manage existing insecticide resistance and develop more suitable insecticide-based malaria vector control interventions as well as other alternative integrated tools. To this regard, the molecular basis of permethrin, DDT and dieldrin resistance in Anopheles funestus (sensu stricto) at Akaka-Remo was investigated.

Pyrethroid and Carbamate Resistance in Anopheles funestus Giles along Lake Kariba in Southern Zambia

July 6, 2020 - 17:04 -- Open Access
Chanda J, Saili K, Sikaala CH, et al.
Am J Trop Med Hyg. 2020 Jul 2.

Whereas data on insecticide resistance and its underlying mechanisms exist for parts of Zambia, data remain limited in the southern part of the country. This study investigated the status of insecticide resistance, metabolic mechanisms, and parasite infection in Anopheles funestus along Lake Kariba in southern Zambia. Indoor-resting mosquitoes were collected from 20 randomly selected houses within clusters where a mass drug administration trial was conducted and raised to F1 progeny.

Anopheles arabiensis and Anopheles funestus biting patterns in Dielmo, an area of low level exposure to malaria vectors

June 30, 2020 - 14:20 -- Open Access
Souleymane Doucoure, Omar Thiaw, Amélé N. Wotodjo, Charles Bouganali, Nafisatou Diagne, Philippe Parola and Cheikh Sokhna
Malaria Journal 2020 19:230, 26 June 2020

In Dielmo, Senegal, the widespread use of long-lasting insecticidal nets has decreased both the incidence of malaria and the density of the Anopheles population. However, persistent low-level malaria transmission may hamper efforts to eliminate the disease. Therefore, continuous monitoring of the vector population is needed in order to improve knowledge of Anopheles biting behaviour and to readjust control interventions.

Aquatic habitats of the malaria vector Anopheles funestus in rural south-eastern Tanzania

June 26, 2020 - 11:00 -- Open Access
Ismail H. Nambunga, Halfan S. Ngowo, Fredros O. Okumu, et al.
Malaria Journal 2020 19:219, 23 June 2020

In rural south-eastern Tanzania, Anopheles funestus is a major malaria vector, and has been implicated in nearly 90% of all infective bites. Unfortunately, little is known about the natural ecological requirements and survival strategies of this mosquito species.

An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons

June 8, 2020 - 14:50 -- Open Access
Weedall GD, Riveron JM, Hearn J, Irving H, Kamdem C, Fouet C, White BJ, Wondji CS
PLoS Genet 16(6): e1008822

Insecticide resistance in malaria vectors threatens to reverse recent gains in malaria control. Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to improve control strategies and preventing malaria resurgence. A genome-wide survey of Anopheles funestus genetic diversity Africa-wide revealed evidences of a major division between southern Africa and elsewhere, associated with different population histories.

NOT Open Access | Loop-mediated isothermal amplification (LAMP) assays for Anopheles funestus group and Anopheles gambiae complex species

March 17, 2020 - 15:14 -- NOT Open Access
Kamber T, Koekemoer LL, Mathis A
Med Vet Entomol. 2020 Mar 10

Species of the genus Anopheles vary with regard to their vector capacity for Plasmodium spp., the causative agent of malaria, and their accurate identification is often required. Loop‐mediated isothermal amplification (LAMP) is a rapid, simple and low‐cost method for specific DNA amplification.

Genetic differentiation and population structure of Anopheles funestus from Uganda and the southern African countries of Malawi, Mozambique, Zambia and Zimbabwe

February 24, 2020 - 13:58 -- Open Access
Kaddumukasa MA, Wright J, Muleba M, Stevenson JC, Norris DE, Coetzee M
Parasit Vectors. 2020 Feb 18;13(1):87

Anopheles funestus (s.s.) is a primary vector of the malaria parasite Plasmodium falciparum in Africa, a human pathogen that causes almost half a million deaths each year. The population structure of An. funestus was examined in samples from Uganda and the southern African countries of Malawi, Mozambique, Zambia and Zimbabwe.

Implication of Anopheles funestus in malaria transmission in the city of Yaoundé, Cameroon

February 22, 2020 - 16:52 -- Open Access
Djamouko-Djonkam L, Nkahe DL, Kopya E, Talipouo A, Ngadjeu CS, Doumbe-Belisse P, Bamou R, Awono-Ambene P, Tchuinkam T, Wondji CS, Antonio-Nkondjio C
Parasite, Volume 27, 2020

The contribution of Anopheles funestus to malaria transmission in the urban environment is still not well documented. The present study assesses the implication of An. funestus in malaria transmission in two districts, Nsam and Mendong, in the city of Yaoundé. Adult mosquitoes were collected using Centers for Disease Control and Prevention miniature light traps (CDC-LT) and human landing catches from April 2017 to March 2018 and were identified morphologically to the species level. Those belonging to the Anopheles gambiae complex and to the Anopheles funestus group were further processed by PCR to identify members of each complex/group.


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