The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10588 malaria professionals are enjoying the free benefits of MalariaWorld today

plasmodium species

NOT Open Access | Multilevel modelling of the risk of malaria among children aged under five years in Nigeria

September 22, 2020 - 10:31 -- NOT Open Access
Author(s): 
Oguoma VM, Anyasodor AE, Adeleye AO, Eneanya OA, Mbanefo EC
Reference: 
Trans R Soc Trop Med Hyg. 2020 Sep 18:traa096

Malaria is still a major cause of morbidity and mortality among children aged <5 y (U5s). This study assessed individual, household and community risk factors for malaria in Nigerian U5s.

NOT Open Access | Ape Origins of Human Malaria

September 10, 2020 - 14:23 -- NOT Open Access
Author(s): 
Sharp PM, Plenderleith LJ, Hahn BH
Reference: 
Annu Rev Microbiol. 2020 Sep 8;74:39-63

African apes harbor at least twelve Plasmodium species, some of which have been a source of human infection. It is now well established that Plasmodium falciparum emerged following the transmission of a gorilla parasite, perhaps within the last 10,000 years, while Plasmodium vivax emerged earlier from a parasite lineage that infected humans and apes in Africa before the Duffy-negative mutation eliminated the parasite from humans there.

Molecular epidemiological surveillance of Africa and Asia imported malaria in Wuhan, Central China: comparison of diagnostic tools during 2011–2018

September 5, 2020 - 14:58 -- Open Access
Author(s): 
Yiting Xie, Kai Wu, Weijia Cheng, Tingting Jiang, Yi Yao, Mingxing Xu, Yan Yang, Huabing Tan and Jian Li
Reference: 
Malaria Journal 2020 19:321, 3 September 2020

Malaria remains a serious public health problem globally. As the elimination of indigenous malaria continues in China, imported malaria has gradually become a major health hazard. Well-timed and accurate diagnoses could support the timely implementation of therapeutic schedules, reveal the prevalence of imported malaria and avoid transmission of the disease.

Rapid and quantitative antimalarial drug efficacy testing via the magneto-optical detection of hemozoin

August 24, 2020 - 15:07 -- Open Access
Author(s): 
Molnár P, Orbán Á, Izrael R, Babai R, Marton L, Butykai Á, Karl S, Vértessy BG, Kézsmárki I
Reference: 
Sci Rep. 2020 Aug 20;10(1):14025

Emergence of resistant Plasmodium species makes drug efficacy testing a crucial part of malaria control. Here we describe a novel assay for sensitive, fast and simple drug screening via the magneto-optical detection of hemozoin, a natural biomarker formed during the hemoglobin metabolism of Plasmodium species. By quantifying hemozoin production over the intraerythrocytic cycle, we reveal that hemozoin formation is already initiated by ~ 6-12 h old ring-stage parasites.

NOT Open Access | Design, synthesis and biological evaluation of several aromatic substituted chalcones as antimalarial agents

August 10, 2020 - 16:00 -- NOT Open Access
Author(s): 
Gopinathan A, Moidu M, Mukundan M, Ellickal Narayanan S, Narayanan H, Adhikari N
Reference: 
Drug Dev Res. 2020 Aug 6. doi: 10.1002/ddr.21727

Malaria is a communicable disease which is caused by protozoan's mainly Plasmodium species (P. falciparum, P. ovale, P. vivax, P. malariae and P. knowlesi). The increasing resistance of Plasmodium to available malarial drugs poses a great responsibility for the researchers in the field of malaria. To overcome this problem of resistance, this study aimed to design and synthesize a new class of antimalarial agent with chalcone as the main moiety.

NOT Open Access | A novel metabarcoded 18S ribosomal DNA sequencing tool for the detection of Plasmodium species in malaria positive patients

August 3, 2020 - 15:46 -- NOT Open Access
Author(s): 
Wahab A, Shaukat A, Ali Q, Hussain M, Khan TA, Khan MAU, Rashid I, Saleem MA, Evans M, Sargison ND, Chaudhry U
Reference: 
Infection, Genetics and Evolution, Volume 82, August 2020, 104305

Various PCR based methods have been described for the diagnosis of malaria, but most depend on the use of Plasmodium species-specific probes and primers; hence only the tested species are identified and there is limited available data on the true circulating species diversity. Sensitive diagnostic tools and platforms for their use are needed to detect Plasmodium species in both clinical cases and asymptomatic infections that contribute to disease transmission.

Genome-wide microsatellite characteristics of five human Plasmodium species, focusing on Plasmodium malariae and P. ovale curtisi

May 19, 2020 - 14:47 -- Open Access
Author(s): 
Mathema VB, Nakeesathit S, White NJ, Dondorp AM, Imwong M
Reference: 
Parasite, Volume 27, 2020

Microsatellites can be utilized to explore genotypes, population structure, and other genomic features of eukaryotes. Systematic characterization of microsatellites has not been a focus for several species of Plasmodium, including P. malariae and P. ovale, as the majority of malaria elimination programs are focused on P. falciparum and to a lesser extent P. vivax. Here, five human malaria species (P. falciparum, P. vivax, P. malariae, P. ovale curtisi, and P. knowlesi) were investigated with the aim of conducting in-depth categorization of microsatellites for P. malariae and P. ovale curtisi.

NOT Open Access | A novel metabarcoded 18S ribosomal DNA sequencing tool for the detection of Plasmodium species in malaria positive patients

April 6, 2020 - 16:10 -- NOT Open Access
Author(s): 
Wahab A, Shaukat A, Chaudhry U, et al.
Reference: 
Infect Genet Evol. 2020 Apr 2:104305

Various PCR based methods have been described for the diagnosis of malaria, but most depend on the use of Plasmodium species-specific probes and primers; hence only the tested species are identified and there is limited available data on the true circulating species diversity. Sensitive diagnostic tools and platforms for their use are needed to detect Plasmodium species in both clinical cases and asymptomatic infections that contribute to disease transmission.

Plasmodium knowlesi Malaria in Sabah, Malaysia, 2015-2017: Ongoing Increase in Incidence Despite Near-elimination of the Human-only Plasmodium Species

January 20, 2020 - 16:11 -- Open Access
Author(s): 
Cooper DJ, Rajahram GS, Barber BE, et al.
Reference: 
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 361–367

Malaysia aims to eliminate malaria by 2020. However, while cases of Plasmodium falciparum and Plasmodium vivax have decreased substantially, the incidence of zoonotic malaria from Plasmodium knowlesi continues to increase, presenting a major challenge to regional malaria control efforts. Here we report incidence of all Plasmodium species in Sabah, including zoonotic P. knowlesi, during 2015–2017.

A panel of recombinant proteins from human-infective Plasmodium species for serological surveillance

January 20, 2020 - 16:05 -- Open Access
Author(s): 
Nicole Müller-Sienerth, Jarrod Shilts, Gavin J. Wright, et al.
Reference: 
Malaria Journal 2020 19:31, 17 January 2020

Malaria remains a global health problem and accurate surveillance of Plasmodium parasites that are responsible for this disease is required to guide the most effective distribution of control measures. Serological surveillance will be particularly important in areas of low or periodic transmission because patient antibody responses can provide a measure of historical exposure. While methods for detecting host antibody responses to Plasmodium falciparum and Plasmodium vivax are well established, development of serological assays for Plasmodium knowlesi, Plasmodium ovale and Plasmodium malariae have been inhibited by a lack of immunodiagnostic candidates due to the limited availability of genomic information.

Pages

Subscribe to RSS - plasmodium species