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plasmodium species

Plasmodium knowlesi Malaria in Sabah, Malaysia, 2015-2017: Ongoing Increase in Incidence Despite Near-elimination of the Human-only Plasmodium Species

January 20, 2020 - 16:11 -- Open Access
Author(s): 
Cooper DJ, Rajahram GS, Barber BE, et al.
Reference: 
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 361–367

Malaysia aims to eliminate malaria by 2020. However, while cases of Plasmodium falciparum and Plasmodium vivax have decreased substantially, the incidence of zoonotic malaria from Plasmodium knowlesi continues to increase, presenting a major challenge to regional malaria control efforts. Here we report incidence of all Plasmodium species in Sabah, including zoonotic P. knowlesi, during 2015–2017.

A panel of recombinant proteins from human-infective Plasmodium species for serological surveillance

January 20, 2020 - 16:05 -- Open Access
Author(s): 
Nicole Müller-Sienerth, Jarrod Shilts, Gavin J. Wright, et al.
Reference: 
Malaria Journal 2020 19:31, 17 January 2020

Malaria remains a global health problem and accurate surveillance of Plasmodium parasites that are responsible for this disease is required to guide the most effective distribution of control measures. Serological surveillance will be particularly important in areas of low or periodic transmission because patient antibody responses can provide a measure of historical exposure. While methods for detecting host antibody responses to Plasmodium falciparum and Plasmodium vivax are well established, development of serological assays for Plasmodium knowlesi, Plasmodium ovale and Plasmodium malariae have been inhibited by a lack of immunodiagnostic candidates due to the limited availability of genomic information.

Malaria.tools-comparative genomic and transcriptomic database for Plasmodium species

January 15, 2020 - 14:47 -- Open Access
Author(s): 
Tan QW, Mutwil M
Reference: 
Nucleic Acids Research, Volume 48, Issue D1, 08 January 2020, Pages D768–D775

Malaria is a tropical parasitic disease caused by the Plasmodium genus, which resulted in an estimated 219 million cases of malaria and 435 000 malaria-related deaths in 2017. Despite the availability of the Plasmodium falciparum genome since 2002, 74% of the genes remain uncharacterized. To remedy this paucity of functional information, we used transcriptomic data to build gene co-expression networks for two Plasmodium species (P. falciparum and P. berghei), and included genomic data of four other Plasmodium species, P. yoelii, P. knowlesi, P. vivax and P. cynomolgi, as well as two non-Plasmodium species from the Apicomplexa, Toxoplasma gondii and Theileria parva.

Probing the composition of Plasmodium species contained in malaria infections in the Eastern region of Ghana

December 10, 2019 - 20:07 -- Open Access
Author(s): 
Amoah LE, Donu D, Abuaku B, Ahorlu C, Arhinful D, Afari E, Malm K, Koram KA
Reference: 
BMC Public Health. 2019 Dec 2;19(1):1617

Asymptomatic falciparum and non-falciparum malaria infections are major challenges to malaria control interventions, as they remain a source of continual infection in the community. This becomes even more important as the debate moves towards elimination and eradication.

Avian malaria alters the dynamics of blood feeding in Culex pipiens mosquitoes

March 20, 2019 - 15:43 -- Open Access
Author(s): 
Stéphane Cornet, Antoine Nicot, Ana Rivero and Sylvain Gandon
Reference: 
Malaria Journal 2019 18:82, 15 March 2019

The potential adaptive nature of this manipulation of mosquito behaviour is discussed in the light of previous studies on other malaria models.

Frozen blood clots can be used for the diagnosis of distinct Plasmodium species in man and non-human primates from the Brazilian Atlantic Forest

September 25, 2018 - 15:16 -- Open Access
Author(s): 
Filipe Vieira Santos de Abreu, Larissa Rodrigues Gomes, Maria de Fátima Ferreira-da-Cruz, et al.
Reference: 
Malaria Journal 2018 17:338, 24 September 2018

Blood clots from human and non-human primates may be an important and low cost source of DNA for malaria surveillance in the Atlantic Forest.

Molecular identification of Plasmodium species in symptomatic children of Democratic Republic of Congo

September 25, 2018 - 15:13 -- Open Access
Author(s): 
Hugo Kavunga-Membo, Gillon Ilombe, Jean Jacques Muyembe, et al.
Reference: 
Malaria Journal 2018 17:334, 20 September 2018

Although this study showed clearly that the most prevalent species identified was P. falciparum, the findings demonstrate the existence of non-falciparum malaria, especially P. malariae and P. vivax among children aged ≤ 5 years living both Kinshasa and North Kivu Provinces in DRC.

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In situ loop-mediated isothermal amplification (LAMP) for identification of Plasmodium species in wide-range thin blood smears

June 26, 2018 - 16:02 -- Open Access
Author(s): 
Muneaki Hashimoto, Hirokazu Sakamoto, Yusuke Ido, Masato Tanaka, Shouki Yatsushiro, Kazuaki Kajimoto and Masatoshi Kataoka
Reference: 
Malaria Journal 2018 17:235, 19 June 2018

The present work shows that the potential of in situ LAMP for the identification of Plasmodium species at the single cell level on hydrophilic-treated COC palates, allowing highly sensitive and accurate malaria diagnosis.

Plasmodium species differentiation by non-expert on-line volunteers for remote malaria field diagnosis

January 31, 2018 - 16:01 -- Open Access
Author(s): 
Alejandra Ortiz-Ruiz, María Postigo, Sara Gil-Casanova, Daniel Cuadrado, José M. Bautista, José Miguel Rubio, Miguel Luengo-Oroz and María Linares
Reference: 
Malaria Journal 2018 17:54, 30 January 2018

On-line volunteers with short-training are able to differentiate malaria parasite species and parasite stages from digitalized thin smears based on simple visual cues (shape, size, texture and colour).

Systematic review of the role of angiopoietin-1 and angiopoietin-2 in Plasmodium species infections: biomarkers or therapeutic targets?

December 6, 2016 - 18:52 -- Open Access
Author(s): 
Gerdie M. de Jong, Jasper J. Slager, Annelies Verbon, Jaap J. van Hellemond and Perry J. J. van Genderen
Reference: 
Malaria Journal 2016 15:581, 1 December 2016

Both Ang-1 and Ang-2 levels correlate with and can distinguish between malaria disease severity states within the group of malaria-infected patients.

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