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Benin

Not Open Access | Phenotypic Insecticide Resistance in Anopheles gambiae (Diptera: Culicidae): Specific Characterization of Underlying Resistance Mechanisms Still Matters

October 13, 2020 - 12:56 -- NOT Open Access
Author(s): 
Medjigbodo AA, Djogbenou LS, Koumba AA, Djossou L, Badolo A, Adoha CJ, Ketoh GK, Mavoungou JF
Reference: 
J Med Entomol. 2020 Oct 12:tjaa195

An effective control of malaria vectors requires an extensive knowledge of mechanisms underlying the resistance-phenotypes developed by these vectors against insecticides. We investigated Anopheles gambiae mosquitoes from Benin and Togo for their intensity of insecticide resistance and we discussed the involvement of genotyped mechanisms in the resistance-phenotypes observed.

Minimal tillage and intermittent flooding farming systems show a potential reduction in the proliferation of Anopheles mosquito larvae in a rice field in Malanville, Northern Benin

September 15, 2020 - 10:36 -- Open Access
Author(s): 
Innocent Djègbè, Merdie Zinsou, Edia Flavien Dovonou, Geneviève Tchigossou, Murielle Soglo, Razack Adéoti, Brice Gbaguidi, Seun Atoyebi, Fabrice Chandre, Martin Akogbéto, Jo Lines and Rousseau Djouaka
Reference: 
Malaria Journal 2020 19:333, 14 September 2020

Irrigation systems have been identified as one of the factors promoting malaria disease around agricultural farms in sub-Saharan Africa. However, if improved water management strategy is adopted during rice cultivation, it may help to reduce malaria cases among human population living around rice fields. This study aimed to assess the impact of the different irrigation practices on malaria transmission, as well as to evaluate the water management system that will best mitigate malaria transmission in Malanville, Benin.

Sub-optimal Intermittent Preventive Treatment in pregnancy (IPTp) is associated with an increased risk of submicroscopic P. falciparum infection in pregnant women: a prospective cohort study in Benin

September 10, 2020 - 08:51 -- Open Access
Author(s): 
Hounkonnou CPA, Ndam NT, Fievet N, Accrombessi M, Yovo E, Mama A, Sossou D, Vianou B, Massougbodji A, Briand V, Cot M, Cottrell G
Reference: 
Clin Infect Dis. 2020 Sep 9:ciaa1355

Harmful maternal and neonatal health outcomes result from malaria in pregnancy, the prevention of which primarily relies on intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP). WHO recommends IPTp-SP in sub-Saharan Africa, but implementation is highly heterogeneous and often sub-optimal in terms of the number of doses and their timing. In this study, we assessed the impact of this heterogeneity on malaria in pregnancy, mainly with respect to submicroscopic Plasmodium falciparum infections.

Stability testing of dried Plasmodium falciparum positive quality control samples for malaria rapid diagnostic tests in Liberia and Benin

August 17, 2020 - 13:27 -- Open Access
Author(s): 
Saliou Ramani, Henry T. Kohar, Oliver Pratt, Yves Eric Denon, Christie M. Reed, Peter Thomas, Suzanne E. Powell and Michael Aidoo
Reference: 
Malaria Journal 2020 19:288, 12 August 2020

Malaria rapid diagnostic tests (RDTs) are largely responsible for the gains made in the proportion of malaria cases confirmed with a parasitological test. However, quality assurance programs to support their use remain a challenge. A dried tube specimen (DTS) method was developed that showed potential for use as a stable source of quality control (QC) sample for RDTs and for use in external quality assessments or proficiency testing (PT). DTS was further assessed with focus on sample stability under field settings in Benin and Liberia.

SEPSIS project: a protocol for studying biomarkers of neonatal sepsis and immune responses of infants in a malaria-endemic region

July 29, 2020 - 10:16 -- Open Access
Author(s): 
Fievet N, Ezinmegnon S, Tissieres P, et al.
Reference: 
BMJ Open. 2020 Jul 23;10(7):e036905

Neonatal sepsis outreaches all causes of neonatal mortality worldwide and remains a major societal burden in low and middle income countries. In addition to limited resources, endemic morbidities, such as malaria and prematurity, predispose neonates and infants to invasive infection by altering neonatal immune response to pathogens. Nevertheless, thoughtful epidemiological, diagnostic and immunological evaluation of neonatal sepsis and the impact of gestational malaria have never been performed.

Indoor spraying with chlorfenapyr (a pyrrole insecticide) provides residual control of pyrethroid-resistant malaria vectors in southern Benin

July 14, 2020 - 09:47 -- Open Access
Author(s): 
Corine Ngufor, Augustin Fongnikin, Neil Hobbs, Martial Gbegbo, Laurette Kiki, Abibath Odjo, Martin Akogbeto and Mark Rowland
Reference: 
Malaria Journal 2020 19:249, 13 July 2020

New classes of insecticides with novel modes of action, which can provide effective and prolonged control of insecticide-resistant malaria vector populations, are urgently needed for indoor residual spraying. Such insecticides can be included in a rotation plan to manage and prevent further development of resistance in mosquito vectors of malaria. Chlorfenapyr, a novel pyrrole insecticide with a unique mode of action, is being developed as a long-lasting IRS formulation.

A genotypical study in Benin comparing the carriage of P. falciparum infections before pregnancy and in the early pregnancy: story of a persistent infection

June 26, 2020 - 15:06 -- Open Access
Author(s): 
Jafari-Guemouri S, Courtois L, Mama A, Rouas B, Neto Braga G, Accrombessi M, Massougbodji A, Ding XC, Tuikue Ndam N, Fievet N, Briand V
Reference: 
Clin Infect Dis. 2020 Jun 22:ciaa841

Malaria infections in the first trimester of pregnancy are frequent and deleterious for both mother and child health. To investigate if these early infections are newly acquired or already present in the host, we assessed whether parasites detected before pregnancy and those detected in early pregnancy are the same infection.

NOT Open Access | Circulating cytokines associated with poor pregnancy outcomes in Beninese exposed to infection with Plasmodium falciparum

June 9, 2020 - 16:20 -- NOT Open Access
Author(s): 
Hountohotegbe T, Gbedande K, Agbota G, Ibitokou S, Massougbodji A, Deloron P, Fievet N, Luty AJF
Reference: 
Infect Immun. 2020 Jun 8:IAI.00042-20

Malaria during pregnancy is a major cause of maternal morbidity as well as fetal and neonatal mortality. Previous studies including our own suggested that placental and peripheral cytokines and chemokines levels measured at delivery can be used as biomarkers for pregnancy outcomes. However, the timing of malaria infection during pregnancy matters and these studies lack in addressing the effect of different cytokines in peripheral blood plasma samples taken at early- mid-pregnancy and at delivery. Here we aimed to investigate whether peripheral plasma cytokine levels were associated with pregnancy outcomes in a cohort of 400 Beninese pregnant women.

Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women

May 25, 2020 - 08:47 -- Open Access
Author(s): 
Valérie Briand, Gilles Cottrell, Nadine Fievet, et al.
Reference: 
Malaria Journal 2020 19:188, 24 May 2020

While sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for the detection of infections of low parasite density in pregnant women.

A preliminary analysis on the effect of copper on Anopheles coluzzii insecticide resistance in vegetable farms in Benin

April 15, 2020 - 14:23 -- Open Access
Author(s): 
Talom AD, Essoung MA, Gbankoto A, Tchigossou G, Akoton R, Sahabi BBA, Atoyebi SM, Fotso Kuate A, Verspoor RL, Tamò M, Tchuinkam T, Lehman GL, Lines J, Wondji CS, Djouaka R
Reference: 
Sci Rep. 2020 Apr 14;10(1):6392

The use of agrochemicals in vegetable production could influence the selection for insecticide resistance in malaria vectors. Unfortunately, there is a dearth of information on the potential contribution of agrochemicals to insecticide resistance in Anopheles mosquitoes breeding on vegetable farms in southern Benin.

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